Follicular Penetration of Topically Applied Caffeine via a Shampoo Formulation

Aims: Follicular drug delivery is the prerequisite for an effective treatment of androgenetic alopecia or other reasons of premature hair loss. Methods: The follicular penetration of caffeine, applied topically in a shampoo formulation for 2 min, was measured with highly sensitive surface ionization in combination with mass spectroscopy, a selective method for the detection of very small quantities of transcutaneously absorbed substances in the blood. An experimental protocol, developed to selectively block the follicular pathway within the test area, was used. Based on this principle, a clear distinction between interfollicular and follicular penetration of topically applied caffeine was feasible. Results: After 2 min, caffeine penetrated via the hair follicles and stratum corneum. Conclusion: It was found that the penetration via hair follicles was faster and higher compared with the interfollicular route and that hair follicles are the only pathway for fast caffeine absorption during the first 20 min after application.

[1]  W. Sterry,et al.  Follicular Penetration: Development of a Method to Block the Follicles Selectively against the Penetration of Topically Applied Substances , 2006, Skin Pharmacology and Physiology.

[2]  J. Lademann,et al.  Follicular targeting--a promising tool in selective dermatotherapy. , 2005, The journal of investigative dermatology. Symposium proceedings.

[3]  E. Baron,et al.  Protective effects of tea polyphenols and caffeine , 2005, Expert review of anticancer therapy.

[4]  J. Lademann,et al.  Optical investigations to avoid the disturbing influences of furrows and wrinkles quantifying penetration of drugs and cosmetics into the skin by tape stripping. , 2005, Journal of biomedical optics.

[5]  Y. Lou,et al.  Administration of green tea or caffeine enhances the disappearance of UVB-induced patches of mutant p53 positive epidermal cells in SKH-1 mice. , 2005, Carcinogenesis.

[6]  J. Dórea,et al.  Is coffee a functional food? , 2005, British Journal of Nutrition.

[7]  U. Rasulev,et al.  Application of surface ionization methods for highly sensitive and selective analysis of benzodiazepine derivatives. , 2005, Journal of pharmaceutical and biomedical analysis.

[8]  P. Duh,et al.  Antioxidant properties of roasted coffee residues. , 2005, Journal of agricultural and food chemistry.

[9]  J. Lademann,et al.  Cutaneous distribution and localization of dyes affected by vehicles all with different lipophilicity , 2005, Archives of Dermatological Research.

[10]  Y. Lou,et al.  Stimulatory Effect of Topical Application of Caffeine on UVB-Induced Apoptosis in the Epidermis of p53 and Bax Knockout Mice , 2004, Cancer Research.

[11]  W. Sterry,et al.  Variations of hair follicle size and distribution in different body sites. , 2004, The Journal of investigative dermatology.

[12]  G. Lucassen,et al.  Vasoconstrictive effect of topical applied corticosteroids measured by laser doppler imaging and reflectance spectroscopy. , 2003, Microvascular research.

[13]  D. Whiting,et al.  Hair counts from scalp biopsy specimens in Asians. , 2002, Journal of the American Academy of Dermatology.

[14]  E. Benfeldt.  In vivo microdialysis for the investigation of drug levels in the dermis and the effect of barrier perturbation on cutaneous drug penetration. Studies in hairless rats and human subjects. , 1999, Acta dermato-venereologica. Supplementum.

[15]  D A Whiting,et al.  Diagnostic and predictive value of horizontal sections of scalp biopsy specimens in male pattern androgenetic alopecia. , 1993, Journal of the American Academy of Dermatology.

[16]  W. Martin,et al.  Pharmacokinetics and absolute bioavailability of ibuprofen after oral administration of ibuprofen lysine in man. , 1990, Biopharmaceutics & drug disposition.

[17]  Maibach Hi,et al.  Regional variation in percutaneous penetration in man. Pesticides. , 1971 .

[18]  H I Maibach,et al.  Regional variation in percutaneous penetration in man. Pesticides. , 1971, Archives of environmental health.

[19]  J. Jacobsen,et al.  Biochemistry and physiology of taurine and taurine derivatives. , 1968, Physiological reviews.

[20]  H. Maibach,et al.  Regional variation in percutaneous penetration of 14C cortisol in man. , 1967, The Journal of investigative dermatology.