Challenges and Perspectives in the Use of Additive Technologies for Making Customized Implants for Traumatology and Orthopedics

The development of personalized medicine throughout the world is linked with advances in basic sciences such as genetics and biochemistry. This relates primarily to the creation of technologies for targeted highefficacy treatment of cancers. The potential for fast and accessible individualized preparation of medical devices, medicines, and even organs has appeared with the application of 3D printers to medicine. Could the personalized approach to making osteointegrated implants for traumatology and orthopedics lead to the development of hightech products based primarily on additive technologies? And would customized implants be able to improve the care of patients requiring surgical treatment? Answers to these questions require close interaction between surgeons, healthcare administrators, materials engineers, and technologists. And even if we gain an understanding of the needs, implementation of projects of this type will involve legal and economic conditions whose complexity could well become a barrier to their introduction.

[1]  Predrag Sukovic,et al.  Accuracy of implant placement with a stereolithographic surgical guide. , 2003, The International journal of oral & maxillofacial implants.

[2]  Brian Derby,et al.  Printing and Prototyping of Tissues and Scaffolds , 2012, Science.

[3]  Nicholas Herbert,et al.  A preliminary investigation into the development of 3-D printing of prosthetic sockets. , 2005, Journal of rehabilitation research and development.

[4]  Tomiharu Matsushita,et al.  Effect of pore size on bone ingrowth into porous titanium implants fabricated by additive manufacturing: An in vivo experiment. , 2016, Materials science & engineering. C, Materials for biological applications.

[5]  A. Bandyopadhyay,et al.  Bone tissue engineering using 3D printing , 2013 .

[6]  Paul S D'Urso,et al.  Biomodeling as an Aid to Spinal Instrumentation , 2004, Spine.

[7]  D. Kaplan,et al.  Porosity of 3D biomaterial scaffolds and osteogenesis. , 2005, Biomaterials.

[8]  Udayabhanu M. Jammalamadaka,et al.  Antibiotic and chemotherapeutic enhanced three-dimensional printer filaments and constructs for biomedical applications , 2015, International journal of nanomedicine.

[9]  Wei Xu,et al.  Topological design and additive manufacturing of porous metals for bone scaffolds and orthopaedic implants: A review. , 2016, Biomaterials.

[10]  Nicholas B Langhals,et al.  Innovations in Prosthetic Interfaces for the Upper Extremity , 2013, Plastic and reconstructive surgery.

[11]  D. Wise,et al.  Developing porosity of poly(propylene glycol-co-fumaric acid) bone graft substitutes and the effect on osteointegration: A preliminary histology study in rats , 2000, Journal of biomaterials science. Polymer edition.

[12]  Brad M Isaacson,et al.  Osseointegration: a review of the fundamentals for assuring cementless skeletal fixation , 2014 .

[13]  George A. Brown,et al.  Rapid 3-dimensional prototyping for surgical repair of maxillofacial fractures: a technical note. , 2004, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.