Sumoylation of SMAD 4 ameliorates the oxidative stress‐induced apoptosis in osteoblasts

[1]  Anusi Sarkar,et al.  The SUMO System and TGFβ Signaling Interplay in Regulation of Epithelial-Mesenchymal Transition: Implications for Cancer Progression , 2018, Cancers.

[2]  E. Cho,et al.  Smad4 controls bone homeostasis through regulation of osteoblast/osteocyte viability , 2016, Experimental & Molecular Medicine.

[3]  S. Kook,et al.  Smad4 in osteoblasts exerts a differential impact on HSC fate depending on osteoblast maturation stage , 2016, Leukemia.

[4]  Yi-Ping Li,et al.  TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease , 2016, Bone Research.

[5]  Mohd Ali Hashim,et al.  Superoxide Ion: Generation and Chemical Implications. , 2016, Chemical reviews.

[6]  F. Wang,et al.  Oxidative stress is responsible for maternal diabetes-impaired transforming growth factor beta signaling in the developing mouse heart. , 2015, American journal of obstetrics and gynecology.

[7]  J. Voorhees,et al.  Oxidative exposure impairs TGF-β pathway via reduction of type II receptor and SMAD3 in human skin fibroblasts , 2014, AGE.

[8]  K. Schröder NADPH oxidases in bone homeostasis and osteoporosis , 2014, Cellular and Molecular Life Sciences.

[9]  Xuejun Guo,et al.  BMP-2 Up-Regulates PTEN Expression and Induces Apoptosis of Pulmonary Artery Smooth Muscle Cells under Hypoxia , 2012, PloS one.

[10]  Jianxin Hu,et al.  Hydrogen peroxide-induced cellular apoptosis is mediated by TGF-β2 signaling pathway in cultured human lens epithelial cells , 2010, International Ophthalmology.

[11]  S. Jackson,et al.  Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks , 2009, Nature.

[12]  F. Melchior,et al.  Concepts in sumoylation: a decade on , 2007, Nature Reviews Molecular Cell Biology.

[13]  A. Vertegaal Small ubiquitin-related modifiers in chains. , 2007, Biochemical Society transactions.

[14]  Ji-shuai Zhang,et al.  Smad4 is required for maintaining normal murine postnatal bone homeostasis , 2007, Journal of Cell Science.

[15]  J. Fuchs,et al.  Measurements of UV-generated free radicals/reactive oxygen species (ROS) in skin. , 2006, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[16]  R. Hay,et al.  SUMO: a history of modification. , 2005, Molecular cell.

[17]  J. C. Tilak,et al.  Free radicals and antioxidants in human health: current status and future prospects. , 2004, The Journal of the Association of Physicians of India.

[18]  Xia Lin,et al.  Regulation of Smad4 Sumoylation and Transforming Growth Factor-β Signaling by Protein Inhibitor of Activated STAT1* , 2004, Journal of Biological Chemistry.

[19]  Xin-Hua Feng,et al.  SUMO-1/Ubc9 Promotes Nuclear Accumulation and Metabolic Stability of Tumor Suppressor Smad4* , 2003, Journal of Biological Chemistry.

[20]  R. Derynck,et al.  Sumoylation of Smad4, the Common Smad Mediator of Transforming Growth Factor-β Family Signaling* , 2003, Journal of Biological Chemistry.

[21]  F. Melchior,et al.  Activation of Transforming Growth Factor-β Signaling by SUMO-1 Modification of Tumor Suppressor Smad4/DPC4* , 2003, Journal of Biological Chemistry.