Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques

[1]  G. Nolan,et al.  A Comprehensive Atlas of Immunological Differences Between Humans, Mice, and Non-Human Primates , 2022, Frontiers in Immunology.

[2]  Chao Tang,et al.  Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates , 2022, Nature Medicine.

[3]  Jeffrey R. Millman,et al.  Generation of insulin-producing pancreatic β cells from multiple human stem cell lines , 2021, Nature Protocols.

[4]  H. Valantine,et al.  The SIRPα–CD47 immune checkpoint in NK cells , 2021, The Journal of experimental medicine.

[5]  S. Yamanaka Pluripotent Stem Cell-Based Cell Therapy-Promise and Challenges. , 2020, Cell stem cell.

[6]  F. Urano,et al.  Gene-edited human stem cell–derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice , 2020, Science Translational Medicine.

[7]  Jeffrey R. Millman,et al.  Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells , 2020, Nature Biotechnology.

[8]  C. Esmon,et al.  Evidence for the important role of inflammation in xenotransplantation , 2019, Journal of Inflammation.

[9]  Mark M. Davis,et al.  Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients , 2019, Nature Biotechnology.

[10]  É. Vivier,et al.  Endogenous glucocorticoids control host resistance to viral infection through the tissue-specific regulation of PD-1 expression on NK cells , 2018, Nature Immunology.

[11]  R. Blasczyk,et al.  HLA-G peptide preferences change in transformed cells: impact on the binding motif , 2018, Immunogenetics.

[12]  Stephen P. Ma,et al.  Advanced maturation of human cardiac tissue grown from pluripotent stem cells , 2018, Nature.

[13]  Felix Feyertag,et al.  Phylogenetic Distribution of CMP-Neu5Ac Hydroxylase (CMAH), the Enzyme Synthetizing the Proinflammatory Human Xenoantigen Neu5Gc , 2017, Genome biology and evolution.

[14]  M. Caligiuri,et al.  The Broad Spectrum of Human Natural Killer Cell Diversity. , 2017, Immunity.

[15]  D. Clegg,et al.  HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells , 2017, Nature Biotechnology.

[16]  Pang Wei Koh,et al.  Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types , 2016, Cell.

[17]  T. Kieffer Closing in on Mass Production of Mature Human Beta Cells. , 2016, Cell stem cell.

[18]  Matthew A. Bochenek,et al.  Long term Glycemic Control Using Polymer Encapsulated, Human Stem-Cell Derived β-cells in Immune Competent mice , 2016, Nature Medicine.

[19]  Taku Kambayashi,et al.  Atypical MHC class II-expressing antigen-presenting cells: can anything replace a dendritic cell? , 2014, Nature Reviews Immunology.

[20]  D. Melton,et al.  Generation of Functional Human Pancreatic β Cells In Vitro , 2014, Cell.

[21]  James D. Johnson,et al.  Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells , 2014, Nature Biotechnology.

[22]  Longmei Zhao,et al.  Heterelogous expression of mutated HLA-G decreases immunogenicity of human embryonic stem cells and their epidermal derivatives. , 2014, Stem cell research.

[23]  S. Pittaluga,et al.  Path to the clinic: assessment of iPSC-based cell therapies in vivo in a nonhuman primate model. , 2014, Cell reports.

[24]  Boris Gala-Lopez,et al.  Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site , 2013, Clinical & developmental immunology.

[25]  P. Gianello,et al.  Bioengineered Sites for Islet Cell Transplantation , 2013, Current Diabetes Reports.

[26]  Kumaraswamy Nanthakumar,et al.  Biowire: a New Platform for Maturation of Human Pluripotent Stem Cell Derived Cardiomyocytes Pubmed Central Canada , 2022 .

[27]  J. Billingsley,et al.  No monkey business: why studying NK cells in non-human primates pays off , 2012, Front. Immun..

[28]  J. Sprent,et al.  The role of interleukin-2 during homeostasis and activation of the immune system , 2012, Nature Reviews Immunology.

[29]  A. Varki Letter to the Glyco-Forum: Since there are PAMPs and DAMPs, there must be SAMPs? Glycan “self-associated molecular patterns” dampen innate immunity, but pathogens can mimic them , 2011 .

[30]  A. Rajab Islet Transplantation: Alternative Sites , 2010, Current diabetes reports.

[31]  D. Nixon,et al.  Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by coexpression of CD56, CD7, and CD4. , 2009, Blood.

[32]  E. Kroon,et al.  Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells , 2006, Nature Biotechnology.

[33]  J. Bell,et al.  HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C , 1998, Nature.

[34]  H. Ljunggren,et al.  Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy , 1986, Nature.

[35]  S. H. van der Burg,et al.  Alternative peptide repertoire of HLA-E reveals a binding motif that is strikingly similar to HLA-A2. , 2013, Molecular immunology.