Mechanistic Implications of GSK and CREB Crosstalk in Ischemia Injury.

[1]  A. Kaur,et al.  Therapeutic implications of phosphorylation- and dephosphorylation-dependent factors of cAMP-response element-binding protein (CREB) in neurodegeneration , 2023, Pharmacological Reports.

[2]  A. Kaur,et al.  Understanding mechanistic aspect of the therapeutic role of herbal agents on neuroplasticity in cerebral ischemic-reperfusion injury. , 2023, Journal of ethnopharmacology.

[3]  Lalitkumar K. Vora,et al.  GSK-3β: An Exuberating Neuroinflammatory Mediator in Parkinson's Disease. , 2023, Biochemical pharmacology.

[4]  T. G. Singh,et al.  Vitamin D as therapeutic modulator in cerebrovascular diseases: a mechanistic perspectives , 2022, Critical reviews in food science and nutrition.

[5]  T. G. Singh,et al.  Pharmacological Postconditioning by Protocatechuic Acid Attenuates Brain Injury in Ischemia–Reperfusion (I/R) Mice Model: Implications of Nuclear Factor Erythroid-2-Related Factor Pathway , 2022, Neuroscience.

[6]  T. G. Singh,et al.  Therapeutic Implications of Sonic Hedgehog Pathway in Metabolic Disorders: Novel Target for Effective Treatment. , 2022, Pharmacological research.

[7]  T. G. Singh,et al.  Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling , 2021, International journal of molecular sciences.

[8]  T. G. Singh,et al.  Neuropeptides: Potential neuroprotective agents in ischemic injury. , 2021, Life sciences.

[9]  C. Zheng,et al.  Ecto-5'-nucleotidase (CD73) inhibits dorsal root ganglion neuronal apoptosis by promoting the Ado/cAMP/PKA/CREB pathway , 2021, Experimental and therapeutic medicine.

[10]  M. Steinfath,et al.  Effects of different ischemic preconditioning strategies on physiological and cellular mechanisms of intestinal ischemia/reperfusion injury: Implication from an isolated perfused rat small intestine model , 2021, PloS one.

[11]  Xiaoxiang Chen,et al.  Curcumin attenuates renal ischemia reperfusion injury via JNK pathway with the involvement of p300/CBP-mediated histone acetylation , 2021, The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.

[12]  H. Mahajan,et al.  Cerebral ischemic stroke and different approaches for treatment of stroke , 2021, Future Journal of Pharmaceutical Sciences.

[13]  P. Ditonno,et al.  Novel Insights into the Molecular Mechanisms of Ischemia/Reperfusion Injury in Kidney Transplantation , 2021, Transplantology.

[14]  Guibo Sun,et al.  Notoginsenoside R1 Improves Cerebral Ischemia/Reperfusion Injury by Promoting Neurogenesis via the BDNF/Akt/CREB Pathway , 2021, Frontiers in Pharmacology.

[15]  M. Rossi,et al.  Deciphering the Role of Heme Oxygenase-1 (HO-1) Expressing Macrophages in Renal Ischemia-Reperfusion Injury , 2021, Biomedicines.

[16]  T. Behl,et al.  Recognizing the Benefits of Pre-/Probiotics in Metabolic Syndrome and Type 2 Diabetes Mellitus Considering the Influence of Akkermansia muciniphila as a Key Gut Bacterium , 2021, Microorganisms.

[17]  T. G. Singh,et al.  CREB: A Multifaceted Target for Alzheimer's Disease. , 2021, Current Alzheimer research.

[18]  T. Behl,et al.  Multifaceted Role of Matrix Metalloproteinases in Neurodegenerative Diseases: Pathophysiological and Therapeutic Perspectives , 2021, International journal of molecular sciences.

[19]  Lai-Hua Xie,et al.  Cardiac adaptation and cardioprotection against arrhythmias and ischemia-reperfusion injury in mammalian hibernators , 2021, Pflügers Archiv - European Journal of Physiology.

[20]  T. G. Singh,et al.  Novel Targets Explored in Treatment of Alcohol Dependence induced Withdrawal Syndrome. , 2020, CNS & neurological disorders drug targets.

[21]  Rajwinder Kaur,et al.  Exploring the multifocal role of phytochemicals as immunomodulators. , 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[22]  J. Chen,et al.  Syringic acid mitigates myocardial ischemia reperfusion injury by activating the PI3K/Akt/GSK-3β signaling pathway. , 2020, Biochemical and biophysical research communications.

[23]  T. G. Singh,et al.  Pharmacological postconditioning: a molecular aspect in ischemic injury , 2020, The Journal of pharmacy and pharmacology.

[24]  T. G. Singh,et al.  Cyclic Nucleotides Signaling and Phosphodiesterase Inhibition: Defying Alzheimer's Disease. , 2020, Current drug targets.

[25]  W. Xu,et al.  Astaxanthin alleviates spinal cord ischemia-reperfusion injury via activation of PI3K/Akt/GSK-3β pathway in rats , 2020, Journal of Orthopaedic Surgery and Research.

[26]  G. Heusch Myocardial ischaemia–reperfusion injury and cardioprotection in perspective , 2020, Nature Reviews Cardiology.

[27]  G. Ghali,et al.  Nafamostat mesylate attenuates the pathophysiologic sequelae of neurovascular ischemia , 2020, Neural regeneration research.

[28]  Xia Li,et al.  Adiponectin peptide alleviates oxidative stress and NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK/GSK-3β , 2020, Experimental Neurology.

[29]  Shusen Zheng,et al.  PACAP neuropeptide promotes Hepatocellular Protection via CREB-KLF4 dependent autophagy in mouse liver Ischemia Reperfusion Injury , 2020, Theranostics.

[30]  Y. Leng,et al.  Ischemic Postconditioning Alleviates Intestinal Ischemia-Reperfusion Injury by Enhancing Autophagy and Suppressing Oxidative Stress through the Akt/GSK-3β/Nrf2 Pathway in Mice , 2020, Oxidative medicine and cellular longevity.

[31]  Ji Xiao,et al.  Glycogen synthase kinase-3 as a key regulator of cognitive function. , 2020, Acta biochimica et biophysica Sinica.

[32]  S. Bhatia,et al.  The signaling interplay of GSK-3β in myocardial disorders. , 2020, Drug discovery today.

[33]  D. Pellegrini-Giampietro,et al.  Tolerance Induced by (S)-3,5-Dihydroxyphenylglycine Postconditioning is Mediated by the PI3K/Akt/GSK3β Signalling Pathway in an In Vitro Model of Cerebral Ischemia , 2020, Neuroscience.

[34]  John H. Zhang,et al.  The Role of Oxidative Stress in Common Risk Factors and Mechanisms of Cardio-Cerebrovascular Ischemia and Depression , 2019, Oxidative medicine and cellular longevity.

[35]  P. Koh,et al.  Resveratrol modulates the Akt/GSK-3β signaling pathway in a middle cerebral artery occlusion animal model , 2019, Laboratory Animal Research.

[36]  P. Évora,et al.  Ischemia/Reperfusion Injury Revisited: An Overview of the Latest Pharmacological Strategies , 2019, International journal of molecular sciences.

[37]  Lianglong Chen,et al.  Adropin reduces hypoxia/reoxygenation-induced myocardial injury via the reperfusion injury salvage kinase pathway. , 2019, Experimental and therapeutic medicine.

[38]  Shuai Su,et al.  GSK-3β Inhibitor Induces Expression of the TLR4/MyD88/NF-κB Signaling Pathway to Protect Against Renal Ischemia-Reperfusion Injury During Rat Kidney Transplantation , 2019, Inflammation.

[39]  T. G. Singh,et al.  Effects of Resveratrol Postconditioning on Cerebral Ischemia in mice: Role of the Sirtuin-1 (SIRT1) Pathway. , 2019, Canadian journal of physiology and pharmacology.

[40]  T. G. Singh,et al.  Neuroprotective effect of pharmacological postconditioning on cerebral ischaemia–reperfusion‐induced injury in mice , 2019, The Journal of pharmacy and pharmacology.

[41]  Jianwen Hou,et al.  A Meta-Analysis of Resveratrol Protects against Myocardial Ischemia/Reperfusion Injury: Evidence from Small Animal Studies and Insight into Molecular Mechanisms , 2019, Oxidative medicine and cellular longevity.

[42]  N. M. Zakharova,et al.  A pharmacological composition for induction of a reversible torpor‐like state and hypothermia in rats , 2019, Life sciences.

[43]  Kuan-Lun Li,et al.  Fucoidan–Fucoxanthin Ameliorated Cardiac Function via IRS1/GRB2/ SOS1, GSK3β/CREB Pathways and Metabolic Pathways in Senescent Mice , 2019, Marine drugs.

[44]  M. Nicholson,et al.  Ischemia-reperfusion injury in renal transplantation: 3 key signaling pathways in tubular epithelial cells. , 2019, Kidney international.

[45]  W. Xue,et al.  Probiotics ameliorate renal ischemia-reperfusion injury by modulating the phenotype of macrophages through the IL-10/GSK-3β/PTEN signaling pathway , 2018, Pflügers Archiv - European Journal of Physiology.

[46]  C. Peixoto,et al.  Molecular Mechanisms of Phosphodiesterase-5 Inhibitors on Neuronal Apoptosis. , 2018, DNA and cell biology.

[47]  Xia Li,et al.  Adiponectin confers neuroprotection against cerebral ischemia-reperfusion injury through activating the cAMP/PKA-CREB-BDNF signaling , 2018, Brain Research Bulletin.

[48]  Qianming Du,et al.  Salidroside alleviates ischemic brain injury in mice with ischemic stroke through regulating BDNK mediated PI3K/Akt pathway , 2018, Biochemical pharmacology.

[49]  Giou-Teng Yiang,et al.  Current Mechanistic Concepts in Ischemia and Reperfusion Injury , 2018, Cellular Physiology and Biochemistry.

[50]  B. Elibol,et al.  Thymoquinone Can Improve Neuronal Survival and Promote Neurogenesis in Rat Hippocampal Neurons , 2018, Molecular nutrition & food research.

[51]  Kaixun Huang,et al.  Rifampicin Prevents SH-SY5Y Cells from Rotenone-Induced Apoptosis via the PI3K/Akt/GSK-3β/CREB Signaling Pathway , 2018, Neurochemical Research.

[52]  Jie Liang,et al.  Daidzein ameliorates spinal cord ischemia/reperfusion injury-induced neurological function deficits in Sprague-Dawley rats through PI3K/Akt signaling pathway , 2017, Experimental and therapeutic medicine.

[53]  T. Force,et al.  Entanglement of GSK-3β, β-catenin and TGF-β1 signaling network to regulate myocardial fibrosis. , 2017, Journal of molecular and cellular cardiology.

[54]  Stephen L. Abrams,et al.  Regulation of GSK-3 activity by curcumin, berberine and resveratrol: Potential effects on multiple diseases. , 2017, Advances in biological regulation.

[55]  H. Zhang,et al.  Activation of Endocannabinoid Receptor 2 as a Mechanism of Propofol Pretreatment-Induced Cardioprotection against Ischemia-Reperfusion Injury in Rats , 2017, Oxidative medicine and cellular longevity.

[56]  Su-en Ren,et al.  Impact of propofol on renal ischemia/reperfusion endoplasmic reticulum stress. , 2017, Acta cirurgica brasileira.

[57]  Yan Zhang,et al.  Methane alleviates carbon tetrachloride induced liver injury in mice: anti-inflammatory action demonstrated by increased PI3K/Akt/GSK-3β-mediated IL-10 expression , 2017, Journal of Molecular Histology.

[58]  Sruthi Ramagiri,et al.  Remote limb ischemic post conditioning during early reperfusion alleviates cerebral ischemic reperfusion injury via GSK‐3&bgr;/CREB/ BDNF pathway , 2017, European journal of pharmacology.

[59]  Chul-woo Yang,et al.  Paricalcitol Pretreatment Attenuates Renal Ischemia-Reperfusion Injury via Prostaglandin E2 Receptor EP4 Pathway , 2017, Oxidative medicine and cellular longevity.

[60]  Josephine Herz,et al.  Sildenafil Enhances Quantity of Immature Neurons and Promotes Functional Recovery in the Developing Ischemic Mouse Brain , 2017, Developmental Neuroscience.

[61]  F. Nevens,et al.  Farnesoid X Receptor Activation Attenuates Intestinal Ischemia Reperfusion Injury in Rats , 2017, PloS one.

[62]  D. G. Mostafa,et al.  Neuroprotective effect of resveratrol against brain ischemia reperfusion injury in rats entails reduction of DJ-1 protein expression and activation of PI3K/Akt/GSK3b survival pathway , 2016, Archives of physiology and biochemistry.

[63]  C. Jobin,et al.  Murine Model of Intestinal Ischemia-reperfusion Injury. , 2016, Journal of visualized experiments : JoVE.

[64]  J. Koo,et al.  GSK-3α Is a Novel Target of CREB and CREB-GSK-3α Signaling Participates in Cell Viability in Lung Cancer , 2016, PloS one.

[65]  C. Chuang,et al.  Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury , 2015, BioMed research international.

[66]  T. Fields,et al.  Glycogen synthase kinase-3 inhibition attenuates fibroblast activation and development of fibrosis following renal ischemia-reperfusion in mice , 2015, Disease Models & Mechanisms.

[67]  M. Salvadori,et al.  Update on ischemia-reperfusion injury in kidney transplantation: Pathogenesis and treatment. , 2015, World journal of transplantation.

[68]  M. Sugimachi,et al.  An interaction between glucagon-like peptide-1 and adenosine contributes to cardioprotection of a dipeptidyl peptidase 4 inhibitor from myocardial ischemia-reperfusion injury. , 2015, American journal of physiology. Heart and circulatory physiology.

[69]  R. Jope,et al.  Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases. , 2015, Pharmacology & therapeutics.

[70]  G. Yoon,et al.  Transcriptional regulation of autophagy by an FXR/CREB axis , 2014, Nature.

[71]  Hailong Fu,et al.  Inhibition of glycogen synthase kinase 3 ameliorates liver ischemia/reperfusion injury via an energy-dependent mitochondrial mechanism. , 2014, Journal of hepatology.

[72]  Hongbin Sun,et al.  Protective Effects of Pretreatment with Oleanolic Acid in Rats in the Acute Phase of Hepatic Ischemia-Reperfusion Injury: Role of the PI3K/Akt Pathway , 2014, Mediators of inflammation.

[73]  R. Frozza,et al.  Berberine was neuroprotective against an in vitro model of brain ischemia: Survival and apoptosis pathways involved , 2014, Brain Research.

[74]  S. Ryter,et al.  Carbon Monoxide Protects against Hepatic Ischemia/Reperfusion Injury via ROS-Dependent Akt Signaling and Inhibition of Glycogen Synthase Kinase 3β , 2013, Oxidative medicine and cellular longevity.

[75]  P. Pawar,et al.  Metformin loaded non-ionic surfactant vesicles: optimization of formulation, effect of process variables and characterization , 2013, DARU Journal of Pharmaceutical Sciences.

[76]  J. Rao,et al.  Lithium exacerbates hepatic ischemia/reperfusion injury by inhibiting GSK-3β/NF-κB-mediated protective signaling in mice. , 2012, European journal of pharmacology.

[77]  A. Pagnussat,et al.  Resveratrol prevents CA1 neurons against ischemic injury by parallel modulation of both GSK‐3β and CREB through PI3‐K/Akt pathways , 2012, The European journal of neuroscience.

[78]  Xiaoling Zhang,et al.  Neuroprotection of early and short-time applying berberine in the acute phase of cerebral ischemia: Up-regulated pAkt, pGSK and pCREB, down-regulated NF-κB expression, ameliorated BBB permeability , 2012, Brain Research.

[79]  F. Gao,et al.  Activation of cyclic adenosine monophosphate–dependent protein kinase a signaling prevents liver ischemia/reperfusion injury in mice , 2012, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[80]  Sandeep R. Bhave,et al.  GSK-3β: A Bifunctional Role in Cell Death Pathways , 2012, International journal of cell biology.

[81]  Seongheon Lee,et al.  Curcumin Protects Against Regional Myocardial Ischemia/Reperfusion Injury Through Activation of RISK/GSK-3β and Inhibition of p38 MAPK and JNK , 2012, Journal of cardiovascular pharmacology and therapeutics.

[82]  M. Rosengart,et al.  Calcium/calmodulin-dependent protein kinase IV limits organ damage in hepatic ischemia-reperfusion injury through induction of autophagy. , 2012, American journal of physiology. Gastrointestinal and liver physiology.

[83]  D. Zorov,et al.  Inhibition of GSK-3β Decreases the Ischemia-Induced Death of Renal Cells , 2010, Bulletin of Experimental Biology and Medicine.

[84]  T. G. Singh,et al.  Involvement of cyclic adenosine diphosphoribose receptor activation in ischemic preconditioning induced protection in mouse brain , 2010, Brain Research.

[85]  H. G. Park,et al.  Estrogen-induced Bcl-2 expression after spinal cord injury is mediated through phosphoinositide-3-kinase/Akt-dependent CREB activation. , 2008, Journal of neurotrauma.

[86]  I. Kang,et al.  Activation of adenosine A3 receptor suppresses lipopolysaccharide-induced TNF-α production through inhibition of PI 3-kinase/Akt and NF-κB activation in murine BV2 microglial cells , 2006, Neuroscience Letters.

[87]  J. Perriard,et al.  Isoflurane Postconditioning Prevents Opening of the Mitochondrial Permeability Transition Pore through Inhibition of Glycogen Synthase Kinase 3β , 2005, Anesthesiology.

[88]  D. Fullerton,et al.  Dexmedetomidine, an α-2a adrenergic agonist, promotes ischemic tolerance in a murine model of spinal cord ischemia-reperfusion. , 2014, The Journal of thoracic and cardiovascular surgery.

[89]  P. Crack,et al.  Modulation of neuro-inflammation and vascular response by oxidative stress following cerebral ischemia-reperfusion injury. , 2008, Current medicinal chemistry.

[90]  L. Chao,et al.  Tissue kallikrein protects against pressure overload-induced cardiac hypertrophy through kinin B2 receptor and glycogen synthase kinase-3beta activation. , 2007, Cardiovascular research.

[91]  N. Maulik,et al.  Pharmacological preconditioning with resveratrol: role of CREB-dependent Bcl-2 signaling via adenosine A3 receptor activation. , 2005, American journal of physiology. Heart and circulatory physiology.

[92]  D. Chuang,et al.  Molecular Neuroscience Review Article Gsk-3 as a Target for Lithium-induced Neuroprotection against Excitotoxicity in Neuronal Cultures and Animal Models of Ischemic Stroke , 2022 .