Corrosive-Induced Carcinoma of Esophagus: Esophagographic and CT Findings.

OBJECTIVE The purpose of this study was to evaluate the esophagographic and CT findings of corrosive esophageal cancer. MATERIALS AND METHODS The records of all patients who presented with corrosive esophageal strictures at one institution between June 1989 and April 2015 were retrospectively identified. The search yielded the records of 15 patients with histopathologically proven esophageal cancer. Esophagograms (13 patients) and chest CT images (14 patients) were interpreted independently by two reviewers. Esophagographic findings included the location of tumor, morphologic type, presence and length of mucosal irregularity, presence of asymmetric involvement, and presence of rigidity. CT findings included presence and type of esophageal wall thickening, pattern of enhancement, presence of periesophageal infiltration, and presence of hilar or mediastinal lymphadenopathy. RESULTS Esophagography showed that the tumor was involved with the stenotic portion in 10 of the 13 patients (76.9%). The most common morphologic feature was a polypoid mass, in 10 patients. In 12 patients (92.3%), mucosal irregularities were observed; the mean affected length was 4.92 cm. Asymmetric involvement and rigidity were observed in nine patients (69.2%). On CT scans, eccentric wall thickening was observed in 10 of the 14 patients (71.4%), homogeneous enhancement in nine (64.2%), and periesophageal infiltration in 11 (78.5%). CONCLUSION Esophagography commonly shows corrosive esophageal cancer as a polypoid mass with long-segment mucosal irregularities at the stenotic portion, asymmetric involvement, and rigidity. CT shows eccentric esophageal wall thickening with homogeneous enhancement and periesophageal infiltration, which are suggestive of the development of malignancy in patients with corrosive esophageal strictures.

[1]  P. Cattan,et al.  The Damage Pattern to the Gastrointestinal Tract Depends on the Nature of the Ingested Caustic Agent , 2016, World Journal of Surgery.

[2]  Xun Zhang,et al.  Corrosive induced carcinoma of esophagus after 58 years. , 2012, The Annals of thoracic surgery.

[3]  L. Giacomelli,et al.  Caustic ingestion and oesophageal cancer: intra- and peri-tumoral fibrosis is associated with a better prognosis. , 2010, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[4]  P. Sethy,et al.  Corrosive induced carcinoma of esophagus: Report of three patients and review of literature , 2006, Journal of gastroenterology and hepatology.

[5]  Õ. Horváth,et al.  [Late malignant transformation of chronic corrosive oesophageal strictures]. , 2005, Magyar sebeszet.

[6]  P. Kim,et al.  Superficial esophageal cancer: esophagographic findings correlated with histopathologic findings. , 2005, Radiology.

[7]  R. Iyer,et al.  Imaging of esophageal cancer , 2004, Cancer imaging : the official publication of the International Cancer Imaging Society.

[8]  M. Hellier Message from the President of the Section of Digestive Endoscopy of the British Society of Gastroenterology , 1999 .

[9]  R. Kochhar,et al.  Carcinoma developing in a patient with longstanding lye stricture of oesophagus. , 1989, The Journal of the Association of Physicians of India.

[10]  R. Hopkins,et al.  Caustic Burns and Carcinoma of the Esophagus , 1981, Annals of surgery.

[11]  P. Appelqvist,et al.  Lye corrosion carcinoma of the esophagus. A review of 63 cases , 1980, Cancer.

[12]  J. Imre,et al.  Arguments against long-term conservative treatment of oesophageaĺ strictures due to corrosive burns , 1972, Thorax.

[13]  G. E. Tennekoon,et al.  Squamous Carcinoma of the Stomach Following Corrosive Acid Burns , 1972, The British journal of surgery.

[14]  J. W. Pate,et al.  Carcinoma of the esophagus engrafted on lye stricture. , 1971, Chest.

[15]  J. Ochsner,et al.  Carcinoma of the esophagus at the site of lye stricture. , 1969, American journal of surgery.

[16]  Nolton H. Blgelow Carcinoma of the esophagus developing at the site of lye stricture , 1953 .

[17]  U. Kiviranta Corrosion carcinoma of the esophagus; 381 cases of corrosion and nine cases of corrosion carcinoma. , 1952, Acta oto-laryngologica.

[18]  Bigger Ia,et al.  Carcinoma secondary to burn of the esophagus from ingestion of lye; report of a case. , 1950 .