Obesity, overweight and patterns of osteoarthritis: the Ulm Osteoarthritis Study.

The objective of this study was to assess the association between obesity and osteoarthritis (OA) of the knee, hip, and hand. OA patterns were studied in 809 patients with knee or hip joint replacement due to OA. Patients with OA were categorized as having bilateral or generalized OA according to the presence of radiographic OA in the contralateral joint or different finger joints, and as normal weight, overweight, or obese according to their body mass index (BMI). Odds ratios (OR) and 95% confidence intervals (CI) for relative weight and OA patterns were estimated with multivariable logistic regression. Eighty-five percent of participants had bilateral OA, 26% had generalized OA, and 31% were obese. Obesity (BMI >/= 30 kg/m(2); OR = 8.1; 95% CI: 2.4-28) and overweight (BMI >/= 25 kg/m(2); OR = 5.9; 95% CI: 2.0-18) were strongly associated with bilateral knee OA. No association between obesity and bilateral hip OA (OR = 0.7; 95% CI: 0.3-1.7) nor generalized OA (OR = 1.1; 95% CI: 0.6-2.1) was observed. Obesity seems to be a mechanical rather than a systemic risk factor for OA with the knee joint being especially susceptible.

[1]  A. Svanborg,et al.  Factors associated with radiographic osteoarthritis: results from the population study 70-year-old people in Göteborg. , 1991, The Journal of rheumatology.

[2]  M Lequesne,et al.  Atlas of individual radiographic features in osteoarthritis. , 1995, Osteoarthritis and cartilage.

[3]  H. Valkenburg,et al.  A 12 year follow up study in the general population on prognostic factors of cartilage loss in osteoarthritis of the knee. , 1992, Annals of the rheumatic diseases.

[4]  D. Felson,et al.  Weight Loss Reduces the Risk for Symptomatic Knee Osteoarthritis in Women , 1992, Annals of Internal Medicine.

[5]  T. Spector,et al.  Defining osteoarthritis of the hand for epidemiological studies: the Chingford Study. , 1994, Annals of the rheumatic diseases.

[6]  M. Nevitt,et al.  The association of radiographic changes of osteoarthritis of the hand and hip in elderly women. , 1995, The Journal of rheumatology.

[7]  M. Sowers,et al.  Association of bone mineral density and sex hormone levels with osteoarthritis of the hand and knee in premenopausal women. , 1996, American journal of epidemiology.

[8]  T. Spector,et al.  Association between metabolic factors and knee osteoarthritis in women: the Chingford Study. , 1995, The Journal of rheumatology.

[9]  H. Malchau,et al.  Lifestyle factors and hip arthrosis. A case referent study of body mass index, smoking and hormone therapy in 503 Swedish women. , 1997, Acta orthopaedica Scandinavica.

[10]  T. Spector,et al.  DEFINING OSTEOARTHRITIS OF THE HAND FOR EPIDEMIOLOGIC STUDIES , 1993 .

[11]  L. Alfredsson,et al.  Etiologic fractions for physical work load, sports and overweight in the occurrence of coxarthrosis. , 1994, Scandinavian journal of work, environment & health.

[12]  A. Aromaa,et al.  Association of overweight, trauma and workload with coxarthrosis. A health survey of 7,217 persons. , 1993, Acta orthopaedica Scandinavica.

[13]  Daniel Levy,et al.  Risk factors for incident radiographic knee osteoarthritis in the elderly: the Framingham Study. , 1997, Arthritis and rheumatism.

[14]  T. Spector,et al.  The relationship of obesity, fat distribution and osteoarthritis in women in the general population: the Chingford Study. , 1993, The Journal of rheumatology.

[15]  D Coggon,et al.  Individual risk factors for hip osteoarthritis: obesity, hip injury, and physical activity. , 1998, American journal of epidemiology.

[16]  T. Spector,et al.  Radiographic criteria for epidemiologic studies of osteoarthritis. , 1995, The Journal of rheumatology. Supplement.

[17]  J. Neuhaus,et al.  Obesity and osteoarthritis of the knee: evidence from the National Health and Nutrition Examination Survey (NHANES I). , 1990, Seminars in arthritis and rheumatism.

[18]  T. Spector,et al.  Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women: the Chingford Study. , 1999, Arthritis and rheumatism.

[19]  Docteur Paul G. J. Maquet,et al.  Biomechanics of the Knee , 1984, Springer Berlin Heidelberg.

[20]  T. Spector,et al.  Incidence and progression of osteoarthritis in women with unilateral knee disease in the general population: the effect of obesity. , 1994, Annals of the rheumatic diseases.

[21]  J. Kellgren,et al.  Radiological Assessment of Osteo-Arthrosis , 1957, Annals of the rheumatic diseases.

[22]  D. Felson Weight and osteoarthritis. , 1995, The American journal of clinical nutrition.

[23]  H. Riihimäki,et al.  Overweight, gender and knee osteoarthritis. , 1996, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

[24]  M. Hochberg,et al.  New radiographic grading scales for osteoarthritis of the hand. Reliability for determining prevalence and progression. , 1989, Arthritis and rheumatism.

[25]  K. Schwarz The Chingford Study. , 1981, Public health.

[26]  M. Hochberg,et al.  The association of body weight, body fatness and body fat distribution with osteoarthritis of the knee: data from the Baltimore Longitudinal Study of Aging. , 1995, The Journal of rheumatology.

[27]  M. Liang,et al.  The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. , 1988, Arthritis and rheumatism.

[28]  H. Brenner,et al.  Serum cholesterol and osteoarthritis. The baseline examination of the Ulm Osteoarthritis Study. , 1998, The Journal of rheumatology.

[29]  M. Hochberg,et al.  Factors associated with hip osteoarthritis: data from the First National Health and Nutrition Examination Survey (NHANES-I). , 1993, American journal of epidemiology.

[30]  P. Duby,et al.  [Biomechanical contribution to the study of equilibrium conditions in the normal and pathological knee. Use in the treatment of varus arthrosis. Preliminary notes]. , 1971, Acta orthopaedica Belgica.

[31]  Hermann Brenner,et al.  Reliability of radiographic grading of osteoarthritis of the hip and knee. , 1997, Scandinavian journal of rheumatology.

[32]  N. Bellamy,et al.  Validation study of WOMAC : a health status instrument for measuring clinically-important patient-relevant outcomes following total hip or knee arthroplasty in osteoarthritis , 1988 .

[33]  Obesity in Adults,et al.  Identification, Evaluation, and Treatment of Overweight and Obesity , 2021, Obesity Prevention and Treatment.

[34]  T. Stürmer,et al.  Prevalence of generalised osteoarthritis in patients with advanced hip and knee osteoarthritis: The Ulm Osteoarthritis Study , 1998, Annals of the rheumatic diseases.

[35]  J. S. Lawrence,et al.  The Epidemiology of Chronic Rheumatism , 1964 .

[36]  R. Moskowitz,et al.  Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. , 1986, Arthritis and rheumatism.

[37]  F. Arnett Revised criteria for the classification of rheumatoid arthritis. , 1990, Orthopedic nursing.

[38]  R. Hirsch,et al.  Association of hand and knee osteoarthritis: evidence for a polyarticular disease subset. , 1996, Annals of the rheumatic diseases.

[39]  D. Felson,et al.  Body weight, body mass index, and incident symptomatic osteoarthritis of the hand, hip, and knee. , 1999, Epidemiology.

[40]  D. Felson,et al.  Obesity and knee osteoarthritis. The Framingham Study. , 1988, Annals of internal medicine.

[41]  M. Sowers,et al.  Obesity as a risk factor for osteoarthritis of the hand and wrist: a prospective study. , 1994, American journal of epidemiology.

[42]  D. Felson Obesity and osteoarthritis of the knee. , 1992, Bulletin on the rheumatic diseases.

[43]  M. Doherty,et al.  Muscle weakness in osteoarthritis. , 1997, Current opinion in rheumatology.

[44]  Friedrich Pauwels,et al.  Biomechanics of the Locomotor Apparatus , 1980 .

[45]  R. Wasnich,et al.  Factors associated with joint pain among postmenopausal women , 1997, International Journal of Obesity.

[46]  T. Spector,et al.  Risk factors for osteoarthritis in the tibiofemoral and patellofemoral joints of the knee. , 1997, The Journal of rheumatology.

[47]  J. Neuhaus,et al.  The role of metabolic factors and blood pressure in the association of obesity with osteoarthritis of the knee. , 1988, The Journal of rheumatology.