Increased Resistance and Selection in Paclitaxel for Peripheral Blood Progenitor Cells Following Transduction with the MDR1 Gene

Einleitung: Methode: Ergebnisse: in vitro Schlußfolgerung: in vitro Introduction: Methods: Results: in vitro Conclusion: in vitro

[1]  S. Seeber,et al.  Transfer of the cytidine deaminase cDNA into hematopoietic cells. , 1999, Leukemia research.

[2]  I. Pastan,et al.  Retroviral transfer of human MDR1 gene to hematopoietic cells: effects of drug selection and of transcript splicing on expression of encoded P-glycoprotein. , 1999, Human gene therapy.

[3]  C. Salata,et al.  A clinical trial of retroviral-mediated transfer of a rev-responsive element decoy gene into CD34(+) cells from the bone marrow of human immunodeficiency virus-1-infected children. , 1999, Blood.

[4]  I. Pastan,et al.  Engraftment of MDR1 and NeoR gene-transduced hematopoietic cells after breast cancer chemotherapy. , 1999, Blood.

[5]  W. Wilson,et al.  Paclitaxel chemotherapy after autologous stem-cell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multidrug resistance complementary DNA (MDR1) in metastatic breast cancer patients. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

[6]  B. Torbett,et al.  Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors. , 1999, Science.

[7]  R. Ashmun,et al.  In vivo selection of retrovirally transduced hematopoietic stem cells , 1998, Nature Medicine.

[8]  B. Sorrentino,et al.  Transduction of murine bone marrow cells with an MDR1 vector enables ex vivo stem cell expansion, but these expanded grafts cause a myeloproliferative syndrome in transplanted mice. , 1998, Blood.

[9]  C. Macdonald,et al.  Feasibility of multidrug resistance (MDR-1) gene transfer in patients undergoing high-dose therapy and peripheral blood stem cell transplantation for lymphoma , 1998, Gene Therapy.

[10]  David A. Williams,et al.  Optimization of fibronectin-assisted retroviral gene transfer into human CD34+ hematopoietic cells. , 1997, Human gene therapy.

[11]  S. Hegewisch-Becker,et al.  High-dose multidrug resistance in primary human hematopoietic progenitor cells transduced with optimized retroviral vectors. , 1996, Blood.

[12]  N. Eliopoulos,et al.  Resistance to cytosine arabinoside by retrovirally mediated gene transfer of human cytidine deaminase into murine fibroblast and hematopoietic cells. , 1996, Cancer gene therapy.

[13]  S. Hegewisch-Becker,et al.  Novel retroviral vectors for efficient expression of the multidrug resistance (mdr-1) gene in early hematopoietic cells , 1995, Journal of virology.

[14]  S. Hegewisch-Becker,et al.  Chemotherapy resistance to taxol in clonogenic progenitor cells following transduction of CD34 selected marrow and peripheral blood cells with a retrovirus that contains the MDR-1 chemotherapy resistance gene. , 1995, Gene therapy.

[15]  S. Rosenberg,et al.  T Lymphocyte-Directed Gene Therapy for ADA− SCID: Initial Trial Results After 4 Years , 1995, Science.

[16]  Evelina Mazzolari,et al.  Gene Therapy in Peripheral Blood Lymphocytes and Bone Marrow for ADA− Immunodeficient Patients , 1995, Science.

[17]  K. McDonagh,et al.  Expression of retroviral vectors containing the human multidrug resistance 1 cDNA in hematopoietic cells of transplanted mice. , 1995, Blood.

[18]  David A. Williams,et al.  Retrovirus-mediated expression of a DNA repair protein in bone marrow protects hematopoietic cells from nitrosourea-induced toxicity in vitro and in vivo. , 1995, Cancer research.

[19]  S. Mineishi,et al.  Ex vivo expansion and selection of human CD34+ peripheral blood progenitor cells after introduction of a mutated dihydrofolate reductase cDNA via retroviral gene transfer. , 1995, Blood.

[20]  F. Malavasi,et al.  Retrovirus‐mediated transfer of the multidrug resistance gene into human haemopoietic progenitor cells , 1994, British journal of haematology.

[21]  S. Goff,et al.  Transfer and expression of the human multiple drug resistance gene in human CD34+ cells. , 1994, Blood.

[22]  Moore Ma,et al.  Regulation and function of hematopoietic stem cells. , 1994, Current opinion in hematology.

[23]  David A. Williams,et al.  Bone marrow extracellular matrix molecules improve gene transfer into human hematopoietic cells via retroviral vectors. , 1994, The Journal of clinical investigation.

[24]  J. Ihle,et al.  Gene marking to determine whether autologous marrow infusion restores long-term haemopoiesis in cancer patients , 1993, The Lancet.

[25]  I. Pastan,et al.  Transfer and expression of the human multiple drug resistance gene into live mice. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[26]  I. Pastan,et al.  Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1. , 1992, Science.

[27]  D. Williams,et al.  Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow , 1987, The Journal of experimental medicine.

[28]  A. Miller,et al.  Retrovirus-mediated transfer and expression of drug resistance genes in human haematopoietic progenitor cells , 1986, Nature.

[29]  J. Dick,et al.  Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/Wv mice , 1985, Cell.

[30]  A. Joyner,et al.  Retrovirus transfer of a bacterial gene into mouse haematopoietic progenitor cells , 1983, Nature.

[31]  J. Leonard,et al.  Retroviral transduction of human CD34+ umbilical cord blood progenitor cells with a mutated dihydrofolate reductase cDNA. , 1998, Human gene therapy.

[32]  S. Hegewisch-Becker,et al.  Dominant selection of hematopoietic progenitor cells with retroviral MDR1 co-expression vectors. , 1998, Human gene therapy.

[33]  A. Kaubisch,et al.  Phase I trial of retroviral-mediated transfer of the human MDR1 gene as marrow chemoprotection in patients undergoing high-dose chemotherapy and autologous stem-cell transplantation. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[34]  E. Gilboa,et al.  Development of a retroviral construct containing a human mutated dihydrofolate reductase cDNA for hematopoietic stem cell transduction. , 1994, Blood.

[35]  M. Moore,et al.  Ex vivo expansion of cord blood-derived stem cells and progenitors. , 1994, Blood cells.

[36]  A. Nienhuis,et al.  Efficient retrovirus transduction of mouse pluripotent hematopoietic stem cells mobilized into the peripheral blood by treatment with granulocyte colony-stimulating factor and stem cell factor. , 1994, Blood.