Nanotecnologie: una grande rivoluzione che parte dal piccolo

Nanotechnology: a big revolution from the small world AbstrAct: Nanotechnology is a multidisciplinary field originating from the interaction of several dif- ferent disciplines, such as engineering, physics, biology and chemistry. New materials and devices effectively interact with the body at molecular level, yielding a brand new range of highly selective and targeted applications designed to maximize the therapeutic efficiency while reducing the side effects. Liposomes, quantum dots, carbon nanotubes and superparamagnetic nanoparticles are among the most assessed nanotechnologies. Meanwhile, other futuristic platforms are paving the way toward a new scientific paradigm, able to deeply change the research path in the medical science. The growth of nanotechnology, driven by the dramatic advances in science and technology, clearly cre- ates new opportunities for the development of the medical science and disease treatment in hu- man health care. Despite the concerns and the on-going studies about their safety, nanotechnology clearly emerges as holding the promise of delivering one of the greatest breakthroughs in the history of medical science.

[1]  M. Manyak,et al.  The evolution of imaging in advanced prostate cancer. , 2006, The Urologic clinics of North America.

[2]  M. Bruchez,et al.  Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots , 2003, Nature Biotechnology.

[3]  Xun Sun,et al.  The use of PEGylated liposomes to prolong the circulation lifetime of salvianolic acid B. , 2012, Fitoterapia.

[4]  Si-Shen Feng,et al.  Vitamin E TPGS coated liposomes enhanced cellular uptake and cytotoxicity of docetaxel in brain cancer cells. , 2011, International journal of pharmaceutics.

[5]  Bradley D Anderson,et al.  Enhanced active liposomal loading of a poorly soluble ionizable drug using supersaturated drug solutions. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[6]  Byron Ballou,et al.  Fluorescence imaging of tumors in vivo. , 2005, Current medicinal chemistry.

[7]  Yun Chen,et al.  Quantum dots for labeling live cells. , 2012, Methods in molecular biology.

[8]  R K Jain,et al.  Transport of molecules, particles, and cells in solid tumors. , 1999, Annual review of biomedical engineering.

[9]  Ze Lu,et al.  Paclitaxel-Loaded Gelatin Nanoparticles for Intravesical Bladder Cancer Therapy , 2004, Clinical Cancer Research.

[10]  S. Nie,et al.  In vivo cancer targeting and imaging with semiconductor quantum dots , 2004, Nature Biotechnology.

[11]  Andrea Bevilacqua,et al.  Integrated SFCW Transceivers for UWB Breast Cancer Imaging: Architectures and Circuit Constraints , 2012, IEEE Transactions on Circuits and Systems I: Regular Papers.

[12]  Ning Wang,et al.  Nanoneedle: a multifunctional tool for biological studies in living cells. , 2010, Nanoscale.

[13]  Maurizio Prato,et al.  Functionalized Carbon Nanotubes in Drug Design and Discovery , 2008 .

[14]  Deng-Guang Yu,et al.  Liposomes self-assembled from electrosprayed composite microparticles , 2012, Nanotechnology.

[15]  David Kleinfeld,et al.  In vivo manipulation of biological systems with femtosecond laser pulses , 2006, SPIE High-Power Laser Ablation.

[16]  Jörg Huwyler,et al.  Transferrin-conjugated liposome targeting of photosensitizer AlPcS4 to rat bladder carcinoma cells. , 2004, Journal of the National Cancer Institute.

[17]  H. Dai,et al.  Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[18]  M. Radomski,et al.  Nanoparticles: pharmacological and toxicological significance , 2007, British journal of pharmacology.

[19]  Wole Soboyejo,et al.  The Use of Ligand Conjugated Superparamagnetic Iron Oxide Nanoparticles (SPION) for Early Detection of Metastases , 2005 .

[20]  Russell J Mumper,et al.  Microparticles and nanoparticles as delivery systems for DNA vaccines. , 2003, Critical reviews in therapeutic drug carrier systems.

[21]  S. Iyuke,et al.  Nanoparticles toxicity and their routes of exposures. , 2012, Pakistan journal of pharmaceutical sciences.

[22]  Willis,et al.  Ligand-targeted liposomes. , 1998, Advanced drug delivery reviews.

[23]  C R Wirtz,et al.  Monocrystalline iron oxide nanoparticles: possible solution to the problem of surgically induced intracranial contrast enhancement in intraoperative MR imaging. , 2001, AJNR. American journal of neuroradiology.

[24]  R. Reilly.  Carbon Nanotubes: Potential Benefits and Risks of Nanotechnology in Nuclear Medicine , 2007, Journal of Nuclear Medicine.

[25]  Yan Zhang,et al.  Protease-modulated cellular uptake of quantum dots. , 2006, Nano letters.

[26]  D. Crommelin,et al.  A new application for liposomes in cancer therapy , 1993, FEBS letters.

[27]  Sanjiv S Gambhir,et al.  Self-illuminating quantum dot conjugates for in vivo imaging , 2006, Nature Biotechnology.

[28]  Matteo Pasquali,et al.  Carbon nanotube‐enhanced thermal destruction of cancer cells in a noninvasive radiofrequency field , 2007, Cancer.

[29]  Marilena Loizidou,et al.  Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer. , 2009, Trends in pharmacological sciences.

[30]  Rinti Banerjee,et al.  Nanostructured self assembled lipid materials for drug delivery and tissue engineering. , 2011, Therapeutic delivery.

[31]  Wolfgang J. Parak,et al.  Quantum Dot-Based Cell Motility Assay , 2005, Science's STKE.

[32]  S. Nie,et al.  Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy , 2008, International journal of nanomedicine.

[33]  Alexander M. Seifalian,et al.  Clinical Potential of Quantum Dots , 2008, Journal of biomedicine & biotechnology.

[34]  G. Gregoriadis,et al.  Fate of protein-containing liposomes injected into rats. An approach to the treatment of storage diseases. , 1972, European journal of biochemistry.

[35]  L. Mazzola,et al.  Commercializing nanotechnology , 2003, Nature Biotechnology.

[36]  A Cuschieri,et al.  Cell Creeping and Controlled Migration by Magnetic Carbon Nanotubes , 2009, Nanoscale research letters.

[37]  J. Finkelstein,et al.  Translocation of Inhaled Ultrafine Manganese Oxide Particles to the Central Nervous System , 2006, Environmental health perspectives.

[38]  Feng Zhao,et al.  Acute toxicological effects of copper nanoparticles in vivo. , 2006, Toxicology letters.

[39]  M. Meyyappan,et al.  U-Health Smart Home , 2011, IEEE Nanotechnology Magazine.

[40]  A. Jordan,et al.  Clinical applications of magnetic nanoparticles for hyperthermia , 2008, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[41]  Yuan Zhang,et al.  Delivery of Telomerase Reverse Transcriptase Small Interfering RNA in Complex with Positively Charged Single-Walled Carbon Nanotubes Suppresses Tumor Growth , 2006, Clinical Cancer Research.

[42]  S. Doak,et al.  NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. , 2009, Biomaterials.

[43]  O. Kayser,et al.  The impact of nanobiotechnology on the development of new drug delivery systems. , 2005, Current pharmaceutical biotechnology.

[44]  Sarfraz Ahmad,et al.  Use of pegylated liposomal doxorubicin in the management of platinum-sensitive recurrent ovarian cancer: current concepts , 2012, Expert review of anticancer therapy.

[45]  Hak Soo Choi,et al.  Image-Guided Oncologic Surgery Using Invisible Light: Completed Pre-Clinical Development for Sentinel Lymph Node Mapping , 2006, Annals of Surgical Oncology.

[46]  J. James,et al.  Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. , 2003, Toxicological sciences : an official journal of the Society of Toxicology.

[47]  Qiang Wu,et al.  The therapeutic efficacy of CdTe and CdSe quantum dots for photothermal cancer therapy. , 2012, Biomaterials.

[48]  Silvia Muro,et al.  Challenges in design and characterization of ligand-targeted drug delivery systems. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[49]  F. Dosio,et al.  Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential , 2006, International journal of nanomedicine.

[50]  Dmitri Artemov,et al.  MR molecular imaging of the Her‐2/neu receptor in breast cancer cells using targeted iron oxide nanoparticles , 2003, Magnetic resonance in medicine.

[51]  Andrea Bevilacqua,et al.  A 1.75–15 GHz stepped frequency receiver for breast cancer imaging in 65 nm CMOS , 2012, 2012 Proceedings of the ESSCIRC (ESSCIRC).

[52]  Peter Wust,et al.  Thermotherapy of prostate cancer using magnetic nanoparticles: feasibility, imaging, and three-dimensional temperature distribution. , 2007, European urology.

[53]  S. Ferrini,et al.  MR and Iron Magnetic Nanoparticles. Imaging Opportunities in Preclinical and Translational Research , 2008, Tumori.

[54]  Koning,et al.  Immunoliposomes for the targeted delivery of antitumor drugs. , 1999, Advanced drug delivery reviews.

[55]  Hui Xie,et al.  In situ peeling of one-dimensional nanostructures using a dual-probe nanotweezer. , 2010, The Review of scientific instruments.

[56]  G Gregoriadis,et al.  Influence of surface hydrophilicity of liposomes on their interaction with plasma protein and clearance from the circulation: studies with poly(ethylene glycol)-coated vesicles. , 1991, Biochimica et biophysica acta.