Metabolomics and molecular docking-directed antiarthritic study of the ethyl acetate extract from Celastrus orbiculatus Thunb.

[1]  X. Jia,et al.  Erteng Tongbi Decoction ameliorates collagen-induced arthritis in mice via modulating T cell differentiation and cytokines balance. , 2021, Journal of ethnopharmacology.

[2]  Bin Liu,et al.  Lactate metabolism in rheumatoid arthritis: Pathogenic mechanisms and therapeutic intervention with natural compounds. , 2022, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[3]  S. Arora,et al.  In silico prediction of phytoconstituents from Ehretia laevis targeting TNF-α in arthritis , 2021, Digital Chinese Medicine.

[4]  V. Ravindran,et al.  Safety of Long-Term Use of Four Common Conventional Disease Modifying Anti-Rheumatic Drugs in Rheumatoid Arthritis , 2021, The journal of the Royal College of Physicians of Edinburgh.

[5]  Sixing Huang,et al.  Role of Glutamine-Glutamate/GABA cycle and potential target GLUD2 in alleviation of rheumatoid arthritis by Tripterygium hypoglaucum (levl.) Hutch based on metabolomics and molecular pharmacology. , 2021, Journal of ethnopharmacology.

[6]  Zhenzhong Wang,et al.  Metabolomics analysis of the therapeutic effects of Qiwei Tongbi oral liquid on rheumatoid arthritis in rats. , 2021, Journal of pharmaceutical and biomedical analysis.

[7]  A. Fernie,et al.  Ultra-high-performance liquid chromatography high-resolution mass spectrometry variants for metabolomics research , 2021, Nature Methods.

[8]  Yueyue Li,et al.  Non-target metabolomic analysis reveals the therapeutic effect of Saposhnikovia divaricata decoction on collagen-induced arthritis rats. , 2021, Journal of ethnopharmacology.

[9]  Fangle Liu,et al.  5-Hydroxy-4-methoxycanthin-6-one alleviates dextran sodium sulfate-induced colitis in rats via regulation of metabolic profiling and suppression of NF-κB/p65 signaling pathway. , 2020, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[10]  Ronghua Liu,et al.  Dendropanax dentiger (Harms) Merr. root and its major constituents exert therapeutic effect on adjuvant-induced arthritis in rats. , 2020, Journal of ethnopharmacology.

[11]  Yie Hou Lee,et al.  FUNCTIONAL METABOLOMICS DECIPHER BIOCHEMICAL FUNCTIONS AND ASSOCIATED MECHANISMS UNDERLIE SMALL-MOLECULE METABOLISM. , 2020, Mass spectrometry reviews.

[12]  Kang-Hoon Kim,et al.  Anti-Inflammatory Activity of Diterpenoids from Celastrus orbiculatus in Lipopolysaccharide-Stimulated RAW264.7 Cells , 2020, Journal of immunology research.

[13]  S. Schülke,et al.  Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis , 2020, Cells.

[14]  Dai-Feng Lu,et al.  Serum amino acid metabolic profiles of ankylosing spondylitis by targeted metabolomics analysis , 2020, Clinical Rheumatology.

[15]  Na Yang,et al.  Comprehensive metabolomics analysis based on UPLC-Q/TOF-MSE and the anti-COPD effect of different parts of Celastrus orbiculatus Thunb. , 2020, RSC advances.

[16]  K. Chopra,et al.  Astaxanthin attenuates oxidative stress and inflammatory responses in complete Freund-adjuvant-induced arthritis in rats , 2019, Pharmacological Reports.

[17]  T. Alizadeh,et al.  An enzyme-free sensing platform based on molecularly imprinted polymer/MWCNT composite for sub-micromolar-level determination of pyruvic acid as a cancer biomarker , 2019, Analytical and Bioanalytical Chemistry.

[18]  Xiaotian Li,et al.  Therapeutic effects of gentiopicroside on adjuvant-induced arthritis by inhibiting inflammation and oxidative stress in rats. , 2019, International immunopharmacology.

[19]  Q. Zhang,et al.  Traditional uses, secondary metabolites, and pharmacology of Celastrus species - a review. , 2019, Journal of ethnopharmacology.

[20]  Yayun Qian,et al.  Celastrus Orbiculatus Extracts Inhibit the Metastasis through Attenuating PI3K/Akt/mTOR Signaling Pathway in Human Gastric Cance. , 2019, Anti-cancer agents in medicinal chemistry.

[21]  Hui Sun,et al.  Applications and potential mechanisms of herbal medicines for rheumatoid arthritis treatment: a systematic review , 2019, RSC advances.

[22]  Chong-Zhi Wang,et al.  Genkwanin ameliorates adjuvant-induced arthritis in rats through inhibiting JAK/STAT and NF-κB signaling pathways. , 2019, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[23]  Li Tao,et al.  Cytotoxic abietane and kaurane diterpenoids from Celastrus orbiculatus , 2019, Journal of Natural Medicines.

[24]  Zhiqiang Liu,et al.  Non-target metabonomic method provided new insights on the therapeutical mechanism of Gancao Fuzi decoction on rheumatoid arthritis rats. , 2019, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[25]  S. Wang,et al.  Methionine attenuates the intensity of rheumatoid arthritis by downregulating NF-κB and iNOS expression in neonatal rats , 2018, 3 Biotech.

[26]  N. Pavlos,et al.  Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies , 2018, Bone Research.

[27]  N. Che,et al.  LC-MS-based serum metabolomics reveals a distinctive signature in patients with rheumatoid arthritis , 2018, Clinical Rheumatology.

[28]  Fei Li,et al.  Anti-rheumatoid arthritis effects of traditional Chinese herb couple in adjuvant-induced arthritis in rats. , 2017, Journal of ethnopharmacology.

[29]  Yayun Qian,et al.  Anticancer efficacy of the ethyl acetate extract from the traditional Chinese medicine herb Celastrus orbiculatus against human gastric cancer. , 2017, Journal of ethnopharmacology.

[30]  Fengguo Xu,et al.  Influences of Normalization Method on Biomarker Discovery in Gas Chromatography-Mass Spectrometry-Based Untargeted Metabolomics: What Should Be Considered? , 2017, Analytical chemistry.

[31]  J. Trygg,et al.  Metabolite and Lipid Profiling of Biobank Plasma Samples Collected Prior to Onset of Rheumatoid Arthritis , 2016, PloS one.

[32]  Rachel E Rigsby,et al.  Using the PyMOL application to reinforce visual understanding of protein structure , 2016, Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology.

[33]  Jianbo Sun,et al.  Metabolomics based on liquid chromatography with mass spectrometry reveals the chemical difference in the stems and roots derived from Ephedra sinica. , 2015, Journal of separation science.

[34]  J. Smolen,et al.  Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges , 2015, Nature Reviews Rheumatology.

[35]  Guoqing Li,et al.  Anti-invasive effects of Celastrus Orbiculatus extract on interleukin-1 beta and tumour necrosis factor-alpha combination-stimulated fibroblast-like synoviocytes , 2014, BMC Complementary and Alternative Medicine.

[36]  Xiaoqing Chen,et al.  Olean-type triterpenes of Celastrus orbiculatus , 2012 .

[37]  G. Siuzdak,et al.  Innovation: Metabolomics: the apogee of the omics trilogy , 2012, Nature Reviews Molecular Cell Biology.

[38]  Ho Joon Park,et al.  Antinociceptive and hypnotic properties of Celastrus orbiculatus. , 2011, Journal of ethnopharmacology.

[39]  P. Efthimiou,et al.  Complementary and alternative medicine use in rheumatoid arthritis: proposed mechanism of action and efficacy of commonly used modalities , 2010, Rheumatology International.

[40]  Q. Shi,et al.  Chemical and Pharmacological Studies of the Plants from Genus Celastrus , 2009, Chemistry & biodiversity.

[41]  John C. Lindon,et al.  Analytical technologies for metabonomics and metabolomics, and multi-omic information recovery , 2008 .

[42]  J. Hutcheson,et al.  Bim deficiency leads to exacerbation and prolongation of joint inflammation in experimental arthritis. , 2006, Arthritis and rheumatism.

[43]  U. Wagner,et al.  The phosphatidylcholine/lysophosphatidylcholine ratio in human plasma is an indicator of the severity of rheumatoid arthritis: investigations by 31P NMR and MALDI-TOF MS. , 2005, Clinical biochemistry.

[44]  B. Hwang,et al.  Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production. , 2002, Journal of natural products.

[45]  F. Akbıyık,et al.  Elevated levels of nitrate in rheumatoid arthritis , 2001, Rheumatology International.

[46]  K. Eguchi,et al.  Increased nitric oxide levels in patients with rheumatoid arthritis. , 1996, The Journal of rheumatology.

[47]  P. Geusens,et al.  Long-term effect of omega-3 fatty acid supplementation in active rheumatoid arthritis. A 12-month, double-blind, controlled study. , 1994, Arthritis and rheumatism.

[48]  J. Kremer.  n-3 fatty acid supplements in rheumatoid arthritis. , 2000, The American journal of clinical nutrition.