Quality of life measures in lung cancer.

Lung cancer is one of the leading causes of cancer death worldwide. Survival has not improved significantly in spite of newer therapies. In view of the high-symptom burden and severe morbidity, evaluation of quality of life (QOL) becomes important in these patients. Several instruments are now available for this purpose, and have demonstrated good correlation with performance status, symptoms, and survival. Quality of life assessments also help in comparing different therapeutic regimes, thus allowing selection of the appropriate modality. Problems of inconsistent interpretability and high-patient dropout rate poses a challenging problem that needs to be tackled. In spite of these drawbacks, QOL is now considered to be an essential component of lung cancer management and should be performed routinely. Such a practice will help the physician plan appropriate treatment strategies and set practical therapeutic goals.

[1]  R Milroy,et al.  Quality of life: perception of lung cancer patients. , 1996, European journal of cancer.

[2]  B. Bergman,et al.  Quality of life and survival in patients with advanced non-small cell lung cancer receiving supportive care plus chemotherapy with carboplatin and etoposide or supportive care only. A multicentre randomised phase III trial. Joint Lung Cancer Study Group. , 1998, European journal of cancer.

[3]  Ali Montazeri,et al.  Quality of life in lung cancer patients: as an important prognostic factor. , 2001, Lung cancer.

[4]  D. Karnofsky The clinical evaluation of chemotherapeutic agents in cancer , 1949 .

[5]  Arto Ohinmaa,et al.  Nottingham Health Profilen (NHP) suomalainen versio , 1995 .

[6]  M. Ranson,et al.  Randomized trial of paclitaxel plus supportive care versus supportive care for patients with advanced non-small-cell lung cancer. , 2000, Journal of the National Cancer Institute.

[7]  D. Geddes Quality of life in lung cancer. , 1991, Respiratory medicine.

[8]  D. Osoba,et al.  The Karnofsky performance status scale re-examined: a cross-validation with the EORTC-C30 , 1994, Quality of Life Research.

[9]  M. Kris,et al.  Quality of life during clinical trials: conceptual model for the Lung Cancer Symptom Scale (LCSS) , 1994, Supportive Care in Cancer.

[10]  J. Jett,et al.  Quality of life in 650 lung cancer survivors 6 months to 4 years after diagnosis. , 2004, Mayo Clinic proceedings.

[11]  Emil Frei,et al.  Appraisal of methods for the study of chemotherapy of cancer in man: Comparative therapeutic trial of nitrogen mustard and triethylene thiophosphoramide , 1960 .

[12]  T. Hickish,et al.  Duration of chemotherapy in advanced non-small-cell lung cancer: a randomized trial of three versus six courses of mitomycin, vinblastine, and cisplatin. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[13]  J. Ferlay,et al.  Globocan 2000 : cancer incidence, mortality and prevalence worldwide , 2001 .

[14]  L. Sarna,et al.  Assessment of quality of life and symptom improvement in lung cancer clinical trials. , 2004, Seminars in oncology.

[15]  R. Gralla,et al.  Comparison of instruments for measuring quality of life in patients with lung cancer. , 1996, Seminars in oncology.

[16]  M. Paesmans,et al.  Response to chemotherapy, quality of life benefits and survival in advanced non-small cell lung cancer: review of literature results. , 2001, Lung cancer.

[17]  A. Gift Clinical measurement of dyspnea. , 1989, Dimensions of critical care nursing : DCCN.

[18]  J. Bogaerts,et al.  Phase III comparative study of high-dose cisplatin versus a combination of paclitaxel and cisplatin in patients with advanced non-small-cell lung cancer. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[19]  P. Ganz,et al.  Quality of life assessment. An independent prognostic variable for survival in lung cancer , 1991, Cancer.

[20]  M. Cooley,et al.  Symptoms in adults with lung cancer. A systematic research review. , 2000, Journal of pain and symptom management.

[21]  S. Kaasa,et al.  The EORTC QLQ-LC13: a modular supplement to the EORTC Core Quality of Life Questionnaire (QLQ-C30) for use in lung cancer clinical trials. EORTC Study Group on Quality of Life. , 1994, European journal of cancer.

[22]  Aninda Mandal,et al.  REVIEW OF LITERATURE REVIEW OF LITERATURE , 2005 .

[23]  G. Luporini,et al.  Effects of vinorelbine on quality of life and survival of elderly patients with advanced non-small-cell lung cancer. The Elderly Lung Cancer Vinorelbine Italian Study Group. , 1999, Journal of the National Cancer Institute.

[24]  R. Stephens,et al.  Symptoms at presentation for treatment in patients with lung cancer: implications for the evaluation of palliative treatment. The Medical Research Council (MRC) Lung Cancer Working Party. , 1995, British Journal of Cancer.

[25]  M. Jiroutek,et al.  Comparison of survival and quality of life in advanced non-small-cell lung cancer patients treated with two dose levels of paclitaxel combined with cisplatin versus etoposide with cisplatin: results of an Eastern Cooperative Oncology Group trial. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[26]  R. Feld Endpoints in cancer clinical trials: is there a need for measuring quality of life? , 2004, Supportive Care in Cancer.

[27]  D. Tulsky,et al.  Quality of life in cancer: definition, purpose, and method of measurement. , 1993, Cancer investigation.

[28]  P. Ganz,et al.  Quality of life in adult survivors of lung, colon and prostate cancer , 1994, Quality of Life Research.

[29]  J. Holland,et al.  Is quality of life predictive of the survival of patients with advanced nonsmall cell lung carcinoma? , 1999, Cancer.

[30]  D. Osoba,et al.  The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. , 1993, Journal of the National Cancer Institute.

[31]  M. Kris,et al.  Normative data and trends in quality of life from the Lung Cancer Symptom Scale (LCSS) , 1999, Supportive Care in Cancer.

[32]  F. Roila,et al.  Quality of life as a primary end point in oncology. , 2001, Annals of Oncology.

[33]  A. Carrato,et al.  Randomized phase III study of gemcitabine-cisplatin versus etoposide-cisplatin in the treatment of locally advanced or metastatic non-small-cell lung cancer. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[34]  P M Fayers,et al.  Measuring and analysing quality of life in cancer clinical trials: a review. , 1983, Statistics in medicine.

[35]  S. Barni,et al.  Gemcitabine and cisplatin versus mitomycin, ifosfamide, and cisplatin in advanced non-small-cell lung cancer: A randomized phase III study of the Italian Lung Cancer Project. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[36]  V. Lorusso,et al.  Gemcitabine plus vinorelbine versus vinorelbine alone in elderly patients with advanced non-small-cell lung cancer. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[37]  A. Bond,et al.  The use of analogue scales in rating subjective feelings , 1974 .

[38]  S. Piantadosi,et al.  Quality of life in lung cancer surgical adjuvant trials. , 1994, Chest.

[39]  D. Ferrigno,et al.  Prognostic factors in lung cancer: tables and comments. , 1994, The European respiratory journal.

[40]  D. Cella,et al.  What is a clinically meaningful change on the Functional Assessment of Cancer Therapy-Lung (FACT-L) Questionnaire? Results from Eastern Cooperative Oncology Group (ECOG) Study 5592. , 2002, Journal of clinical epidemiology.

[41]  D. Tulsky,et al.  Reliability and validity of the Functional Assessment of Cancer Therapy-Lung (FACT-L) quality of life instrument. , 1995, Lung cancer.

[42]  N. Aaronson,et al.  The prognostic impact of quality of life assessed with the EORTC QLQ-C30 in inoperable non-small cell lung carcinoma treated with radiotherapy. , 2000, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[43]  C. Gridelli,et al.  Quality of life in lung cancer patients. , 2001, Annals of oncology : official journal of the European Society for Medical Oncology.

[44]  Ali Montazeri,et al.  Quality of life in patients with lung cancer: a review of literature from 1970 to 1995. , 1998, Chest.