Osseoperception in Dental Implants: A Systematic Review.

PURPOSE Replacement of lost teeth has significant functional and psychosocial effects. The capability of osseointegrated dental implants to transmit a certain amount of sensibility is still unclear. The phenomenon of developing a certain amount of tactile sensibility through osseointegrated dental implants is called osseoperception. The aim of this article is to evaluate the available literature to find osseoperception associated with dental implants. MATERIALS AND METHODS To identify suitable literature, an electronic search was performed using Medline and PubMed database. Articles published in English and articles whose abstract is available in English were included. The articles included in the review were based on osseoperception, tactile sensation, and neurophysiological mechanoreceptors in relation to dental implants. Articles on peri-implantitis and infection-related sensitivity were not included. Review articles without the original data were excluded, although references to potentially pertinent articles were noted for further follow-up. The phenomenon of osseoperception remains a matter of debate, so the search strategy mainly focused on articles on osseoperception and tactile sensibility of dental implants. This review presents the histological, neurophysiological, and psychophysical evidence of osseoperception and also the role of mechanoreceptors in osseoperception. RESULTS The literature on osseoperception in dental implants is very scarce. The initial literature search resulted in 90 articles, of which 81 articles that fulfilled the inclusion criteria were included in this systematic review. CONCLUSION Patients restored with implant-supported prostheses reported improved tactile and motor function when compared with patients wearing complete dentures.

[1]  P. Gong,et al.  A novel bionic design of dental implant for promoting its long-term success using nerve growth factor (NGF): Utilizing nano-springs to construct a stress-cushioning structure inside the implant , 2012, Medical science monitor : international medical journal of experimental and clinical research.

[2]  R. Mericske-Stern,et al.  Tactile Sensibility of Single-Tooth Implants and Natural Teeth Under Local Anesthesia of the Natural Antagonistic Teethcid_252 , 2012 .

[3]  C. Grandin,et al.  Brain plasticity and cortical correlates of osseoperception revealed by punctate mechanical stimulation of osseointegrated oral implants during fMRI. , 2012, European journal of oral implantology.

[4]  R. Jacobs,et al.  Perceptual changes in the peri-implant soft tissues assessed by directional cutaneous kinaesthesia and graphaesthesia: a prospective study. , 2011, Clinical implant dentistry and related research.

[5]  N. Enkling,et al.  Osseoperception: active tactile sensibility of osseointegrated dental implants. , 2010, The International journal of oral & maxillofacial implants.

[6]  R. Mericske-Stern,et al.  Investigating interocclusal perception in tactile teeth sensibility using symmetric and asymmetric analysis , 2010, Clinical Oral Investigations.

[7]  Ye Lin,et al.  [An animal study of peripheral neurophysiologic mechanism in osseoperception phenomena of dental implant]. , 2009, Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology.

[8]  Chen Yan,et al.  Neuroplasticity of edentulous patients with implant-supported full dentures. , 2008, European journal of oral sciences.

[9]  J. Soares,et al.  Progressive recovery of osseoperception as a function of the combination of implant-supported prostheses. , 2008, Clinical oral implants research.

[10]  R. Mericske-Stern,et al.  Tactile sensibility of single-tooth implants and natural teeth. , 2007, Clinical oral implants research.

[11]  Anders Björkman,et al.  Cortical sensory and motor response in a patient whose hand has been replanted: One-year follow up with functional magnetic resonance imaging , 2007, Scandinavian journal of plastic and reconstructive surgery and hand surgery.

[12]  G. Lundborg,et al.  Cortical reintegration of a replanted hand and an osseointegrated thumb prosthesis. , 2007, Acta neurochirurgica. Supplement.

[13]  F. Lobbezoo,et al.  Bruxism: its multiple causes and its effects on dental implants - an updated review. , 2006, Journal of oral rehabilitation.

[14]  R. Jacobs,et al.  From osseoperception to implant-mediated sensory-motor interactions and related clinical implications. , 2006, Journal of oral rehabilitation.

[15]  R. Jacobs,et al.  The neurophysiology of osseointegrated oral implants. A clinically underestimated aspect. , 2006, Journal of oral rehabilitation.

[16]  Anders Björkman,et al.  Functional magnetic resonance imaging shows cortical activation on sensory stimulation of an osseointegrated prosthetic thumb , 2006, Scandinavian journal of plastic and reconstructive surgery and hand surgery.

[17]  S. Huffel,et al.  Detection and multichannel SVD-based filtering of trigeminal somatosensory evoked potentials , 2000, Medical and Biological Engineering and Computing.

[18]  Yuta Suzuki,et al.  Characterization of the peri-implant epithelium in hamster palatine mucosa: behavior of Merkel cells and nerve endings. , 2005, Biomedical research.

[19]  A. Barrett,et al.  An immunohistochemical analysis of human Merkel cell density in gingival epithelium from dentate and edentulous subjects. , 2005, Archives of oral biology.

[20]  J. Ricci,et al.  Partial generation of periodontal ligament on endosseous dental implants in dogs. , 2005, Clinical oral implants research.

[21]  N. Lang,et al.  New formation of periodontal tissues around titanium implants in a novel dentin chamber model. , 2005, Clinical oral implants research.

[22]  P. Marasco,et al.  Plasticity of the cortical dentition representation after tooth extraction in naked mole‐rats , 2005, The Journal of comparative neurology.

[23]  Vaughan G Macefield,et al.  Physiological characteristics of low‐threshold mechanoreceptors in joints, muscle and skin in human subjects , 2005, Clinical and experimental pharmacology & physiology.

[24]  Jye-Chang Lee,et al.  Properties and plasticity of the primate somatosensory and motor cortex related to orofacial sensorimotor function , 2005, Clinical and experimental pharmacology & physiology.

[25]  M. Trulsson.  Sensory and motor function of teeth and dental implants: A basis for osseoperception , 2005, Clinical and experimental pharmacology & physiology.

[26]  D. Mahns,et al.  MECHANOSENSORY PERCEPTION: ARE THERE CONTRIBUTIONS FROM BONE‐ASSOCIATED RECEPTORS? , 2005, Clinical and experimental pharmacology & physiology.

[27]  V. Macefield,et al.  A consensus statement on osseoperception , 2005, Clinical and experimental pharmacology & physiology.

[28]  P. Fugazzotto,et al.  Success and failure rates of osseointegrated implants in function in regenerated bone for 72 to 133 months. , 2005, The International journal of oral & maxillofacial implants.

[29]  N. Fujii,et al.  Regeneration of nerve fibres in the peri-implant epithelium incident to implantation in the rat maxilla as demonstrated by immunocytochemistry for protein gene product 9.5 (PGP9.5) and calcitonin gene-related peptide (CGRP). , 2003, Clinical oral implants research.

[30]  M. Gilthorpe,et al.  Changes in passive tactile sensibility associated with dental implants following their placement. , 2003, The International journal of oral & maxillofacial implants.

[31]  A. Cornaglia,et al.  Microscopic, immunocytochemical, and ultrastructural properties of peri-implant mucosa in humans. , 2002, Journal of periodontology.

[32]  P Schärer,et al.  Immediate occlusal loading of Brånemark implants applied in various jawbone regions: a prospective, 1-year clinical study. , 2001, Clinical implant dentistry and related research.

[33]  R. Jacobs,et al.  Perceptual changes in the anterior maxilla after placement of endosseous implants. , 2001, Clinical implant dentistry and related research.

[34]  S. Wada,et al.  Effect of loading on the development of nerve fibers around oral implants in the dog mandible. , 2001, Clinical oral implants research.

[35]  K. Olmarker,et al.  Intramedullary osseointegration: development of a rodent model and study of histology and neuropeptide changes around titanium implants. , 2001, Journal of rehabilitation research and development.

[36]  S. Van Huffel,et al.  Sensations and trigeminal somatosensory-evoked potentials elicited by electrical stimulation of endosseous oral implants in humans. , 2000, Archives of oral biology.

[37]  Daniel van Steenberghe,et al.  From osseointegration to osseoperception. , 2000 .

[38]  D. van Steenberghe,et al.  From Osseointegration to Osseoperception , 2000, Journal of dentistry research.

[39]  R. Jacobs,et al.  Evaluation of the psychophysical detection threshold level for vibrotactile and pressure stimulation of prosthetic limbs using bone anchorage or soft tissue support , 2000, Prosthetics and orthotics international.

[40]  B. Choi.  Periodontal ligament formation around titanium implants using cultured periodontal ligament cells: a pilot study. , 2000, The International journal of oral & maxillofacial implants.

[41]  E. Ringelstein,et al.  Neuronale Plastizität am Beispiel des somatosensorischen Systems , 1999, Der Nervenarzt.

[42]  I Klineberg,et al.  Osseoperception: Sensory Function and Proprioception , 1999, Advances in dental research.

[43]  E. Ringelstein,et al.  [Neuronal plasticity exemplified by the somatosensory system]. , 1999, Der Nervenarzt.

[44]  I. Lambrichts.  Histological and ultrastructural aspects of bone innervation , 1998 .

[45]  R. Jacobs.  Neurological versus psychophysical assessment of osseoperception , 1998 .

[46]  S. Santavirta,et al.  Efferent Targets of Osseous CGRP‐Immunoreactive Nerve Fiber Before and After Bone Destruction in Adjuvant Arthritic Rat: An Ultramorphological Study on Their Terminal‐Target Relations , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[47]  T. Kondo,et al.  Immunocytochemical study of nerve fibers containing substance P in the junctional epithelium of rats. , 1996, Journal of periodontal research.

[48]  N. Lang,et al.  Thresholds for tactile sensitivity perceived with dental implants remain unchanged during a healing phase of 3 months. , 1996, Clinical oral implants research.

[49]  R. Mericske-Stern,et al.  Occlusal force and oral tactile sensibility measured in partially edentulous patients with ITI implants. , 1996, The International journal of oral & maxillofacial implants.

[50]  A. Lussi,et al.  Threshold of tactile sensitivity perceived with dental endosseous implants and natural teeth. , 1995, Clinical oral implants research.

[51]  R. Jacobs,et al.  Qualitative evaluation of the masseteric poststimulus EMG complex following mechanical or acoustic stimulation of osseointegrated oral implants. , 1995, The International journal of oral & maxillofacial implants.

[52]  W. Schulte.  Implants and the periodontium. , 1995, International dental journal.

[53]  R. Jacobs,et al.  Role of periodontal ligament receptors in the tactile function of teeth: a review. , 1994, Journal of periodontal research.

[54]  T. Takata,et al.  New periodontal ligament formation on a synthetic hydroxyapatite surface. , 1993, Clinical oral implants research.

[55]  D van Steenberghe,et al.  Role of periodontal mechanoreceptors in evoking reflexes in the jaw‐closing muscles of the cat. , 1993, The Journal of physiology.

[56]  E. Chudler,et al.  Static and dynamic responses of periodontal ligament mechanoreceptors and intradental mechanoreceptors. , 1993, Journal of neurophysiology.

[57]  W. Schady,et al.  Changes in sensation after nerve injury or amputation: the role of central factors. , 1993, Journal of neurology, neurosurgery, and psychiatry.

[58]  K Gotfredsen,et al.  Periodontal ligament formation around different types of dental titanium implants. I. The self-tapping screw type implant system. , 1993, Journal of periodontology.

[59]  R. Jacobs,et al.  Comparison between implant-supported prostheses and teeth regarding passive threshold level. , 1993, The International journal of oral & maxillofacial implants.

[60]  A H Geering,et al.  In vivo measurements of maximal occlusal force and minimal pressure threshold on overdentures supported by implants or natural roots: a comparative study, Part 1. , 1993, The International journal of oral & maxillofacial implants.

[61]  R Letz,et al.  Vibrotactile threshold testing in occupational health: a review of current issues and limitations. , 1993, Environmental research.

[62]  R. Jacobs,et al.  Influence of temperature and foil hardness on interocclusal tactile threshold. , 1992, Journal of periodontal research.

[63]  D. Steenberghe,et al.  Morphology of neural endings in the human periodontal ligament: an electron microscopic study. , 1992, Journal of periodontal research.

[64]  T. Taylor.  Fixed implant rehabilitation for the edentulous maxilla. , 1992, The International journal of oral & maxillofacial implants.

[65]  D. Burchfield.  Titanium implants with a true periodontal ligament: An alternative to osseointegrated implants? , 1991 .

[66]  R Jacobs,et al.  Comparative evaluation of the oral tactile function by means of teeth or implant-supported prostheses. , 1991, Clinical oral implants research.

[67]  R. Linden,et al.  The effect of tooth extraction on periodontal ligament mechanoreceptors represented in the mesencephalic nucleus of the cat. , 1989, Archives of oral biology.

[68]  L. Mühlbradt,et al.  Mechanoperception of natural teeth versus endosseous implants revealed by magnitude estimation. , 1989, The International journal of oral & maxillofacial implants.

[69]  P. Ngan,et al.  Neurotransmitters, cytokines, and the control of alveolar bone remodeling in orthodontics. , 1988, Dental clinics of North America.

[70]  M. Schultzberg,et al.  Substance P- and CGRP-immunoreactive nerves in bone , 1988, Peptides.

[71]  T. Haraldson,et al.  Occlusal perception of thickness in patients with bridges on osseointegrated oral implants. , 1984, Scandinavian journal of dental research.

[72]  R Skalak,et al.  Biomechanical considerations in osseointegrated prostheses. , 1983, The Journal of prosthetic dentistry.

[73]  M. B. Bender,et al.  Agraphesthesia A disorder of directional cutaneous kinesthesia or a disorientation in cutaneous space , 1982, Journal of the Neurological Sciences.

[74]  T. Haraldson,et al.  Functional evaluation of bridges on osseointegrated implants in the edentulous jaw , 1979 .

[75]  D. McCloskey.  Kinesthetic sensibility. , 1978, Physiological reviews.

[76]  R. Winkelmann,et al.  Comparison of Nerve Endings in Normal Gingiva with Those in Mucosa Covering Edentulous Alveolar Ridges , 1971, Journal of dental research.

[77]  Malcolm R. Miller,et al.  Observations on the innervation of human long bones , 1963 .