Prevalence and Significance of Anti‐HBc IgM (Radioimmunoassay) in Acute and Chronic Hepatitis B and in Blood Donors

Anti‐HBc IgM was determined by a modified radioimmunoassay (RIA) in 35 patients with acute hepatitis B, 35 patients with chronic hepatitis B (7 with chronic persistent, and 28 with chronic active hepatitis), 157 HBsAg positive blood donors, and in 143 HBsAg negative but anti‐HBc positive donors. The results of the RIA test were compared with those obtained by an ELISA technique. In chronic hepatitis, anti‐HBc IgM was correlated with the occurrence of HBeAg, anti‐HBe, Dane particles in the serum, HBsAg, and HBcAg in liver tissue and with biochemical and histological degrees of hepatic inflammatory activity.

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