DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe.

[1]  Yi Zhou,et al.  DNA-dependent Protein Kinase Regulates DNA End Resection in Concert with Mre11-Rad50-Nbs1 (MRN) and Ataxia Telangiectasia-mutated (ATM)* , 2013, The Journal of Biological Chemistry.

[2]  I. Hickson,et al.  How unfinished business from S‐phase affects mitosis and beyond , 2013, The EMBO journal.

[3]  L. Staudt,et al.  Identification of Early Replicating Fragile Sites that Contribute to Genome Instability , 2013, Cell.

[4]  Y. Zou,et al.  DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair , 2012, Oncogene.

[5]  S. Opiyo,et al.  Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress , 2012, Nucleic acids research.

[6]  K. Myung,et al.  DNA-PK-Dependent RPA2 Hyperphosphorylation Facilitates DNA Repair and Suppresses Sister Chromatid Exchange , 2011, PloS one.

[7]  R. Hromas,et al.  More forks on the road to replication stress recovery. , 2011, Journal of molecular cell biology.

[8]  M. Lieber,et al.  The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. , 2010, Annual review of biochemistry.

[9]  S. Gonzalo,et al.  The role of RPA2 phosphorylation in homologous recombination in response to replication arrest. , 2010, Carcinogenesis.

[10]  G. Oakley,et al.  Replication protein A: directing traffic at the intersection of replication and repair. , 2010, Frontiers in bioscience.

[11]  N. Osheroff,et al.  Metnase promotes restart and repair of stalled and collapsed replication forks , 2010, Nucleic acids research.

[12]  R. Kanaar,et al.  Dealing with DNA damage: relationships between checkpoint and repair pathways. , 2010, Mutation research.

[13]  M. Jasin,et al.  Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis , 2010, Nature Reviews Molecular Cell Biology.

[14]  J. Borowiec,et al.  Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stress , 2009, Journal of Cell Science.

[15]  David J. Chen,et al.  DNA-PKcs and ATM co-regulate DNA double-strand break repair. , 2009, DNA repair.

[16]  J. Lupski,et al.  Mechanisms of change in gene copy number , 2009, Nature Reviews Genetics.

[17]  J. Haber,et al.  Replicon Dynamics, Dormant Origin Firing, and Terminal Fork Integrity after Double-Strand Break Formation , 2009, Cell.

[18]  J. Borowiec,et al.  Mitotic crisis: The unmasking of a novel role for RPA , 2009, Cell cycle.

[19]  R. Ullrich,et al.  DNA-PKcs and ATM influence generation of ionizing radiation-induced bystander signals , 2008, Oncogene.

[20]  M. P. Carty,et al.  Enhanced DNA-PK-mediated RPA2 hyperphosphorylation in DNA polymerase eta-deficient human cells treated with cisplatin and oxaliplatin. , 2008, DNA repair.

[21]  J. Nickoloff,et al.  Regulation of DNA double-strand break repair pathway choice , 2008, Cell Research.

[22]  R. Kanaar,et al.  Mechanisms of Dealing with DNA Damage-Induced Replication Problems , 2008, Cell Biochemistry and Biophysics.

[23]  T. Paull,et al.  Activation and regulation of ATM kinase activity in response to DNA double-strand breaks , 2007, Oncogene.

[24]  J. Borowiec,et al.  Sequential and Synergistic Modification of Human RPA Stimulates Chromosomal DNA Repair* , 2007, Journal of Biological Chemistry.

[25]  S. Opiyo,et al.  NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse , 2007, Journal of Cell Science.

[26]  K. Cimprich,et al.  The ATR pathway: fine-tuning the fork. , 2007, DNA repair.

[27]  A. Shevchenko,et al.  Ataxia-telangiectasia Mutated (ATM)-dependent Activation of ATR Occurs through Phosphorylation of TopBP1 by ATM* , 2007, Journal of Biological Chemistry.

[28]  B. A. Ballif,et al.  ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage , 2007, Science.

[29]  David M. Wilson,et al.  Molecular mechanisms of sister-chromatid exchange. , 2007, Mutation research.

[30]  F. Bunz,et al.  ATM and ATR: Components of an Integrated Circuit , 2007, Cell cycle.

[31]  Zhiyuan Shen.  Mammalian homologous recombination repair and cancer intervention , 2007 .

[32]  E. Fanning,et al.  RPA2 Is a Direct Downstream Target for ATR to Regulate the S-phase Checkpoint* , 2006, Journal of Biological Chemistry.

[33]  D. Weinstock,et al.  Modeling oncogenic translocations: distinct roles for double-strand break repair pathways in translocation formation in mammalian cells. , 2006, DNA repair.

[34]  B. Chen,et al.  ATR-Dependent Phosphorylation of DNA-Dependent Protein Kinase Catalytic Subunit in Response to UV-Induced Replication Stress , 2006, Molecular and Cellular Biology.

[35]  J. Myers,et al.  Rapid Activation of ATR by Ionizing Radiation Requires ATM and Mre11* , 2006, Journal of Biological Chemistry.

[36]  Jiri Bartek,et al.  ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks , 2006, Nature Cell Biology.

[37]  Y. Zou,et al.  Preferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damage. , 2005, The Biochemical journal.

[38]  J. Bartek,et al.  Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage , 2005, Molecular and Cellular Biology.

[39]  Stephen P. Jackson,et al.  Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage , 2005, Nature.

[40]  M. Lavin,et al.  Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM. , 2005, Cancer research.

[41]  Jean Gautier,et al.  ATM and ATR Check in on Origins: A Dynamic Model for Origin Selection and Activation , 2005, Cell cycle.

[42]  F. Alt,et al.  Control of sister chromatid recombination by histone H2AX. , 2004, Molecular cell.

[43]  S. Powell,et al.  The interaction of p53 with replication protein A mediates suppression of homologous recombination , 2004, Oncogene.

[44]  J. Gautier,et al.  ATR and ATM regulate the timing of DNA replication origin firing , 2004, Nature Cell Biology.

[45]  P. Jeggo,et al.  ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation , 2004, Cancer Research.

[46]  S. Lees-Miller,et al.  Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21. , 2004, Nucleic acids research.

[47]  T. Jacks,et al.  RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult. , 2004, Nucleic acids research.

[48]  Kai Rothkamm,et al.  A Double-Strand Break Repair Defect in ATM-Deficient Cells Contributes to Radiosensitivity , 2004, Cancer Research.

[49]  Ian D. Hickson,et al.  The Bloom's syndrome helicase suppresses crossing over during homologous recombination , 2003, Nature.

[50]  D. Baltimore,et al.  Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. , 2003, Genes & development.

[51]  M. Kastan,et al.  DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation , 2003, Nature.

[52]  T. Helleday,et al.  Different Roles for Nonhomologous End Joining and Homologous Recombination following Replication Arrest in Mammalian Cells , 2002, Molecular and Cellular Biology.

[53]  David J. Chen,et al.  DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[54]  J. Nickoloff.  Recombination: Mechanisms and Roles in Tumorigenesis , 2002 .

[55]  C. Limoli,et al.  UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, γ-H2AX formation, and Mre11 relocalization , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[56]  G. Iliakis,et al.  Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase. , 2001, Cancer research.

[57]  K. Khanna,et al.  UV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein. , 2001, Molecular biology of the cell.

[58]  T. Helleday,et al.  DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells. , 2001, Journal of molecular biology.

[59]  T. Helleday,et al.  Inhibition of DNA synthesis is a potent mechanism by which cytostatic drugs induce homologous recombination in mammalian cells. , 2000, Mutation research.

[60]  A. Shinohara,et al.  The controlling role of ATM in homologous recombinational repair of DNA damage , 2000, The EMBO journal.

[61]  Yuko Yamaguchi-Iwai,et al.  Sister Chromatid Exchanges Are Mediated by Homologous Recombination in Vertebrate Cells , 1999, Molecular and Cellular Biology.

[62]  K. Kohn,et al.  Replication‐mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA‐dependent protein kinase and dissociates RPA:DNA‐PK complexes , 1999, The EMBO journal.

[63]  C. Anderson,et al.  Sites of UV-induced Phosphorylation of the p34 Subunit of Replication Protein A from HeLa Cells* , 1997, The Journal of Biological Chemistry.

[64]  S. Powell,et al.  High Frequency and Error-prone DNA Recombination in Ataxia Telangiectasia Cell Lines (*) , 1996, The Journal of Biological Chemistry.