Analysis of modified oligonucleotides with capillary gel electrophoresis.

[1]  K. Fearon,et al.  Comparison of binding of N3'-->P5' phosphoramidate and phosphorothioate oligonucleotides to cell surface proteins of cultured cells. , 1999, Antisense & nucleic acid drug development.

[2]  J. Nelson,et al.  Analysis of an oligonucleotide N3′→ P5′ phosphoramidate/phosphorothioate chimera with capillary gel electrophoresis , 1998, Electrophoresis.

[3]  S. Mccurdy,et al.  An improved synthesis of oligodeoxynucleotide N3'-->P5' phosphoramidates and their chimera using hindered phosphoramidite monomers and a novel handle for reverse phase purification. , 1998, Nucleic acids research.

[4]  S. Mccurdy,et al.  N3'-->P5' Oligodeoxyribonucleotide Phosphoramidates: A New Method of Synthesis Based on a Phosphoramidite Amine-Exchange Reaction. , 1997, The Journal of organic chemistry.

[5]  S. Agrawal,et al.  Mixed-backbone oligonucleotides as second generation antisense oligonucleotides: in vitro and in vivo studies. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[6]  M. Nerenberg,et al.  RNase H-independent antisense activity of oligonucleotide N3 '--> P5 ' phosphoramidates. , 1997, Nucleic acids research.

[7]  S. Mccurdy,et al.  An improved method for the synthesis of N3′→P5′ phosphoramidate oligonucleotides , 1997 .

[8]  M. Matteucci.  Structural modifications toward improved antisense oligonucleotides , 1996 .

[9]  D. Fabbro,et al.  Second-generation antisense oligonucleotides: structure-activity relationships and the design of improved signal-transduction inhibitors. , 1996, Biochemical Society transactions.

[10]  D. Lloyd,et al.  Capillary gel electrophoresis and antisense therapeutics. Analysis of DNA analogs. , 1996, Journal of chromatography. A.

[11]  G. Hermanson.  Tags and Probes , 1996 .

[12]  K. Fearon,et al.  Investigation of the 'n-1' impurity in phosphorothioate oligodeoxynucleotides synthesized by the solid-phase beta-cyanoethyl phosphoramidite method using stepwise sulfurization. , 1995, Nucleic acids research.

[13]  L. DeDionisio,et al.  Analysis of a ribonuclease H digestion of N3'-->P5' phosphoramidate-RNA duplexes by capillary gel electrophoresis. , 1995, Journal of chromatography. B, Biomedical applications.

[14]  J. Bisi,et al.  An assessment of the antisense properties of RNase H-competent and steric-blocking oligomers. , 1995, Nucleic acids research.

[15]  A. Gewirtz,et al.  Binding, uptake, and intracellular trafficking of phosphorothioate-modified oligodeoxynucleotides. , 1995, The Journal of clinical investigation.

[16]  D. Lloyd,et al.  Oligonucleotide N3'-->P5' phosphoramidates. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[17]  W. Stec,et al.  Analysis of oligo(deoxynucleoside phosphorothioate)s and their diastereomeric composition. , 1995, Nucleic acids research.

[18]  J. Murtagh,et al.  A rapid, reliable method for detection of known point mutations: point-EXACCT. , 1994, Nucleic acids research.

[19]  M. Nerenberg,et al.  Effect of phosphorothioate modification of oligodeoxynucleotides on specific protein binding. , 1994, The Journal of biological chemistry.

[20]  R. H. Carlson,et al.  Quantitative capillary gel electrophoresis assay of phosphorothioate oligonucleotides in pharmaceutical formulations. , 1994, Journal of chromatography. A.

[21]  M. Vilenchik,et al.  High-performance liquid chromatography and capillary gel electrophoresis as applied to antisense DNA , 1993 .

[22]  J. Engels,et al.  Synthesis and selective cleavage of an oligodeoxynucleotide containing a bridged non-chiral internucleotide 3′-phosphoramidate linkage , 1992 .

[23]  Robert L. Letsinger,et al.  Synthesis and properties of oligonucleotides containing aminodeoxythymidine units , 1992, Nucleic Acids Res..

[24]  A. Murakami,et al.  Fluorescent-labeled oligonucleotide probes: detection of hybrid formation in solution by fluorescence polarization spectroscopy. , 1991, Nucleic acids research.

[25]  A. Pingoud,et al.  Quantitative analysis of polymerase chain reaction (PCR) products using primers labeled with biotin and a fluorescent dye. , 1991, Analytical biochemistry.

[26]  E. Uhlmann,et al.  Antisense oligonucleotides: a new therapeutic principle , 1990 .

[27]  Z. Dominski,et al.  RNase H cleavage of RNA hybridized to oligonucleotides containing methylphosphonate, phosphorothioate and phosphodiester bonds. , 1989, Nucleic acids research.

[28]  W. Bannwarth.  Solid‐Phase Synthesis of Oligodeoxynucleotides containing phosphoramidate internucleotide linkages and their specific chemical cleavage , 1988 .

[29]  F. Eckstein.  Phosphorothioate Analogues of Nucleotides—Tools for the Investigation of Biochemical Processes , 1983 .

[30]  T. Merigan,et al.  The antiviral activity of thiophosphate-substituted polyribonucleotides in vitro and in vivo. , 1970, Virology.