The use of antimalarials in combination with other disease modifying agents in rheumatoid arthritis–the French Experience

A significant proportion of patients with rheumatoid arthritis have an aggressive, severe disease that may contribute to excess mortality. It has been suggested that early, aggressive therapy might improve the prognosis of these patients with active, severe rheumatoid arthritis. Combinations of disease modifying anti-rheumatic drugs including antimalarials are increasingly used in patients with active disease. While several open trials showed encouraging results, some controlled studies gave less support for the use of combination therapy. Ongoing controlled trials of double or triple combination therapy, such as hydroxychloroquine, methotrexate and sulphasalazine, should help define its place in treating patients with rheumatoid arthritis.

[1]  D. Mccarty,et al.  Combination drug therapy of seropositive rheumatoid arthritis. , 1995, The Journal of rheumatology.

[2]  J. O’dell.  Living with Arthritis. Tammi L. Schlotzhauer, James L. McGuire. Baltimore, Johns Hopkins University Press, 1993. 216 pp. Illustrated. Indexed. $22.95. , 1994 .

[3]  D. Felson,et al.  The efficacy and toxicity of combination therapy in rheumatoid arthritis. A meta-analysis. , 1994, Arthritis and rheumatism.

[4]  S. Eksborg,et al.  Chloroquine reduces the bioavailability of methotrexate in patients with rheumatoid arthritis. A possible mechanism of reduced hepatotoxicity. , 1994, Arthritis and rheumatism.

[5]  M. Ferraz,et al.  Combination therapy with methotrexate and chloroquine in rheumatoid arthritis. A multicenter randomized placebo-controlled trial. , 1994, Scandinavian journal of rheumatology.

[6]  R. Fox,et al.  Mechanism of action of hydroxychloroquine as an antirheumatic drug. , 1993, Seminars in arthritis and rheumatism.

[7]  J. Pødenphant,et al.  Hydroxychloroquine and sulphasalazine alone and in combination in rheumatoid arthritis: a randomised double blind trial. , 1993, Annals of the rheumatic diseases.

[8]  J. Gatterová,et al.  Combination therapy with hydroxychloroquine and methotrexate in rheumatoid arthritis. , 1993, Zeitschrift fur Rheumatologie.

[9]  J. Anaya,et al.  Possible efficacy of hydroxychloroquine on accelerated nodulosis during methotrexate therapy for rheumatoid arthritis. , 1993, The Journal of rheumatology.

[10]  J. Hunter,et al.  Combination therapy in rheumatoid arthritis--no benefit of addition of hydroxychloroquine to patients with a suboptimal response to intramuscular gold therapy. , 1993, The Journal of rheumatology.

[11]  T. M. Hansen,et al.  A double-blind comparative study of hydroxychloroquine and dapsone, alone and in combination, in rheumatoid arthritis. , 1993, Scandinavian journal of rheumatology.

[12]  M. Urowitz,et al.  Comparison of azathioprine, methotrexate, and the combination of both in the treatment of rheumatoid arthritis , 1992 .

[13]  M. Urowitz,et al.  Comparison of azathioprine, methotrexate, and the combination of both in the treatment of rheumatoid arthritis. A controlled clinical trial. , 1992, Arthritis and rheumatism.

[14]  G. Alarcón,et al.  Comparison of auranofin, methotrexate, and the combination of both in the treatment of rheumatoid arthritis. A controlled clinical trial. , 1992, Arthritis and rheumatism.

[15]  J. Clough,et al.  Therapy for rheumatoid arthritis: combinations of disease-modifying drugs and new paradigms of treatment. , 1991, Seminars in arthritis and rheumatism.

[16]  J. Fries,et al.  Aspirin, hydroxychloroquine, and hepatic enzyme abnormalities with methotrexate in rheumatoid arthritis. , 1990, Arthritis and rheumatism.

[17]  H. Paulus,et al.  The use of combinations of disease-modifying antirheumatic agents in rheumatoid arthritis. , 1990, Arthritis and rheumatism.

[18]  M. Ehrenfeld,et al.  Intractable RA--treatment with combined methotrexate, azathioprine and hydroxychloroquine. , 1989, British journal of rheumatology.

[19]  P. Bacon,et al.  Combination therapy with gold and hydroxychloroquine in rheumatoid arthritis: a prospective, randomized, placebo-controlled study. , 1989, British journal of rheumatology.

[20]  P. Emery,et al.  Combined D-penicillamine and chloroquine treatment of rheumatoid arthritis--a comparative study. , 1987, British journal of rheumatology.

[21]  V. Wright,et al.  Sulphasalazine alone or in combination with D-penicillamine in rheumatoid arthritis. , 1987, British journal of rheumatology.

[22]  N. Tiliakos.  Low dose cytotoxic drug combination therapy in intractable rheumatoid arthritis two years later , 1986 .

[23]  G. Carrera,et al.  Treatment of intractable rheumatoid arthritis with combined cyclophosphamide, azathioprine, and hydroxychloroquine. A follow-up study. , 1986, JAMA.

[24]  W. O'Fallon,et al.  Controlled trial of hydroxychloroquine and D-penicillamine singly and in combination in the treatment of rheumatoid arthritis. , 1984, Arthritis and rheumatism.

[25]  G. Carrera,et al.  Intractable rheumatoid arthritis. Treatment with combined cyclophosphamide, azathioprine, and hydroxychloroquine. , 1982, JAMA.

[26]  P. Dieppe,et al.  Serum concanavalin-A binding in rheumatoid arthritis. , 1982, Annals of the rheumatic diseases.