Estimating Incidence Curves of Several Infections Using Symptom Surveillance Data

We introduce a method for estimating incidence curves of several co-circulating infectious pathogens, where each infection has its own probabilities of particular symptom profiles. Our deconvolution method utilizes weekly surveillance data on symptoms from a defined population as well as additional data on symptoms from a sample of virologically confirmed infectious episodes. We illustrate this method by numerical simulations and by using data from a survey conducted on the University of Michigan campus. Last, we describe the data needs to make such estimates accurate.

[1]  C. King,et al.  Estimating pathogen-specific asymptomatic ratios. , 2010, Epidemiology.

[2]  Richard K. Zimmerman,et al.  Seroprevalence Following the Second Wave of Pandemic 2009 H1N1 Influenza in Pittsburgh, PA, USA , 2010, PloS one.

[3]  Paul A. Biedrzycki,et al.  The severity of pandemic H1N1 influenza in the United States, April – July 2009 , 2010, PLoS currents.

[4]  Joshua B. Plotkin,et al.  Reconstructing influenza incidence by deconvolution of daily mortality time series , 2009, Proceedings of the National Academy of Sciences.

[5]  M. Lipsitch,et al.  The Severity of Pandemic H1N1 Influenza in the United States, from April to July 2009: A Bayesian Analysis , 2009, PLoS medicine.

[6]  Xiao-Li Meng,et al.  Using EM to Obtain Asymptotic Variance-Covariance Matrices: The SEM Algorithm , 1991 .

[7]  N. Ferguson,et al.  Time lines of infection and disease in human influenza: a review of volunteer challenge studies. , 2008, American journal of epidemiology.

[8]  D. Cummings,et al.  Strategies for containing an emerging influenza pandemic in Southeast Asia , 2005, Nature.

[9]  Lam,et al.  Iterative statistical approach to blind image deconvolution , 2000, Journal of the Optical Society of America. A, Optics, image science, and vision.

[10]  G. McLachlan,et al.  The EM algorithm and extensions , 1996 .

[11]  Brendan Giles,et al.  Seroprevalence Following the Second Wave of Pandemic 2009 H1N1 Influenza , 2010, PLoS currents.

[12]  R. Bailey,et al.  Hong Kong influenza: the epidemiologic features of a high school family study analyzed and compared with a similar study during the 1957 Asian influenza epidemic. , 1970, American journal of epidemiology.

[13]  L. Lucy An iterative technique for the rectification of observed distributions , 1974 .

[14]  Ying Lu,et al.  Verbal Autopsy Methods with Multiple Causes of Death , 2008, 0808.0645.

[15]  William H. Richardson,et al.  Bayesian-Based Iterative Method of Image Restoration , 1972 .

[16]  O. Keene,et al.  Diagnosis of influenza in the community: relationship of clinical diagnosis to confirmed virological, serologic, or molecular detection of influenza. , 2001, Archives of internal medicine.

[17]  D. Rubin,et al.  Maximum likelihood from incomplete data via the EM - algorithm plus discussions on the paper , 1977 .

[18]  S. Leach,et al.  Modeling Legionnaires' Disease Outbreaks: Estimating the Timing of an Aerosolized Release Using Symptom-onset Dates , 2011, Epidemiology.

[19]  Dennis KM Ip,et al.  A profile of the online dissemination of national influenza surveillance data , 2009, BMC public health.

[20]  S. V. van Noort,et al.  Gripenet: an internet-based system to monitor influenza-like illness uniformly across Europe. , 2007, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[21]  Mitchell H. Gail,et al.  A Method for Obtaining Short-Term Projections and Lower Bounds on the Size of the AIDS Epidemic , 1988 .

[22]  F. Hayden,et al.  Symptom Profile of Common Colds in School-Aged Children , 2008, The Pediatric infectious disease journal.

[23]  Karen Ekernas,et al.  Facemasks and Hand Hygiene to Prevent Influenza Transmission in Households: A Cluster Randomized Trial , 2010 .

[24]  K. Shine,et al.  Respiratory Protection for Healthcare Workers in the Workplace Against Novel H1N1 Influenza A: A Letter Report , 2009 .