Investigating the Effect of Granisetron on the Prevention of Hypotension after Spinal Anesthesia in Cesarean Section

In this study, the effect of granisetron on the prevention of hypotension after spinal anesthesia in cesarean section was investigated. In this double blind randomized clinical trial, 60 parturients were divided into two groups: the first group received 3 mg of granisetron intravenously before spinal anesthesia and the second group received saline (placebo) with same volume and in similar syringe. Spinal anesthesia was then performed through the L4-L5 intervertebral space with 10 mg of 0.5% hyperbaric bupivacaine for all patients, and the systolic blood pressure, diastolic blood pressure, mean arterial pressure, and heart rate were measured and recorded every 3 minutes during the operation. After the surgery, patients were transferred to the recovery room. Any side effects during surgery (hypotension-bradycardia (below 50), arrhythmia, headache, chills, etc.) were recorded on the questionnaire. There was no significant difference between the two groups regarding the mean age of participants (P = 0.208). The systolic blood pressure, diastolic blood pressure, mean arterial pressure, and heart rate showed no significant differences between the two groups. Regarding P = 0.413, ephedrine consumption revealed no significant differences between the two groups. No significant difference was found between the groups in terms of headache (P = 0.1), myalgia (P = 0.1), dizziness (P = 0.672), vomiting (P = 0. 672), chills (P = 0. 279), drowsiness (P = 0.797), and nausea (P = 0.672). According to the results of this study and few studies on the effect of granisetron, further studies are recommended to examine the granisetron effect in combination with crystalloid fluid infusion on hemodynamic variables in parturients undergoing cesarean section.