Biosensor development at the University of Utah

Describes three biosensors: a silicon retina chip, CHEMFET sensors and an optical immunoassay chip utilizing a planar waveguide. These three examples of sensors give a small flavor of the biosensor work ongoing at the University of Utah. Although there are obvious differences between each of these three sensors in terms of their application areas, the parameters measured, and the technologies used, there are several similarities that are shared by many biosensor developments. These include the move toward smaller device sizes, inexpensive fabrication, large-scale manufacturing methods, and improved reliability in actual applications. The extent to which each of these sensors can meet those real-world requirements will largely determine their eventual commercial viability.<<ETX>>

[1]  F. Werblin,et al.  Control of Retinal Sensitivity: I. Light and Dark Adaptation of Vertebrate Rods and Cones , 1974 .

[2]  Xizhong Li,et al.  Enhanced Lifetime and Adhesion of K+‐, NH 4 + ‐, and Ca2+‐Sensitive Membranes on Solid Surfaces Using Hydroxyl‐Modified Polyvinylchloride Matrices , 1988 .

[3]  J. Janata,et al.  Encapsulation of polymeric membrane-based ion-selective field effect transistors , 1983 .

[4]  Giulio Sandini,et al.  A Foveated Retina-Like Sensor Using CCD Technology , 1989, Analog VLSI Implementation of Neural Systems.

[5]  J. Janata,et al.  Temperature-controlled Kelvin microprobe , 1993 .

[6]  R. Normann,et al.  A three-dimensional architecture for a parallel processing photosensing array (silicon retina application) , 1992, IEEE Transactions on Biomedical Engineering.

[7]  J. Janata,et al.  Multisensing ion-selective field-effect transistors prepared by ionophore doping technique. , 1987, Analytical chemistry.

[8]  J. Janata,et al.  Suspended gate field-effect transistor sensitive to gaseous hydrogen cyanide† , 1993 .

[9]  W. Kern,et al.  Advances in deposition processes for passivation films , 1977 .

[10]  Shellee D. Dyer,et al.  Analysis of excitation and collection geometries for planar waveguide immunosensors , 1993, Photonics West - Lasers and Applications in Science and Engineering.

[11]  F. Werblin.  Control of Retinal Sensitivity II . Lateral Interactions at the Outer Plexiform Layer , 2022 .

[12]  Nonequilibrium morphology of liquid inclusions migrating in solids , 1977 .

[13]  Mira Josowicz,et al.  Present state of fabrication of chemically sensitive field effect transistors : plenary lecture , 1993 .

[14]  Andreas G. Andreou,et al.  Current-mode subthreshold MOS circuits for analog VLSI neural systems , 1991, IEEE Trans. Neural Networks.

[15]  P. Janata,et al.  Electrochemical encapsulation for sensors , 1989 .

[16]  R. Normann,et al.  The effects of background illumination on the photoresponses of red and green cones. , 1979, The Journal of physiology.

[17]  Shellee D. Dyer,et al.  Fluorescent immunosensors using planar waveguides , 1993, Photonics West - Lasers and Applications in Science and Engineering.

[18]  Andreas G. Andreou,et al.  A Contrast Sensitive Silicon Retina with Reciprocal Synapses , 1991, NIPS.

[19]  J. Janata,et al.  Effect of thermal treatment of passivation integrity of chemical vapor deposition silicon nitride , 1992 .

[20]  T. R. Anthony,et al.  Stresses generated by the thermomigration of liquid inclusions in silicon , 1978 .