The Glu318Gly substitution in presenilin 1 is not causally related to Alzheimer disease.

We are grateful to Hubert Backhovens, Marleen Van den Broeck, and Sally Serneels for their skilled technical assistance in the mutation screening and genotyping. We thank Alewijn Ott, Frans van Harskamp, Inge de Koning, Maarten de Rijk, and Sandra Kalmijn for their contribution in the dementia diagnosis. This work was funded in part by a special research project of the University of Antwerp, the Fund for Scientific Research in Flanders, and the International Alzheimer's disease Research Fund, Belgium; and by the NESTOR stimulation program for scientific research in the Netherlands (Ministry of Health and Ministry of Education), the Netherlands Organisation for Scientific research, the Netherlands Prevention fund, and the municipality of Rotterdam.

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