Crystal Structure of the Tyrosine Phosphatase SHP-2

[1]  T. Pawson Protein Modules and Signaling Networks , 2000 .

[2]  S. Shoelson,et al.  Tandem SH2 Domains Confer High Specificity in Tyrosine Kinase Signaling* , 1998, The Journal of Biological Chemistry.

[3]  B. Neel,et al.  Structural Determinants of SHP-2 Function and Specificity in Xenopus Mesoderm Induction , 1998, Molecular and Cellular Biology.

[4]  G. Superti-Furga,et al.  The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions. , 1997, Journal of molecular biology.

[5]  D. Barford,et al.  The Crystal Structure of Domain 1 of Receptor Protein-tyrosine Phosphatase μ* , 1997, The Journal of Biological Chemistry.

[6]  D. Jackson,et al.  Characterization of Phosphotyrosine Binding Motifs in the Cytoplasmic Domain of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1) That Are Required for the Cellular Association and Activation of the Protein-tyrosine Phosphatase, SHP-2* , 1997, The Journal of Biological Chemistry.

[7]  S. Rhee,et al.  Regulation of Phosphoinositide-specific Phospholipase C Isozymes* , 1997, The Journal of Biological Chemistry.

[8]  T. Pawson,et al.  Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp‐2 , 1997, The EMBO journal.

[9]  B. Neel,et al.  Protein tyrosine phosphatases in signal transduction. , 1997, Current opinion in cell biology.

[10]  A. Ullrich,et al.  A family of proteins that inhibit signalling through tyrosine kinase receptors , 1997, Nature.

[11]  John Kuriyan,et al.  Crystal structure of the Src family tyrosine kinase Hck , 1997, Nature.

[12]  Michael J. Eck,et al.  Three-dimensional structure of the tyrosine kinase c-Src , 1997, Nature.

[13]  M. Kasuga,et al.  A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion , 1996, Molecular and cellular biology.

[14]  J. Livingston,et al.  Insulin Signaling in Mice Expressing Reduced Levels of Syp* , 1996, The Journal of Biological Chemistry.

[15]  J. Noel,et al.  Structural basis for inhibition of receptor protein-tyrosine phosphatase-α by dimerization , 1996, Nature.

[16]  B. Matthews,et al.  Thermodynamic and structural compensation in "size-switch" core repacking variants of bacteriophage T4 lysozyme. , 1996, Journal of molecular biology.

[17]  H. McNeill,et al.  The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf. , 1996, Development.

[18]  B. Matthews,et al.  THERMODYNAMIC AND STRUCTURAL COMPENSATION IN ""SIZE-SWITCH"" CORE-REPACKING VARIANTS OF T4 LYSOZYME , 1996 .

[19]  B. Neel,et al.  Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression , 1996, Molecular and cellular biology.

[20]  C. Walsh,et al.  Differential functions of the two Src homology 2 domains in protein tyrosine phosphatase SH-PTP1. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[21]  S. Harrison,et al.  Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2 , 1996, Nature.

[22]  D. Barford,et al.  Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B. , 1995, Science.

[23]  J. Brugge,et al.  Syk Is Activated by Phosphotyrosine-containing Peptides Representing the Tyrosine-based Activation Motifs of the High Affinity Receptor for IgE(*) , 1995, The Journal of Biological Chemistry.

[24]  R. Rowley,et al.  Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation , 1995, The Journal of Biological Chemistry.

[25]  C. Walsh,et al.  Potent Stimulation of SH-PTP2 Phosphatase Activity by Simultaneous Occupancy of Both SH2 Domains (*) , 1995, The Journal of Biological Chemistry.

[26]  Tony Pawson,et al.  Protein modules and signalling networks , 1995, Nature.

[27]  B. Neel,et al.  The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early xenopus development , 1995, Cell.

[28]  D. Baltimore,et al.  Modular binding domains in signal transduction proteins , 1995, Cell.

[29]  C. Walsh,et al.  Intramolecular regulation of protein tyrosine phosphatase SH-PTP1: a new function for Src homology 2 domains. , 1994, Biochemistry.

[30]  M. Welham,et al.  Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase. , 1994, The Journal of biological chemistry.

[31]  Collaborative Computational,et al.  The CCP4 suite: programs for protein crystallography. , 1994, Acta crystallographica. Section D, Biological crystallography.

[32]  E. Fauman,et al.  Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 Å and the complex with tungstate , 1994, Nature.

[33]  C. Walsh,et al.  Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1. , 1994, The Journal of biological chemistry.

[34]  J. Kuriyan,et al.  Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase. , 1994, Structure.

[35]  D. Barford,et al.  Crystal structure of human protein tyrosine phosphatase 1B. , 1994, Science.

[36]  F. Jirik,et al.  Characterization of protein tyrosine phosphatase SH-PTP2. Study of phosphopeptide substrates and possible regulatory role of SH2 domains. , 1994, The Journal of biological chemistry.

[37]  D. Banville,et al.  Inhibition of the activity of protein tyrosine phosphate 1C by its SH2 domains. , 1993, Biochemistry.

[38]  A. Fersht,et al.  Structure of the hydrophobic core in the transition state for folding of chymotrypsin inhibitor 2: a critical test of the protein engineering method of analysis. , 1993, Biochemistry.

[39]  A. Fersht,et al.  Effect of cavity-creating mutations in the hydrophobic core of chymotrypsin inhibitor 2. , 1993, Biochemistry.

[40]  C. Walsh,et al.  Expression, purification, and characterization of SH2-containing protein tyrosine phosphatase, SH-PTP2. , 1993, The Journal of biological chemistry.

[41]  C. Walsh,et al.  Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor. , 1993, The Journal of biological chemistry.

[42]  T. Pawson,et al.  The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp. , 1993, The Journal of biological chemistry.

[43]  L. Cantley,et al.  Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit. , 1993, The Journal of biological chemistry.

[44]  A. Ullrich,et al.  Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. , 1993, Science.

[45]  T. Pawson,et al.  SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. , 1993, Science.

[46]  B. Margolis,et al.  Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation. , 1992, The EMBO journal.

[47]  N. Perrimon,et al.  corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso , 1992, Cell.

[48]  P. Fitzgerald,et al.  Molecular replacement , 1992 .

[49]  B. Matthews,et al.  Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect. , 1992, Science.

[50]  K. Sharp,et al.  Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons , 1991, Proteins.

[51]  P. Kraulis A program to produce both detailed and schematic plots of protein structures , 1991 .

[52]  M. Carson RIBBONS 2.0 , 1991 .

[53]  J. Kinet The high-affinity receptor for IgE. , 1990, Current opinion in immunology.

[54]  Wolfgang Kabsch,et al.  Evaluation of Single-Crystal X-ray Diffraction Data from a Position-Sensitive Detector , 1988 .

[55]  D Cowburn,et al.  Modular peptide recognition domains in eukaryotic signaling. , 1997, Annual review of biophysics and biomolecular structure.

[56]  N. Tonks Protein tyrosine phosphatases and the control of cellular signaling responses. , 1996, Advances in pharmacology.

[57]  Axel T. Brunger,et al.  X-PLOR Version 3.1: A System for X-ray Crystallography and NMR , 1992 .

[58]  F. Richards,et al.  Identification of structural motifs from protein coordinate data: Secondary structure and first‐level supersecondary structure * , 1988, Proteins.