The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

[1]  J. Iredale.  Faculty of 1000 evaluation for Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice. , 2013 .

[2]  M. Barbacid,et al.  What we have learned about pancreatic cancer from mouse models. , 2012, Gastroenterology.

[3]  Zhe Zhang,et al.  Frequent detection of pancreatic lesions in asymptomatic high-risk individuals. , 2012, Gastroenterology.

[4]  H. Friess,et al.  The impact of the activated stroma on pancreatic ductal adenocarcinoma biology and therapy resistance. , 2012, Current molecular medicine.

[5]  M. Apte,et al.  Dangerous liaisons: Pancreatic stellate cells and pancreatic cancer cells , 2012, Journal of gastroenterology and hepatology.

[6]  K. Khanna,et al.  Tocotrienol as a potential anticancer agent. , 2012, Carcinogenesis.

[7]  E. Basch,et al.  Does health-related quality of life improve for advanced pancreatic cancer patients who respond to gemcitabine? Analysis of a randomized phase III trial of the cancer and leukemia group B (CALGB 80303). , 2012, Journal of pain and symptom management.

[8]  H. Friess,et al.  Comparison of 3′-deoxy-3′-[18F]fluorothymidine positron emission tomography (FLT PET) and FDG PET/CT for the detection and characterization of pancreatic tumours , 2012, European Journal of Nuclear Medicine and Molecular Imaging.

[9]  H. Höfler,et al.  Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues , 2012, The Journal of pathology.

[10]  Takehiko Koji,et al.  Epigallocatechin gallate suppresses peritoneal fibrosis in mice. , 2012, Chemico-biological interactions.

[11]  Ho Jin Sung,et al.  An RNA aptamer that specifically binds pancreatic adenocarcinoma up-regulated factor inhibits migration and growth of pancreatic cancer cells. , 2011, Cancer letters.

[12]  J. Willmann,et al.  Pharmacokinetically Stabilized Cystine Knot Peptides That Bind Alpha-v-Beta-6 Integrin with Single-Digit Nanomolar Affinities for Detection of Pancreatic Cancer , 2011, Clinical Cancer Research.

[13]  A. Maitra,et al.  Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[14]  H. Friess,et al.  StellaTUM: current consensus and discussion on pancreatic stellate cell research , 2011, Gut.

[15]  C. Tung,et al.  Detection of pancreatic cancer tumours and precursor lesions by cathepsin E activity in mouse models , 2011, Gut.

[16]  Z. Liao,et al.  Comparison of Antioxidative and Antifibrotic Effects of &agr;-Tocopherol With Those of Tocotrienol-Rich Fraction in a Rat Model of Chronic Pancreatitis , 2011, Pancreas.

[17]  H. Höfler,et al.  Tenascin-C Enhances Pancreatic Cancer Cell Growth and Motility and Affects Cell Adhesion through Activation of the Integrin Pathway , 2011, PloS one.

[18]  A. Meining,et al.  In vivo diagnosis of murine pancreatic intraepithelial neoplasia and early-stage pancreatic cancer by molecular imaging , 2011, Proceedings of the National Academy of Sciences.

[19]  K. Rialon,et al.  Aptamers: potential applications to pancreatic cancer therapy. , 2011, Anti-cancer agents in medicinal chemistry.

[20]  L. Delrue,et al.  Assessment of neovascular permeability in a pancreatic tumor model using dynamic contrast-enhanced (DCE) MRI with contrast agents of different molecular weights , 2011, Magnetic Resonance Materials in Physics, Biology and Medicine.

[21]  Pierre Michel,et al.  FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. , 2011, The New England journal of medicine.

[22]  H. Friess,et al.  Pigment Epithelium-Derived Factor Associates With Neuropathy and Fibrosis in Pancreatic Cancer , 2011, The American Journal of Gastroenterology.

[23]  Z. Jakubek,et al.  Single-domain antibody bioconjugated near-IR quantum dots for targeted cellular imaging of pancreatic cancer. , 2011, Journal of nanoscience and nanotechnology.

[24]  Alessandro Daducci,et al.  DCE-MRI using small-molecular and albumin-binding contrast agents in experimental carcinomas with different stromal content. , 2011, European journal of radiology.

[25]  M. Kudo,et al.  Involvement of Angiotensin II and Reactive Oxygen Species in Pancreatic Fibrosis , 2011, Pancreatology.

[26]  H. Friess,et al.  Comparison of diffusion-weighted MR imaging and multidetector-row CT in the detection of liver metastases in patients operated for pancreatic cancer , 2011, Abdominal Imaging.

[27]  Drew A. Torigian,et al.  CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans , 2011, Science.

[28]  R. Hruban,et al.  Cystic precursors to invasive pancreatic cancer , 2011, Nature Reviews Gastroenterology &Hepatology.

[29]  X.L. Lu,et al.  α-Tocopherol Treatment Ameliorates Chronic Pancreatitis in an Experimental Rat Model Induced by Trinitrobenzene Sulfonic Acid , 2011, Pancreatology.

[30]  N. Hosten,et al.  In vivo imaging of pancreatic tumours and liver metastases using 7 Tesla MRI in a murine orthotopic pancreatic cancer model and a liver metastases model , 2011, BMC Cancer.

[31]  M. Mino‐Kenudson,et al.  Plectin-1 as a Novel Biomarker for Pancreatic Cancer , 2010, Clinical Cancer Research.

[32]  D. Kranz.  Faculty Opinions recommendation of Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha. , 2010 .

[33]  James O. Jones,et al.  Suppression of Antitumor Immunity by Stromal Cells Expressing , 2022 .

[34]  A. Biankin,et al.  Tumorigenesis and Neoplastic Progression Role of Pancreatic Stellate Cells in Pancreatic Cancer Metastasis , 2010 .

[35]  M. Hebrok,et al.  KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma , 2010, Nature Reviews Cancer.

[36]  M. Guilhaus,et al.  Pancreatic stellate cells produce acetylcholine and may play a role in pancreatic exocrine secretion , 2010, Proceedings of the National Academy of Sciences.

[37]  H. Friess,et al.  AZGP1 is a tumor suppressor in pancreatic cancer inducing mesenchymal-to-epithelial transdifferentiation by inhibiting TGF-β-mediated ERK signaling , 2010, Oncogene.

[38]  J. Kleeff,et al.  Tumor microenvironment and progression of pancreatic cancer. , 2010, Experimental oncology.

[39]  G. Hostetter,et al.  Identification of novel pancreatic adenocarcinoma cell-surface targets by gene expression profiling and tissue microarray. , 2010, Biochemical pharmacology.

[40]  R. Schilsky,et al.  Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the Cancer and Leukemia Group B (CALGB 80303). , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[41]  B. Neuschwander‐Tetri,et al.  Angiotensin II signaling through the AT1a and AT1b receptors does not have a role in the development of cerulein-induced chronic pancreatitis in the mouse. , 2010, American journal of physiology. Gastrointestinal and liver physiology.

[42]  D. Radisky,et al.  Matrix Metalloproteinase-Induced Epithelial-Mesenchymal Transition in Breast Cancer , 2010, Journal of Mammary Gland Biology and Neoplasia.

[43]  W. Ansorge,et al.  Organ-, inflammation- and cancer specific transcriptional fingerprints of pancreatic and hepatic stellate cells , 2010, Molecular Cancer.

[44]  Z. Werb,et al.  Matrix Metalloproteinases: Regulators of the Tumor Microenvironment , 2010, Cell.

[45]  Patrick Maisonneuve,et al.  Epidemiology of pancreatic cancer: an overview , 2009, Nature Reviews Gastroenterology &Hepatology.

[46]  S. Pandol,et al.  Desmoplasia of pancreatic ductal adenocarcinoma. , 2009, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[47]  M. Clench,et al.  MALDI-ion mobility separation-mass spectrometry imaging of glucose-regulated protein 78 kDa (Grp78) in human formalin-fixed, paraffin-embedded pancreatic adenocarcinoma tissue sections. , 2009, Journal of proteome research.

[48]  David Allard,et al.  Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer , 2009, Science.

[49]  V. Shah,et al.  Interplay of Tumor Microenvironment Cell Types with Parenchymal Cells in Pancreatic Cancer Development and Therapeutic Implications , 2009, Journal of gastrointestinal cancer.

[50]  Helmut Friess,et al.  Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma. , 2009, Neoplasia.

[51]  S. Nie,et al.  Molecular imaging of pancreatic cancer in an animal model using targeted multifunctional nanoparticles. , 2009, Gastroenterology.

[52]  A. Masamune,et al.  Ellagic Acid Inhibits Pancreatic Fibrosis in Male Wistar Bonn/Kobori Rats , 2009, Digestive Diseases and Sciences.

[53]  H. Tian,et al.  Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis , 2009, Proceedings of the National Academy of Sciences.

[54]  Y.-S. Kim,et al.  Formation of vitamin A lipid droplets in pancreatic stellate cells requires albumin , 2009, Gut.

[55]  A. Masamune,et al.  Signal transduction in pancreatic stellate cells , 2009, Journal of Gastroenterology.

[56]  Masahiro Inoue,et al.  Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. , 2009, Cancer cell.

[57]  B. Neuschwander‐Tetri,et al.  Protective role of angiotensin II type 2 receptor signaling in a mouse model of pancreatic fibrosis. , 2009, American journal of physiology. Gastrointestinal and liver physiology.

[58]  H. Friess,et al.  Pancreatic Islet and Stellate Cells Are the Main Sources of Endocrine Gland-Derived Vascular Endothelial Growth Factor/Prokineticin-1 in Pancreatic Cancer , 2008, Pancreatology.

[59]  A. Masamune,et al.  Fibrinogen induces cytokine and collagen production in pancreatic stellate cells , 2008, Gut.

[60]  D. Goldstein,et al.  Pancreatic stellate cells and pancreatic cancer cells: an unholy alliance. , 2008, Cancer research.

[61]  A. Masamune,et al.  Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer. , 2008, American journal of physiology. Gastrointestinal and liver physiology.

[62]  Helmut Friess,et al.  The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma. , 2008, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[63]  H. Friess,et al.  Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma , 2008, Cancer biology & therapy.

[64]  F. Real,et al.  Pancreatic Ductal Adenocarcinoma: Cellular Origin, Signaling Pathways and Stroma Contribution , 2008, Pancreatology.

[65]  S. Lowe,et al.  Senescence of Activated Stellate Cells Limits Liver Fibrosis , 2008, Cell.

[66]  R. Weissleder,et al.  Near infrared fluorescence-based bacteriophage particles for ratiometric pH imaging. , 2008, Bioconjugate chemistry.

[67]  A. Masamune,et al.  Pancreatic stellate cells express Toll-like receptors , 2008, Journal of Gastroenterology.

[68]  M. Fukayama,et al.  Periostin deposition in the stroma of invasive and intraductal neoplasms of the pancreas , 2008, Modern Pathology.

[69]  Hua Tian,et al.  A paracrine requirement for hedgehog signalling in cancer , 2008, Nature.

[70]  D. Radisky,et al.  Matrix metalloproteinase-induced fibrosis and malignancy in breast and lung. , 2008, Proceedings of the American Thoracic Society.

[71]  David Goldstein,et al.  Pancreatic stellate cells: partners in crime with pancreatic cancer cells. , 2008, Cancer research.

[72]  H. Friess,et al.  Cannabinoids Reduce Markers of Inflammation and Fibrosis in Pancreatic Stellate Cells , 2008, PloS one.

[73]  H. Friess,et al.  Activation of Wnt signalling in stroma from pancreatic cancer identified by gene expression profiling , 2008, Journal of cellular and molecular medicine.

[74]  Douglas B. Evans,et al.  Cancer-associated stromal fibroblasts promote pancreatic tumor progression. , 2008, Cancer research.

[75]  H. Friess,et al.  Mononuclear cells modulate the activity of pancreatic stellate cells which in turn promote fibrosis and inflammation in chronic pancreatitis , 2007, Journal of Translational Medicine.

[76]  R. DePinho,et al.  Targeted Nanoparticles for Imaging Incipient Pancreatic Ductal Adenocarcinoma , 2007, PLoS medicine.

[77]  J. Malagelada,et al.  Tocotrienols induce apoptosis and autophagy in rat pancreatic stellate cells through the mitochondrial death pathway. , 2007, Gastroenterology.

[78]  P. Murawa,et al.  Erlotinib Plus Gemcitabine Compared With Gemcitabine Alone in Patients With Advanced Pancreatic Cancer: A Phase III Trial of the National Cancer Institute of Canada Clinical Trials Group , 2023, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[79]  Tomas Mitkus,et al.  Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity. , 2007, Gastroenterology.

[80]  P. Ernsberger,et al.  Metabolic actions of angiotensin receptor antagonists: PPAR-γ agonist actions or a class effect? , 2007 .

[81]  M. Barbacid,et al.  Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. , 2007, Cancer cell.

[82]  E. Krenning,et al.  Novel 111In-labelled bombesin analogues for molecular imaging of prostate tumours , 2007, European Journal of Nuclear Medicine and Molecular Imaging.

[83]  H. Kayed,et al.  Expression of extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) in pancreatic neoplasm and pancreatic stellate cells , 2007 .

[84]  M. Omary,et al.  The pancreatic stellate cell: a star on the rise in pancreatic diseases. , 2007, The Journal of clinical investigation.

[85]  M. R. Kumar,et al.  Simultaneous analysis of ellagic acid and coenzyme Q(10) by derivative spectroscopy and HPLC. , 2006, Talanta.

[86]  J. Cameron,et al.  Multifocal Neoplastic Precursor Lesions Associated With Lobular Atrophy of the Pancreas in Patients Having a Strong Family History of Pancreatic Cancer , 2006, The American journal of surgical pathology.

[87]  M. Loeffler,et al.  Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake. , 2006, The Journal of clinical investigation.

[88]  Martin Paul,et al.  Physiology of local renin-angiotensin systems. , 2006, Physiological reviews.

[89]  Christopher M. Overall,et al.  Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy , 2006, Nature Reviews Cancer.

[90]  Kennichi Satoh,et al.  Ellagic acid blocks activation of pancreatic stellate cells. , 2005, Biochemical pharmacology.

[91]  R. DePinho,et al.  Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. , 2005, Cancer cell.

[92]  A. Buck,et al.  Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. , 2005, Gastroenterology.

[93]  P. Leung,et al.  The role of the pancreatic renin–angiotensin system in acinar digestive enzyme secretion and in acute pancreatitis , 2004, Regulatory Peptides.

[94]  K. Campbell,et al.  Intraductal Papillary Mucinous Neoplasms of the Pancreas: An Updated Experience , 2004, Annals of surgery.

[95]  N. Funel,et al.  Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma , 2004, Journal of Clinical Pathology.

[96]  C. Bassi,et al.  Main-Duct Intraductal Papillary Mucinous Neoplasms of the Pancreas: Clinical Predictors of Malignancy and Long-term Survival Following Resection , 2004, Annals of surgery.

[97]  Alison P. Klein,et al.  Prospective Risk of Pancreatic Cancer in Familial Pancreatic Cancer Kindreds , 2004, Cancer Research.

[98]  P. Leung,et al.  Prophylactic and therapeutic treatments with AT 1 and AT 2 receptor antagonists and their effects on changes in the severity of pancreatitis. , 2004, The international journal of biochemistry & cell biology.

[99]  T. Joh,et al.  Angiotensin-converting enzyme inhibitor attenuates pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori rats. , 2003, Gastroenterology.

[100]  J. Scoazec,et al.  Prognosis of malignant intraductal papillary mucinous tumours of the pancreas after surgical resection. Comparison with pancreatic ductal adenocarcinoma , 2002, Gut.

[101]  Roland L. Dunbrack,et al.  Promotion of tumor growth by murine fibroblast activation protein, a serine protease, in an animal model. , 2002, Cancer research.

[102]  S. Kumar,et al.  Free radical studies of ellagic acid, a natural phenolic antioxidant. , 2002, Journal of agricultural and food chemistry.

[103]  K. Takeuchi,et al.  Effect of ellagic acid on gastric damage induced in ischemic rat stomachs following ammonia or reperfusion. , 2002, Life sciences.

[104]  R. Knuechel,et al.  A heterologous 3-D coculture model of breast tumor cells and fibroblasts to study tumor-associated fibroblast differentiation. , 2001, Experimental cell research.

[105]  K. Pfizenmaier,et al.  Human antibody derivatives against the fibroblast activation protein for tumor stroma targeting of carcinomas , 2001, International journal of cancer.

[106]  T. Mattfeldt,et al.  A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease. , 2001, Genes & development.

[107]  S. Goodman,et al.  Very high risk of cancer in familial Peutz-Jeghers syndrome. , 2000, Gastroenterology.

[108]  M. Barcellos-Hoff,et al.  Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells. , 2000, Cancer research.

[109]  D. Pinkel,et al.  The Stromal Proteinase MMP3/Stromelysin-1 Promotes Mammary Carcinogenesis , 1999, Cell.

[110]  R. Schmid,et al.  Identification, culture, and characterization of pancreatic stellate cells in rats and humans. , 1998, Gastroenterology.

[111]  M. Korsten,et al.  Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture , 1998, Gut.

[112]  T. Suzuki,et al.  The prognosis of intraductal papillary mucinous tumors of the pancreas. , 1998, Hepato-gastroenterology.

[113]  R. Kuttan,et al.  Inhibition of liver fibrosis by ellagic acid. , 1996, Indian journal of physiology and pharmacology.

[114]  H. Thaler,et al.  Pain and depression in patients with newly diagnosed pancreas cancer. , 1995, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[115]  J K McLaughlin,et al.  Pancreatitis and the risk of pancreatic cancer. , 1993, The New England journal of medicine.

[116]  H. Kern,et al.  Distribution of Extracellular Matrix Proteins in Pancreatic Ductal Adenocarcinoma and Its Influence on Tumor Cell Proliferation in Vitro , 1987, Pancreas.

[117]  Christopher G. Langton,et al.  Studying artificial life with cellular automata , 1986 .

[118]  S Marsoni,et al.  The phase II trial. , 1985, Cancer treatment reports.

[119]  P. Pour.  Islet cells as a component of pancreatic ductal neoplasms. I. Experimental study: ductular cells, including islet cell precursors, as primary progenitor cells of tumors. , 1978, The American journal of pathology.

[120]  M. Peach.  Renin-angiotensin system: biochemistry and mechanisms of action. , 1977, Physiological reviews.

[121]  S. Oparil,et al.  The renin-angiotensin system (second of two parts). , 1974, The New England journal of medicine.

[122]  S. Oparil,et al.  The renin-angiotensin system (first of two parts). , 1974, The New England journal of medicine.

[123]  E. Eichler,et al.  Evolutionary-new centromeres preferentially emerge within gene deserts , 2008, Genome Biology.

[124]  Laura H. Tang,et al.  Survival after Resection of Pancreatic Adenocarcinoma: Results from a Single Institution over Three Decades , 2011, Annals of Surgical Oncology.

[125]  T. Conroy,et al.  Metastatic pancreatic cancer: old drugs, new paradigms , 2011, Current opinion in oncology.

[126]  Michael Goggins,et al.  Update on pancreatic intraepithelial neoplasia. , 2008, International journal of clinical and experimental pathology.

[127]  A. Masamune,et al.  NADPH oxidase plays a crucial role in the activation of pancreatic stellate cells. , 2008, American journal of physiology. Gastrointestinal and liver physiology.

[128]  P. Ernsberger,et al.  Metabolic actions of angiotensin receptor antagonists: PPAR-gamma agonist actions or a class effect? , 2007, Current opinion in pharmacology.

[129]  A. Jemal,et al.  Global cancer statistics , 2011, CA: a cancer journal for clinicians.