Reproducibility of dynamic contrast-enhanced MR imaging: why we should care.

The results of two studies published in this issue of Radiology stress the difficulties of performing dynamic contrast-enhanced MR imaging across different commercially available software platforms in clinical practice, but more important suggest a potential solution.

[1]  D. Collins,et al.  Advanced solid tumors treated with cediranib: comparison of dynamic contrast-enhanced MR imaging and CT as markers of vascular activity. , 2012, Radiology.

[2]  Steve Halligan,et al.  Quantitative assessment of colorectal cancer tumor vascular parameters by using perfusion CT: influence of tumor region of interest. , 2008, Radiology.

[3]  H. Huisman,et al.  Imaging vascular function for early stage clinical trials using dynamic contrast-enhanced magnetic resonance imaging , 2012, European Radiology.

[4]  Steven R. Breault,et al.  Reproducibility of dynamic contrast-enhanced MR imaging. Part II. Comparison of intra- and interobserver variability with manual region of interest placement versus semiautomatic lesion segmentation and histogram analysis. , 2013, Radiology.

[5]  A. Harris,et al.  Phase I Trial of Combretastatin A4 Phosphate (CA4P) in Combination with Bevacizumab in Patients with Advanced Cancer , 2012, Clinical Cancer Research.

[6]  Daniel Balvay,et al.  Reproducibility of dynamic contrast-enhanced MR imaging. , 2013, Radiology.

[7]  J R Griffiths,et al.  Clinical studies. , 2005, Advances in pharmacology.

[8]  Matthew S Davenport,et al.  Reproducibility of dynamic contrast-enhanced MR imaging. Part I. Perfusion characteristics in the female pelvis by using multiple computer-aided diagnosis perfusion analysis solutions. , 2013, Radiology.

[9]  Steve Halligan,et al.  Quantitative tumor perfusion assessment with multidetector CT: are measurements from two commercial software packages interchangeable? , 2007, Radiology.

[10]  M. P. Hayball,et al.  Current status and guidelines for the assessment of tumour vascular support with dynamic contrast-enhanced computed tomography , 2012, European Radiology.