Response:Resistance of naturally occurring regulatory T cells toward oxidative stress: possible link with intracellular catecholamine content and implications for cancer therapy

Response: Dr Cosentino et al in their letter to the editor discuss our previous report demonstrating increased resistance of regulatory T cells (Tregs) toward oxidative stress[1][1] in the context of their findings on a catecholamine (CA) dependent inhibitory functional loop in Tregs.[2][2] Their

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[11]  G. Nappi,et al.  Dopaminergic modulation of oxidative stress and apoptosis in human peripheral blood lymphocytes: evidence for a D1-like receptor-dependent protective effect. , 2004, Free radical biology & medicine.

[12]  S. Ben-Eliyahu.  The promotion of tumor metastasis by surgery and stress: Immunological basis and implications for psychoneuroimmunology , 2003, Brain, Behavior, and Immunity.

[13]  A. Ghezzi,et al.  Catecholamine production and tyrosine hydroxylase expression in peripheral blood mononuclear cells from multiple sclerosis patients: effect of cell stimulation and possible relevance for activation-induced apoptosis , 2002, Journal of Neuroimmunology.

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[15]  A. Sidhu,et al.  Increased oxidative stress in renal proximal tubules of the spontaneously hypertensive rat: A mechanism for defective dopamine D1A receptor/G‐protein coupling , 1998, Journal of hypertension.

[16]  G. Comi,et al.  Interferon-gamma and interferon-beta affect endogenous catecholamines in human peripheral blood mononuclear cells: implications for multiple sclerosis. , 2005, Journal of neuroimmunology.