Fibronectins in vascular morphogenesis

[1]  Kairbaan Hodivala-Dilke,et al.  alphavbeta3 integrin and angiogenesis: a moody integrin in a changing environment. , 2008, Current opinion in cell biology.

[2]  R. Keller,et al.  Live imaging of cell protrusive activity, and extracellular matrix assembly and remodeling during morphogenesis in the frog, Xenopus laevis , 2008, Developmental dynamics : an official publication of the American Association of Anatomists.

[3]  E. White,et al.  New insights into form and function of fibronectin splice variants , 2008, The Journal of pathology.

[4]  D. Hanahan,et al.  Modes of resistance to anti-angiogenic therapy , 2008, Nature Reviews Cancer.

[5]  Bin Zhou,et al.  Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart , 2008, Nature.

[6]  Yunfu Sun,et al.  A myocardial lineage derives from Tbx18 epicardial cells , 2008, Nature.

[7]  R. Braren,et al.  Cell-autonomous requirement for β1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice , 2008, Development.

[8]  A. Villa,et al.  A high‐affinity human monoclonal antibody specific to the alternatively spliced EDA domain of fibronectin efficiently targets tumor neo‐vasculature in vivo , 2008, International journal of cancer.

[9]  T. Noda,et al.  Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells. , 2008, Molecular biology of the cell.

[10]  Denis Wirtz,et al.  Fibronectin fibrillogenesis regulates three-dimensional neovessel formation. , 2008, Genes & development.

[11]  G. Davis,et al.  Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling , 2008, Journal of Cell Science.

[12]  F. Baralle,et al.  Absence of regulated splicing of fibronectin EDA exon reduces atherosclerosis in mice. , 2008, Atherosclerosis.

[13]  R. Hynes,et al.  Identification of the Peptide Sequences within the EIIIA (EDA) Segment of Fibronectin That Mediate Integrin α9β1-dependent Cellular Activities* , 2008, Journal of Biological Chemistry.

[14]  R. Hynes,et al.  Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin. , 2007, Developmental biology.

[15]  Scott E Fraser,et al.  Vascular remodeling of the mouse yolk sac requires hemodynamic force , 2007, Development.

[16]  Julio D Amigo,et al.  pak2a mutations cause cerebral hemorrhage in redhead zebrafish , 2007, Proceedings of the National Academy of Sciences.

[17]  M. Daly,et al.  Heart development in fibronectin-null mice is governed by a genetic modifier on chromosome four , 2007, Mechanisms of Development.

[18]  T. Mccauley,et al.  Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102. , 2007, Cancer research.

[19]  S. Conway,et al.  Cardiovascular Development and the Colonizing Cardiac Neural Crest Lineage , 2007, TheScientificWorldJournal.

[20]  J. Takagi,et al.  The RGD motif in fibronectin is essential for development but dispensable for fibril assembly , 2007, The Journal of cell biology.

[21]  Richard O. Hynes.  Cell–matrix adhesion in vascular development , 2007, Journal of thrombosis and haemostasis : JTH.

[22]  M. Majesky.  Developmental basis of vascular smooth muscle diversity. , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[23]  S. Tsukita,et al.  Requirement of ZO-1 for the formation of belt-like adherens junctions during epithelial cell polarization , 2007, The Journal of cell biology.

[24]  K. Furie,et al.  Heart disease and stroke statistics--2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. , 2007, Circulation.

[25]  J. Epstein,et al.  An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. , 2007, The Journal of clinical investigation.

[26]  R. Roberts,et al.  A Dynamic Epicardial Injury Response Supports Progenitor Cell Activity during Zebrafish Heart Regeneration , 2006, Cell.

[27]  Jacqueline Murray,et al.  Heparin-II Domain of Fibronectin Is a Vascular Endothelial Growth Factor-Binding Domain: Enhancement of VEGF Biological Activity by a Singular Growth Factor/Matrix Protein Synergism , 2006, Circulation research.

[28]  T. Matsui,et al.  ZO-1 and ZO-2 Independently Determine Where Claudins Are Polymerized in Tight-Junction Strand Formation , 2006, Cell.

[29]  George E. Davis,et al.  Endothelial tubes assemble from intracellular vacuoles in vivo , 2006, Nature.

[30]  K. Konstantopoulos,et al.  Defective blood vessel development and pericyte/pvSMC distribution in alpha 4 integrin-deficient mouse embryos. , 2006, Developmental biology.

[31]  L. Zardi,et al.  Fibronectin as target for tumor therapy , 2006, International journal of cancer.

[32]  C. Betsholtz,et al.  Pericytes and vascular stability. , 2006, Experimental cell research.

[33]  G. Cossu,et al.  Smooth muscle of the dorsal aorta shares a common clonal origin with skeletal muscle of the myotome , 2006, Development.

[34]  Janet Rossant,et al.  Endothelial cells and VEGF in vascular development , 2005, Nature.

[35]  Steven Song,et al.  The role of pericytes in blood-vessel formation and maintenance. , 2005, Neuro-oncology.

[36]  C. Betsholtz,et al.  Endothelial/Pericyte Interactions , 2005, Circulation research.

[37]  F. Bussolino,et al.  Stable interaction between α5β1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1 , 2005, The Journal of cell biology.

[38]  Micah Dembo,et al.  The dynamics and mechanics of endothelial cell spreading. , 2005, Biophysical journal.

[39]  M. Luisa Iruela-Arispe,et al.  Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors , 2005, The Journal of cell biology.

[40]  H. Kondoh,et al.  Integrinalpha5-dependent fibronectin accumulation for maintenance of somite boundaries in zebrafish embryos. , 2005, Developmental cell.

[41]  S. Karlsson,et al.  Inactivation of TGFbeta signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome. , 2005, Genes & development.

[42]  D. Sheppard,et al.  The Lymphangiogenic Vascular Endothelial Growth Factors VEGF-C and -D Are Ligands for the Integrin α9β1* , 2005, Journal of Biological Chemistry.

[43]  R. Jain.  Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy , 2005, Science.

[44]  D. Hanahan,et al.  Direct Test of Potential Roles of EIIIA and EIIIB Alternatively Spliced Segments of Fibronectin in Physiological and Tumor Angiogenesis , 2004, Molecular and Cellular Biology.

[45]  J. Peters,et al.  Deletion of the alternatively spliced fibronectin EIIIA domain in mice reduces atherosclerosis. , 2004, Blood.

[46]  G. Owens,et al.  Molecular regulation of vascular smooth muscle cell differentiation in development and disease. , 2004, Physiological reviews.

[47]  Le A. Trinh,et al.  Fibronectin regulates epithelial organization during myocardial migration in zebrafish. , 2004, Developmental cell.

[48]  Geert Carmeliet,et al.  Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival. , 2004, The Journal of clinical investigation.

[49]  Guido Tarone,et al.  Positional control of cell fate through joint integrin/receptor protein kinase signaling. , 2003, Annual review of cell and developmental biology.

[50]  C. Betsholtz,et al.  Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors. , 2003, The Journal of clinical investigation.

[51]  K. Hirschi,et al.  Gap Junction Communication Mediates Transforming Growth Factor-&bgr; Activation and Endothelial-Induced Mural Cell Differentiation , 2003, Circulation research.

[52]  J. Schwarzbauer,et al.  The ins and outs of fibronectin matrix assembly , 2003, Journal of Cell Science.

[53]  U. Landegren,et al.  Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall. , 2003, Genes & development.

[54]  Da-Zhi Wang,et al.  The serum response factor coactivator myocardin is required for vascular smooth muscle development , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[55]  P. Carmeliet.  Angiogenesis in health and disease , 2003, Nature Medicine.

[56]  D. Hanahan,et al.  Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. , 2003, The Journal of clinical investigation.

[57]  L. Zardi,et al.  Selective targeting of tumoral vasculature: Comparison of different formats of an antibody (L19) to the ED‐B domain of fibronectin , 2002, International journal of cancer.

[58]  R. Hynes,et al.  Defective Associations between Blood Vessels and Brain Parenchyma Lead to Cerebral Hemorrhage in Mice Lacking αv Integrins , 2002, Molecular and Cellular Biology.

[59]  Ruediger C. Braun-Dullaeus,et al.  Vascular proliferation and atherosclerosis: New perspectives and therapeutic strategies , 2002, Nature Medicine.

[60]  G. Viale,et al.  Differentiation between high- and low-grade astrocytoma using a human recombinant antibody to the extra domain-B of fibronectin. , 2002, The American journal of pathology.

[61]  Salman Rahman,et al.  Novel Vascular Endothelial Growth Factor Binding Domains of Fibronectin Enhance Vascular Endothelial Growth Factor Biological Activity , 2002, Circulation research.

[62]  G. Dangas,et al.  Cardiology patient page. Restenosis: repeat narrowing of a coronary artery: prevention and treatment. , 2002, Circulation.

[63]  D. Davidson,et al.  Central roles of alpha5beta1 integrin and fibronectin in vascular development in mouse embryos and embryoid bodies. , 2002, Arteriosclerosis, thrombosis, and vascular biology.

[64]  D. Sheppard,et al.  The EIIIA Segment of Fibronectin Is a Ligand for Integrins α9β1 and α4β1Providing a Novel Mechanism for Regulating Cell Adhesion by Alternative Splicing* , 2002, The Journal of Biological Chemistry.

[65]  Rakesh K Jain,et al.  Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. , 2002, The American journal of pathology.

[66]  E. Ruoslahti.  Specialization of tumour vasculature , 2002, Nature Reviews Cancer.

[67]  M. Marsden,et al.  Regulation of cell polarity, radial intercalation and epiboly in Xenopus: novel roles for integrin and fibronectin. , 2001, Development.

[68]  D. Taverna,et al.  Reduced blood vessel formation and tumor growth in alpha5-integrin-negative teratocarcinomas and embryoid bodies. , 2001, Cancer research.

[69]  J P Ornato,et al.  Cardiology patient page: warning signs of a heart attack. , 2001, Circulation.

[70]  Jerome F. Strauss,et al.  The Extra Domain A of Fibronectin Activates Toll-like Receptor 4* , 2001, The Journal of Biological Chemistry.

[71]  J. L. Swain,et al.  Maintenance of Vascular Integrity in the Embryo Requires Signaling through the Fibroblast Growth Factor Receptor* , 2000, The Journal of Biological Chemistry.

[72]  Robert V Farese,et al.  Fatal Bilateral Chylothorax in Mice Lacking the Integrin α9β1 , 2000, Molecular and Cellular Biology.

[73]  G. Davis,et al.  RGD-Dependent Vacuolation and Lumen Formation Observed during Endothelial Cell Morphogenesis in Three-Dimensional Fibrin Matrices Involves the αvβ3 and α5β1 Integrins , 2000 .

[74]  R. Hynes,et al.  Overlapping and independent functions of fibronectin receptor integrins in early mesodermal development. , 1999, Developmental biology.

[75]  H. Kosmehl,et al.  Distribution of laminin and fibronectin isoforms in oral mucosa and oral squamous cell carcinoma , 1999, British Journal of Cancer.

[76]  C. Betsholtz,et al.  Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. , 1999, Development.

[77]  L. Zardi,et al.  Expression of EDA/EDB isoforms of fibronectin in papillary carcinoma of the thyroid , 1999, The Journal of pathology.

[78]  Willem Flameng,et al.  Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188 , 1999, Nature Medicine.

[79]  D. Hanahan,et al.  Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. , 1999, Science.

[80]  T. Sakakura,et al.  Expression of Fibronectin Isoforms in Human Breast Tissue: Production of Extra Domain A+/Extra Domain B+ by Cancer Cells and Extra Domain A+ by Stromal Cells , 1999, Japanese journal of cancer research : Gann.

[81]  R. Hynes,et al.  Extensive Vasculogenesis, Angiogenesis, and Organogenesis Precede Lethality in Mice Lacking All αv Integrins , 1998, Cell.

[82]  Y. Kanemura,et al.  Role of fibronectin-stimulated tumor cell migration in glioma invasion in vivo: clinical significance of fibronectin and fibronectin receptor expressed in human glioma tissues , 1998, Clinical & Experimental Metastasis.

[83]  A. Geinoz,et al.  The Fibronectin Domain ED-A Is Crucial for Myofibroblastic Phenotype Induction by Transforming Growth Factor-β1 , 1998, The Journal of cell biology.

[84]  S. Uccini,et al.  Intratumoral microvessel density and expression of ED-A/ED-B sequences of fibronectin in breast carcinoma. , 1998, European journal of cancer.

[85]  R. Hynes,et al.  Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells. , 1997, Blood.

[86]  E. Keshet,et al.  Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[87]  J. Peters,et al.  Expression of fibronectin splicing variants in organ transplantation: a differential pattern between rat cardiac allografts and isografts. , 1997, The American journal of pathology.

[88]  Pamela F. Jones,et al.  Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis , 1996, Cell.

[89]  K. Yamada,et al.  Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors , 1996, The Journal of cell biology.

[90]  R. Hynes,et al.  Fibronectin receptor functions in embryonic cells deficient in alpha 5 beta 1 integrin can be replaced by alpha V integrins. , 1996, Molecular biology of the cell.

[91]  R. Hynes,et al.  Mesodermal development in mouse embryos mutant for fibronectin , 1996, Developmental dynamics : an official publication of the American Association of Anatomists.

[92]  Kenneth J. Hillan,et al.  Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene , 1996, Nature.

[93]  M. Moutet,et al.  Expression of fibronectin ED-A+ and ED-B+ isoforms by human and experimental colorectal cancer. Contribution of cancer cells and tumor-associated myofibroblasts. , 1996, The American journal of pathology.

[94]  L. Kangas,et al.  Tenascin and fibronectin isoforms in human renal cell carcinomas, renal cell carcinoma cell lines and xenografts in nude mice , 1995, International journal of cancer.

[95]  K. Kent,et al.  Balloon catheterization induced arterial expression of embryonic fibronectins. , 1995, Arteriosclerosis, thrombosis, and vascular biology.

[96]  M. Yasutomi,et al.  Localization of oncofetal and normal fibronectin in colorectal cancer. Correlation with histologic grade, liver metastasis, and prognosis , 1995, Cancer.

[97]  A. Kulkarni,et al.  Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice. , 1995, Development.

[98]  L. Zardi,et al.  The fibronectin isoform containing the ed‐b oncofetal domain: A marker of angiogenesis , 1994, International journal of cancer.

[99]  H. Erickson,et al.  Reversible unfolding of fibronectin type III and immunoglobulin domains provides the structural basis for stretch and elasticity of titin and fibronectin. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[100]  S. Aota,et al.  The short amino acid sequence Pro-His-Ser-Arg-Asn in human fibronectin enhances cell-adhesive function. , 1994, The Journal of biological chemistry.

[101]  L. Zardi,et al.  Distribution of oncofetal fibronectin isoforms in normal, hyperplastic and neoplastic human breast tissues , 1994, International journal of cancer.

[102]  R. Hynes,et al.  Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. , 1993, Development.

[103]  J. Thiery,et al.  Accumulation of fetal fibronectin mRNAs during the development of rat cardiac hypertrophy induced by pressure overload. , 1991, The Journal of clinical investigation.

[104]  V. Koteliansky,et al.  Expression of extra domain A fibronectin sequence in vascular smooth muscle cells is phenotype dependent , 1989, Journal of Cell Biology.

[105]  K. Titani,et al.  Deregulation of alternative splicing of fibronectin pre-mRNA in malignant human liver tumors. , 1989, The Journal of biological chemistry.

[106]  R. Hynes,et al.  Patterns of fibronectin gene expression and splicing during cell migration in chicken embryos. , 1988, Development.

[107]  Tracy T Batchelor,et al.  AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. , 2007, Cancer cell.

[108]  D. Taverna,et al.  The diverse roles of integrins and their ligands in angiogenesis. , 2002, Cold Spring Harbor symposia on quantitative biology.

[109]  H. Kosmehl,et al.  Targeted delivery of tissue factor to the ED-B domain of fibronectin, a marker of angiogenesis, mediates the infarction of solid tumors in mice. , 2001, Cancer research.

[110]  D. Dean,et al.  Expanding Roles for α4 Integrin and its Ligands in Development , 1994 .