FOR PREVENTING THE TRANSMISSION OF OR TREATING PATIENTS INFECTED WITH HERPESVIRUS 75 Inventors :

Chemical Abstracts, vol. 105, No. 17, Oct. 27, 1986, Colum bus, OH, abstract No. 148687, V. Siksnis et al., "Stabiliza tion of Enzymes by their Chemical Modification with Cyclic Aromatic Acid Anhydrides”, DOkl. Akad. Nauk. SSSR, vol. 288, No. 6, 1986 (1508–1512). Chemical Abstracts, vol. 103, No. 23, Dec. 9, 1985, Colum bus, OH, abstract No. 192648, R.J.M. Parker & R.S. Hodges, “Photoaffinity Probes Provide a General Method to Prepare Peptide Conjugates from Native Protein Fragments”, J. Prot. Chem., vol. 3, No. 5–6, 1984 (479–489). Ostresh, J.M., Husar, G.M., Blondelle, S.E., Dorner, B., Weber, P.A., and Houghten, R.A., “Libraries from libraries: Chemical Transformation of Combinatorial Libraries to Extend the Range and Repertoire of Chemical Diversity', Proc. Natl. Acad. Sci. USA, 91, 11138-11142 (1994). Abraham, R., Singh, N., Mukhopadhyay, A., Basu, S.K., Bal, V., and Rath, S., “Modulation of Immunogenicity and Antigenicity of Proteins by Maleylation to Target Scavenger Receptors on Macrophages”, J. Immunol., 154, 1-8 (1994). Lo, T.W.C., Westwood, M.E., McLellan, A.C., Selwood, T. and Thornalley, P.J., “Binding and Modification of Proteins by Methylglyoxal Under Physiological Conditions. A Kinetic and Mechanistic Study with NC-Acetylarginine, NC-Acetylcysteine, and NC-Acetyllysine, and Bovine Serum Albumin”, J. Biol. Chem., 269,32299-32305 (1994). Westwood, M.E., McLellan, A.C., and Thornalley, P.J., “Receptor-mediated Endocytic Uptake of Methylgly oxal-modified Serum Albumin. Competition with Advanced Glycation End Product-modified Serum Albumin at the Advanced Glycation End Product Receptor”, J. Biol. Chem., 269,32293–32298 (1994). McKenzie, H.A., “Whole casein: Isolation, Properties, and Zone Electrophoresis”, In: Milk Proteins Chemistry and Molecular Biology, vol. II., H.A. McKenzie (ed.), pp. 87-116. Academic Press, New York (1971). Jansen, R.W., Molema, G., Pauwels, R., Schols, D., DeClercq, E. and Meijer, D.K.F., “Potent In Vitro Anti-Hu man Immunodeficiency Virus-1 Activity of Modified Human Serum Albumins’, Molecular Pharmacology, 39, 818–823 (1991). Takami, M., Sone, T., Mizumoto, K., Kino, K., and Tsunoo, H., “Maleylated Human Serum Albumin Inhibits HIV-1 infection in Vitro”, Biochem. Biophys. Acta., 1180, 180-186 (1992). Muckerheide, A., Apple, R.J., Pesce, A.J. and Michael, J.G., “Cationization of Protein Antigens”, I. Alteration of Immu nogenic Properties, The Journal of Immunology, 138, 833–837 (1987). Suzuki, T., Burlingame, R.W., Cavalot, F., Andres, G., Kashiwazaki, S. and Tan, E.M., “Antibodies in Rabbits Immunized with Cationized IgG React with Histones H3 and H4, Arthritis and Rheumatism, 35, 1218–1226 (1992). Virology, Fields, B.N., ed., Second Edition, Chapter 64, “Herpesviridae: A Brief Introduction', Bernard Roizman, 1787–1793 (1990). Lundblad, R.L., Chemical Reagents for Protein Modifica tion, 2nd Edition, CRC Press, Chapter 10, “The Modifica tion of Lysine”, 129–171 (1991).