Umbilical Cord Perivascular Cells: A Mesenchymal Cell Source for Treatment of Tendon and Ligament Injuries

We investigated the capacity of human umbilical cord perivascular cells (HUCPVCs)to repair tendon damage in a collagenase tendon injury model in rats. Our hypothesis wasthat HUCPVCs would be able to produce an organized extracellular matrix and facilitatetissue regeneration in this rat model. HUCPVCs were injected, in collagenase, into theAchilles tendon of nude rats. Harvested tendons showed the presence of HUCPVCs at thesite of injury, whose morphology changed from rounded to elongated over the post-injurytime of 30 days. Human genes for collagen type 1 and -actin were expressed at all timepoints and there was also a signi cant increase in the tensile strength and sti ness valuesat 30 day post-injury in the experimental group. We conclude that HUCPVCs facilitatedregeneration in our model, and thus may be a putative cell source for the treatment oftendon and ligament injuries.

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