Analytical techniques for the determination of Amphetamine-type substances in different matrices: a comprehensive review

Abstract This current review focuses on contributions to amphetamine-type substances (ATS) analysis. This type of synthetic illicit drugs has been increasingly present worldwide reaching 5% of the market on illicit drugs in 2019. The increment of their production in many clandestine laboratories and easy distribution among society are two of the main concerns towards the battle against synthetic drugs. Therefore, the first part of this review details the classification and mechanism of action of ATS in the human body. Second, the pharmacological and toxicological effects of ATS on human health are described to motivate the need of early detection of ATS. Subsequently, the most used laboratory-based and portable methods are presented and critically discussed along the review. Finally, a careful discussion on the advantages and disadvantages of portable techniques employed on the field are addressed as potential tools for on-site ATS detection by law enforcement officers.

[1]  L. Skender,et al.  Quantitative determination of amphetamines, cocaine, and opiates in human hair by gas chromatography/mass spectrometry. , 2002, Forensic science international.

[2]  Chunhai Fan,et al.  DNA nanostructure-decorated surfaces for enhanced aptamer-target binding and electrochemical cocaine sensors. , 2011, Analytical chemistry.

[3]  Jaleh Barar,et al.  Electrochemical impedance spectroscopic sensing of methamphetamine by a specific aptamer. , 2012, BioImpacts : BI.

[4]  A. Verstraete,et al.  Comparison of the sensitivity and specificity of six immunoassays for the detection of amphetamines in urine. , 2005, Journal of analytical toxicology.

[5]  Gurvinder Singh Bumbrah,et al.  Raman spectroscopy – Basic principle, instrumentation and selected applications for the characterization of drugs of abuse , 2016 .

[6]  Erkki Sippola,et al.  Quantification of the Amphetamine Content in Seized Street Samples by Raman Spectroscopy , 2007, Journal of forensic sciences.

[7]  L. Núñez-Vergara,et al.  Electrochemical oxidation of methylenedioxyamphetamines. , 1993, Talanta: The International Journal of Pure and Applied Analytical Chemistry.

[8]  S. Weis,et al.  Intoxication: Street Drugs , 2019, Imaging Brain Diseases.

[9]  K. Kuwayama,et al.  Forensic application of chiral separation of amphetamine-type stimulants to impurity analysis of seized methamphetamine by capillary electrophoresis. , 2006, Forensic science international.

[10]  A. Fakhari,et al.  Impedimetric and stripping voltammetric determination of methamphetamine at gold nanoparticles-multiwalled carbon nanotubes modified screen printed electrode , 2015 .

[11]  S. Materazzi,et al.  "Lab-on-Click" Detection of Illicit Drugs in Oral Fluids by MicroNIR-Chemometrics. , 2019, Analytical chemistry.

[12]  G. Jürgens,et al.  The prognosis following amphetamine poisoning , 2017, Scandinavian journal of public health.

[13]  H. Maurer,et al.  New Psychoactive Substances: Chemistry, Pharmacology, Metabolism, and Detectability of Amphetamine Derivatives With Modified Ring Systems , 2016, Therapeutic drug monitoring.

[14]  Maiara O. Salles,et al.  Forensics in hand: new trends in forensic devices (2013–2017) , 2018 .

[15]  Y. Yagcı,et al.  An immunoelectrochemical platform for the biosensing of ‘Cocaine use’ , 2017 .

[16]  Ian J Pardoe,et al.  Optimization of Surface-Enhanced Raman Spectroscopy Conditions for Implementation into a Microfluidic Device for Drug Detection. , 2016, Analytical chemistry.

[17]  Sergey Piletsky,et al.  Electrochemical sensing of cocaine in real samples based on electrodeposited biomimetic affinity ligands. , 2019, The Analyst.

[18]  A. Errachid,et al.  A highly selective potentiometric amphetamine microsensor based on all-solid-state membrane using a new ion-pair complex, [3,3′-Co(1,2-closo-C2B9H11)2]− [C9H13NH]+ , 2017, Sensors and Actuators B: Chemical.

[19]  M. Fisichella,et al.  High-throughput dispersive liquid/liquid microextraction (DLLME) method for the rapid determination of drugs of abuse, benzodiazepines and other psychotropic medications in blood samples by liquid chromatography–tandem mass spectrometry (LC-MS/MS) and application to forensic cases , 2015 .

[20]  Kiyoyuki Watanabe,et al.  Determination of methamphetamine in urine in situ using a methamphetamine-sensitive membrane electrode , 1993 .

[21]  Marc Parrilla,et al.  Derivatization of amphetamine to allow its electrochemical detection in illicit drug seizures , 2021 .

[22]  M. Praisler,et al.  Identification of novel illicit amphetamines from vapor-phase FTIR spectra - a chemometrical solution. , 2000, Talanta.

[23]  Hongxia Chen,et al.  A label-free impedimetric sensor for the detection of an amphetamine-type derivative based on cucurbit[7]uril-mediated three-dimensional AuNPs , 2019, Electrochemistry Communications.

[24]  L. Wilson,et al.  Evaluation of a rapid oral fluid point-of-care test for MDMA. , 2007, Journal of analytical toxicology.

[25]  Dong Liang,et al.  Dynamic surface-enhanced Raman spectroscopy and Chemometric methods for fast detection and intelligent identification of methamphetamine and 3, 4-Methylenedioxy methamphetamine in human urine. , 2018, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[26]  M. Akhgari,et al.  Quantitative determination of methamphetamine in oral fluid by liquid–liquid extraction and gas chromatography/mass spectrometry , 2017, Human & experimental toxicology.

[27]  Large-area, uniform and low-cost dual-mode plasmonic naked-eye colorimetry and SERS sensor with handheld Raman spectrometer. , 2016, Nanoscale.

[28]  Xiaomin Wang,et al.  Magnetic molecularly imprinted electrochemical sensors: A review. , 2020, Analytica chimica acta.

[29]  Ralf Zimmermann,et al.  Gas chromatography in combination with fast high-resolution time-of-flight mass spectrometry: Technical overview and perspectives for data visualization , 2020 .

[30]  A. Rajabzadeh,et al.  Recent biosensing advances in the rapid detection of illicit drugs , 2020 .

[31]  Jinhuai Liu,et al.  Surface-Enhanced Raman Spectroscopy on Liquid Interfacial Nanoparticle Arrays for Multiplex Detecting Drugs in Urine. , 2016, Analytical chemistry.

[32]  J. Biller,et al.  Toxicity/Substance Abuse , 2017 .

[33]  Masanori Arita,et al.  Identification of small molecules using accurate mass MS/MS search. , 2018, Mass spectrometry reviews.

[34]  M. He,et al.  Simultaneous quantification of amphetamines, caffeine and ketamine in urine by hollow fiber liquid phase microextraction combined with gas chromatography-flame ionization detector. , 2010, Talanta.

[35]  Liangbao Yang,et al.  Development of surface-enhanced Raman spectroscopy application for determination of illicit drugs: Towards a practical sensor. , 2019, Talanta.

[36]  K. Lemr,et al.  Forensic applications of supercritical fluid chromatography - mass spectrometry. , 2018, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[37]  Lucas Blanes,et al.  A Gas Chromatography-Mass Spectrometry Method for Toxicological Analysis of MDA, MDEA and MDMA in Vitreous Humor Samples from Victims of Car Accidents. , 2018, Journal of analytical toxicology.

[38]  Anatoly V. Zherdev,et al.  Integration of lateral flow and microarray technologies for multiplex immunoassay: application to the determination of drugs of abuse , 2013, Microchimica Acta.

[39]  J. Martens,et al.  Mass-Spectrometry-Based Identification of Synthetic Drug Isomers Using Infrared Ion Spectroscopy , 2020, Analytical chemistry.

[40]  A. Stein,et al.  Rational design of all-solid-state ion-selective electrodes and reference electrodes , 2016 .

[41]  Ling-yan Zhang,et al.  Label-free amperometric immunosensor based on prussian blue as artificial peroxidase for the detection of methamphetamine. , 2014, Analytica chimica acta.

[42]  D. Faria,et al.  Accessing the chemical profile of ecstasy tablets seized in São Paulo (Brazil) by FT-Raman Spectroscopy , 2016 .

[43]  A. Fakhari,et al.  Recent advances in microextraction procedures for determination of amphetamines in biological samples. , 2019, Bioanalysis.

[44]  C. Promptmas,et al.  Development of an Amperometric Immunosensor for the Determination of Methamphetamine in Urine , 2002 .

[45]  Jinhuai Liu,et al.  Detection and direct readout of drugs in human urine using dynamic surface-enhanced Raman spectroscopy and support vector machines. , 2015, Analytical chemistry.

[46]  D J Crouch,et al.  Validation of twelve chemical spot tests for the detection of drugs of abuse. , 2000, Forensic science international.

[47]  F. Borrull,et al.  Capillary electrophoresis and related techniques in the determination of drugs of abuse and their metabolites , 2015 .

[48]  Juan C. Vidal,et al.  A Multi‐electrochemical Competitive Immunosensor for Sensitive Cocaine Determination in Biological Samples , 2016 .

[49]  Bradford D Pendley,et al.  A tutorial on the application of ion-selective electrode potentiometry: an analytical method with unique qualities, unexplored opportunities and potential pitfalls; tutorial. , 2013, Analytica chimica acta.

[50]  M. Bluth,et al.  Liquid Chromatography-Tandem Mass Spectrometry: An Emerging Technology in the Toxicology Laboratory. , 2016, Clinics in laboratory medicine.

[51]  Paolo Berretta,et al.  Determination of different recreational drugs in sweat by headspace solid-phase microextraction gas chromatography mass spectrometry (HS-SPME GC/MS): Application to drugged drivers. , 2016, Journal of pharmaceutical and biomedical analysis.

[52]  G. Ayoko,et al.  Rapid Quantification of Methamphetamine: Using Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR) and Chemometrics , 2013, PloS one.

[53]  D. Barceló,et al.  LC-based analysis of drugs of abuse and their metabolites in urine , 2007 .

[54]  E. Fernandes,et al.  Electrochemical sensing of ecstasy with electropolymerized molecularly imprinted poly(o-phenylenediamine) polymer on the surface of disposable screen-printed carbon electrodes , 2019, Sensors and Actuators B: Chemical.

[55]  Oliver A.H. Jones,et al.  Surface Enhanced Raman Spectroscopy in environmental analysis, monitoring and assessment. , 2020, The Science of the total environment.

[56]  Desire L. Massart,et al.  Exploratory analysis for the automated identification of amphetamines from vapour-phase FTIR spectra , 2000 .

[57]  B. McCord,et al.  The development of paper microfluidic devices for presumptive drug detection , 2015 .

[58]  R. Qi,et al.  Graphene oxide-Fe3O4 nanocomposite magnetic solid phase extraction followed by UHPLC-MS/MS for highly sensitive determination of eight psychoactive drugs in urine samples. , 2020, Talanta.

[59]  E. Bahadır,et al.  Lateral flow assays: Principles, designs and labels , 2016 .

[60]  S. Bell,et al.  A Microfluidic Device for Presumptive Testing of Controlled Substances * , 2007, Journal of forensic sciences.

[61]  Emad L. Izake,et al.  Forensic and homeland security applications of modern portable Raman spectroscopy. , 2010, Forensic science international.

[62]  D. Muñoz,et al.  Hollow-fibre liquid-phase microextraction and gas chromatography-mass spectrometric determination of amphetamines in whole blood. , 2020, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[63]  I. Lednev,et al.  Bloodstains, paintings, and drugs: Raman spectroscopy applications in forensic science , 2018 .

[64]  Jeffrey E. Dick,et al.  Electrochemical sensors for the detection of fentanyl and its analogs: Foundations and recent advances , 2020 .

[65]  C. Meinhart,et al.  Dielectrophoretic Nanoparticle Aggregation for On-Demand Surface Enhanced Raman Spectroscopy Analysis. , 2018, Analytical chemistry.

[66]  D. Cliffel,et al.  Electrochemical sensors and biosensors. , 2012, Analytical chemistry.

[67]  S. Fanali,et al.  Capillary electrophoresis-mass spectrometry , 2020, Hyphenations of Capillary Chromatography with Mass Spectrometry.

[68]  Marc Parrilla,et al.  Electrochemical profiling and LC-MS characterization of synthetic cathinones: from methodology to detection in forensic samples. , 2021, Drug testing and analysis.

[69]  E. Vittinghoff,et al.  Amphetamine-group substances and HIV , 2010, The Lancet.

[70]  Pierre Esseiva,et al.  Providing illicit drugs results in five seconds using ultra-portable NIR technology: An opportunity for forensic laboratories to cope with the trend toward the decentralization of forensic capabilities. , 2020, Forensic science international.

[71]  Shizhuang Weng,et al.  Three-dimensional surface-enhanced Raman scattering hotspots in spherical colloidal superstructure for identification and detection of drugs in human urine. , 2015, Analytical chemistry.

[72]  W. Weinmann,et al.  Determination of the stereoisomeric distribution of R-(-)- and S-(+)-methamphetamine in Thai pills in the legal context of "not inconsiderable quantities". , 2020, Regulatory toxicology and pharmacology : RTP.

[73]  H. Sitte,et al.  Amphetamines, new psychoactive drugs and the monoamine transporter cycle , 2014, Trends in pharmacological sciences.

[74]  Robert P. Sambursky,et al.  Lateral Flow Assays , 2016 .

[75]  P. Dardenne,et al.  Evaluation of a calibration transfer between a bench top and portable Mid-InfraRed spectrometer for cocaine classification and quantification. , 2020, Talanta.

[76]  R. Goodacre,et al.  Application of surface enhanced Raman scattering to the solution based detection of a popular legal high, 5,6-methylenedioxy-2-aminoindane (MDAI). , 2015, The Analyst.

[77]  Keyong Hou,et al.  Potential analytical methods for on-site oral drug test: Recent developments and applications , 2019, TrAC Trends in Analytical Chemistry.

[78]  P. Marriott,et al.  Molecular spectroscopy – Information rich detection for gas chromatography , 2018 .

[79]  P. Campíns-Falcó,et al.  Determination of amphetamines in hair by integrating sample disruption, clean-up and solid phase derivatization. , 2016, Journal of chromatography. A.

[80]  Lynn Dennany,et al.  Electrochemiluminescent detection of methamphetamine and amphetamine. , 2016, Forensic science international.

[81]  Radigya M. Correia,et al.  Portable near infrared spectroscopy applied to abuse drugs and medicine analyses , 2018 .

[82]  Nele Samyn,et al.  Electrochemical fingerprint of street samples for fast on-site screening of cocaine in seized drug powders , 2016, Chemical science.

[83]  F. Tagliaro,et al.  Capillary zone electrophoresis (CZE) coupled to time‐of‐flight mass spectrometry (TOF‐MS) applied to the analysis of illicit and controlled drugs in blood , 2008, Electrophoresis.

[84]  S. Materazzi,et al.  Early detection of emerging street drugs by near infrared spectroscopy and chemometrics. , 2016, Talanta.

[85]  M. Meyer,et al.  Overview of Common Designer Drugs , 2019, Critical Issues in Alcohol and Drugs of Abuse Testing.

[86]  Yeong-Jin Choi,et al.  A Wearable Surface-Enhanced Raman Scattering Sensor for Label-Free Molecular Detection. , 2021, ACS applied materials & interfaces.

[87]  W. Thormann.  Capillary electrophoresis for the determination of drugs in biological fluids , 2020 .

[88]  Agnieszka Zgoła-Grześkowiak,et al.  Dispersive liquid-liquid microextraction , 2011 .

[89]  C. Weyermann,et al.  Applications of a transportable Raman spectrometer for the in situ detection of controlled substances at border controls. , 2011, Forensic science international.

[90]  J. Namieśnik,et al.  Analytical procedures for determination of cocaine and its metabolites in biological samples , 2010 .

[91]  Luis Fermín Capitán-Vallvey,et al.  General-purpose passive wireless point-of-care platform based on smartphone. , 2019, Biosensors & bioelectronics.

[92]  Pascual Campoy Cervera,et al.  Automated Low-Cost Smartphone-Based Lateral Flow Saliva Test Reader for Drugs-of-Abuse Detection , 2015, Sensors.

[93]  E. Uriarte,et al.  Electrochemical and spectroscopic characterisation of amphetamine-like drugs: application to the screening of 3,4-methylenedioxymethamphetamine (MDMA) and its synthetic precursors. , 2007, Analytica chimica acta.

[94]  Craig E. Banks,et al.  hemistry : simultaneous voltammetric detection of MDMA and its fatal counterpart “ Dr Death ” ( PMA ) † , 2015 .

[95]  Nahla A. Abdelshafi,et al.  Microfluidic electrochemical immunosensor for the trace analysis of cocaine in water and body fluids. , 2018, Drug testing and analysis.

[96]  E. Sudhölter,et al.  Electrochemical cocaine (bio)sensing. From solid electrodes to soft junctions , 2019, TrAC Trends in Analytical Chemistry.

[97]  O. Schmitz,et al.  Gas chromatography coupled to atmospheric pressure ionization mass spectrometry (GC-API-MS): review. , 2015, Analytica chimica acta.

[98]  Wendell K. T. Coltro,et al.  Wearable electrochemical sensors for forensic and clinical applications , 2019, TrAC Trends in Analytical Chemistry.

[99]  Alar Ainla,et al.  Open-Source Potentiostat for Wireless Electrochemical Detection with Smartphones , 2018, Analytical chemistry.

[100]  Aiying Song,et al.  Efficient determination of amphetamine and methylamphetamine in human urine using electro-enhanced single-drop microextraction with in-drop derivatization and gas chromatography. , 2019, Analytica chimica acta.

[101]  Snober Ahmed,et al.  Paper-based chemical and biological sensors: Engineering aspects. , 2016, Biosensors & bioelectronics.

[102]  T. Saleh,et al.  Electrochemically pretreated carbon electrodes and their electroanalytical applications – A review , 2019, Journal of Electroanalytical Chemistry.

[103]  Rijun Gui,et al.  Recent advances and future prospects in molecularly imprinted polymers-based electrochemical biosensors. , 2018, Biosensors & bioelectronics.

[104]  Tinglan Zhang,et al.  Detection of methamphetamine and its main metabolite in fingermarks by liquid chromatography-mass spectrometry. , 2015, Forensic science international.

[105]  A. Dasgupta.  Drugs of abuse , 2017 .

[106]  J. Rubim,et al.  The adsorption of methamphetamine on Ag nanoparticles dispersed in agarose gel – Detection of methamphetamine in fingerprints by SERS , 2018, Vibrational Spectroscopy.

[107]  Shuyang Liu,et al.  Wearable electrochemical glove-based sensor for rapid and on-site detection of fentanyl. , 2019, Sensors and actuators. B, Chemical.

[108]  E. Ellinwood.  Assault and homicide associated with amphetamine abuse. , 1971, The American journal of psychiatry.

[109]  P. Dargan,et al.  Synthetic Amphetamine Derivatives , 2013 .

[110]  N. A. Santagati,et al.  Simultaneous determination of amphetamine and one of its metabolites by HPLC with electrochemical detection. , 2002, Journal of pharmaceutical and biomedical analysis.

[111]  A. V. van Nuijs,et al.  Local conversion of redox inactive molecules into redox active ones: A formaldehyde based strategy for the electrochemical detection of illicit drugs containing primary and secondary amines , 2021 .

[112]  Adrian Covaci,et al.  Levamisole: a Common Adulterant in Cocaine Street Samples Hindering Electrochemical Detection of Cocaine. , 2018, Analytical chemistry.

[113]  Marc Parrilla,et al.  Identifying electrochemical fingerprints of ketamine with voltammetry and LC-MS for its detection in seized samples. , 2020, Analytical chemistry.

[114]  Thiago M. G. Cardoso,et al.  Portable analytical platforms for forensic chemistry: A review. , 2018, Analytica chimica acta.

[115]  Zhibin Huang,et al.  Ultrasound-assisted dispersive liquid-liquid microextraction for the determination of seven recreational drugs in human whole blood using gas chromatography-mass spectrometry. , 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[116]  A. de Castro,et al.  An LC-MS/MS methodological approach to the analysis of hair for amphetamine-type-stimulant (ATS) drugs, including selected synthetic cathinones and piperazines. , 2017, Drug testing and analysis.

[117]  W. Jin,et al.  Nanomaterials based electrochemical sensor and biosensor platforms for environmental applications , 2017 .

[118]  Serge Rudaz,et al.  Highly sensitive capillary electrophoresis-mass spectrometry for rapid screening and accurate quantitation of drugs of abuse in urine. , 2013, Analytica chimica acta.

[119]  Calum Morrison,et al.  Common methods for the chiral determination of amphetamine and related compounds II. Capillary electrophoresis and nuclear magnetic resonance , 2012 .

[120]  M. Vojs,et al.  Electrochemical behavior of methamphetamine and its voltammetric determination in biological samples using self-assembled boron-doped diamond electrode , 2014 .

[121]  José L. Silva,et al.  Electrochemical sensors based on molecularly imprinted polymer on nanostructured carbon materials: A review , 2019, Journal of Electroanalytical Chemistry.

[122]  Tasnim Munshi,et al.  Analysis of seized drugs using portable Raman spectroscopy in an airport environment—a proof of principle study , 2008 .

[123]  P. Campíns-Falcó,et al.  Amphetamine and Methamphetamine Determinations in Biological Samples by High Performance Liquid Chromatography. A Review , 1994 .

[124]  Robert G. Weston.  Quick Screening of Crystal Methamphetamine/Methyl Sulfone Exhibits by Raman Spectroscopy , 2010, Journal of forensic sciences.

[125]  Anny Talita Maria da Silva,et al.  Bioanalytical methods for determining ecstasy components in biological matrices: A review , 2018, TrAC Trends in Analytical Chemistry.

[126]  C. Siethoff,et al.  Confirmation testing of amphetamines and designer drugs in human urine by capillary electrophoresis‐ion trap mass spectrometry , 2000, Electrophoresis.

[127]  Cheng-Huang Lin,et al.  Rapid screening and determination of 4‐chloroamphetamine in saliva by paper spray‐mass spectrometry and capillary electrophoresis‐mass spectrometry , 2012, Electrophoresis.

[128]  Karolien De Wael,et al.  Electrochemical strategies for the detection of forensic drugs , 2018, Current Opinion in Electrochemistry.

[129]  Mati Horprathum,et al.  Detection of methamphetamine/amphetamine in human urine based on surface-enhanced Raman spectroscopy and acidulation treatments , 2017 .

[130]  Petr I. Nikitin,et al.  Rapid lateral flow assays based on the quantification of magnetic nanoparticle labels for multiplexed immunodetection of small molecules: application to the determination of drugs of abuse , 2019, Microchimica Acta.

[131]  L. Ray,et al.  Clinical neuroscience of amphetamine-type stimulants: From basic science to treatment development. , 2016, Progress in brain research.

[132]  Vojtech Adam,et al.  Magnetic Nanoparticles: From Design and Synthesis to Real World Applications , 2017, Nanomaterials.

[133]  P. Kanatharana,et al.  A sol–gel colorimetric sensor for methamphetamine detection , 2015 .

[134]  Fabio Augusto,et al.  New Advances in Toxicological Forensic Analysis Using Mass Spectrometry Techniques , 2018, Journal of analytical methods in chemistry.

[135]  S. Piletsky,et al.  Polymer platforms for selective detection of cocaine in street samples adulterated with levamisole. , 2018, Talanta.

[136]  Pingping Zhang,et al.  An up-converting phosphor technology-based lateral flow assay for point-of-collection detection of morphine and methamphetamine in saliva. , 2018, The Analyst.

[137]  P. Vadgama,et al.  Development of a Redox Mediated Amperometric Detection System for Immunoassay. Application to Urinary Amphetamine Screening , 2000 .

[138]  S. Tajima,et al.  Improving Powder Magnetic Core Properties via Application of Thin, Insulating Silica-Nanosheet Layers on Iron Powder Particles , 2016, Nanomaterials.

[139]  Joseph Wang,et al.  CHAPTER 3 – Electrochemical glucose biosensors , 2008 .

[140]  S. Pedersen‐Bjergaard,et al.  Liquid-phase microextraction with porous hollow fibers, a miniaturized and highly flexible format for liquid-liquid extraction. , 2008, Journal of chromatography. A.

[141]  P. Campíns-Falcó,et al.  A solid colorimetric sensor for the analysis of amphetamine-like street samples. , 2016, Analytica chimica acta.

[142]  Jinhuai Liu,et al.  Optimal Hotspots of Dynamic Surfaced-Enhanced Raman Spectroscopy for Drugs Quantitative Detection. , 2017, Analytical chemistry.

[143]  L. Murphy,et al.  Disposable screen printed sensor for the electrochemical detection of delta-9-tetrahydrocannabinol in undiluted saliva , 2016, Chemistry Central Journal.

[144]  M. Shahlaei,et al.  New and sensitive sensor for voltammetry determination of Methamphetamine in biological samples , 2020, Journal of Materials Science: Materials in Electronics.

[145]  Jeff Powell,et al.  An overview of forensic drug testing methods and their suitability for harm reduction point-of-care services , 2017, Harm Reduction Journal.

[146]  Yonghwi Kim,et al.  Point-of-Use Detection of Amphetamine-Type Stimulants with Host-Molecule-Functionalized Organic Transistors , 2017 .

[147]  Junhong Tang,et al.  Sensitive magnetic solid-phase microextraction based on oxide multi-walled carbon-nanotubes for the determination of methylamphetamine and ketamine in human urine and blood , 2015 .

[148]  Jia Li,et al.  Multiplexed lateral flow biosensors: Technological advances for radically improving point-of-care diagnoses. , 2016, Biosensors & bioelectronics.

[149]  Wojciech Piekoszewski,et al.  Analytical methodologies for the determination of benzodiazepines in biological samples. , 2015, Journal of pharmaceutical and biomedical analysis.

[150]  Mirela Praisler,et al.  Artificial intelligence application designed to screen for new psychoactive drugs based on their ATR-FTIR spectra , 2019 .

[151]  Shanlin Fu,et al.  A review of chemical 'spot' tests: A presumptive illicit drug identification technique. , 2018, Drug testing and analysis.

[152]  P. Macdonald,et al.  Low-Intensity Exercise Improves Quality of Life in Patients With Crohn's Disease , 2007, Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine.

[153]  Joseph Wang,et al.  Portable electrochemical systems , 2002 .

[154]  Jihye Kim,et al.  In-line coupling of single-drop microextraction with capillary electrophoresis-mass spectrometry , 2015, Analytical and Bioanalytical Chemistry.

[155]  Niamh Nic Daéid,et al.  The analytical and chemometric procedures used to profile illicit drug seizures. , 2005, Talanta.

[156]  Sara Odoardi,et al.  Rapid and simple procedure for the determination of cathinones, amphetamine‐like stimulants and other new psychoactive substances in blood and urine by GC–MS , 2018, Journal of pharmaceutical and biomedical analysis.

[157]  Yannick Weesepoel,et al.  Rapid and robust on‐scene detection of cocaine in street samples using a handheld near‐infrared spectrometer and machine learning algorithms , 2020, Drug testing and analysis.

[158]  Adrian Covaci,et al.  Illicit drug consumption estimations derived from wastewater analysis: a critical review. , 2011, The Science of the total environment.

[159]  F. Peters,et al.  Screening for and validated quantification of amphetamines and of amphetamine- and piperazine-derived designer drugs in human blood plasma by gas chromatography/mass spectrometry. , 2003, Journal of mass spectrometry : JMS.

[160]  M. Wells,et al.  Analysis of amphetamine and methamphetamine as emerging pollutants in wastewater and wastewater-impacted streams. , 2010, Journal of chromatography. A.

[161]  D. A. Russell,et al.  Drug screening using the sweat of a fingerprint: lateral flow detection of Δ9-tetrahydrocannabinol, cocaine, opiates and amphetamine , 2018, Journal of analytical toxicology.

[162]  A. Merkoçi,et al.  New materials for electrochemical sensing IV. Molecular imprinted polymers , 2002 .

[163]  R. Resende,et al.  The Variability of Ecstasy Tablets Composition in Brazil , 2015, Journal of forensic sciences.

[164]  Alison Beavis,et al.  A review of impurity profiling and synthetic route of manufacture of methylamphetamine, 3,4-methylenedioxymethylamphetamine, amphetamine, dimethylamphetamine and p-methoxyamphetamine. , 2013, Forensic science international.

[165]  Mohamed Abdel-Rehim,et al.  Saliva as an alternative specimen to plasma for drug bioanalysis: A review , 2016 .

[166]  Calum Morrison,et al.  Common methods for the chiral determination of amphetamine and related compounds I. Gas, liquid and thin-layer chromatography , 2011 .

[167]  E. Alipour,et al.  Development of a novel voltammetric sensor for the determination of methamphetamine in biological samples on the pretreated pencil graphite electrode , 2015 .

[168]  Pablo A. Marinho,et al.  Electrochemical detection of 3,4-methylenedioxymethamphetamine (ecstasy) using a boron-doped diamond electrode with differential pulse voltammetry: Simple and fast screening method for application in forensic analysis , 2020 .

[169]  S. Ekins,et al.  Cross-reactivity studies and predictive modeling of “Bath Salts” and other amphetamine-type stimulants with amphetamine screening immunoassays , 2013, Clinical toxicology.

[170]  Elisabetta Bertol,et al.  A novel screening method for 64 new psychoactive substances and 5 amphetamines in blood by LC-MS/MS and application to real cases. , 2016, Journal of pharmaceutical and biomedical analysis.

[171]  Shana O Kelley,et al.  Electrochemical Methods for the Analysis of Clinically Relevant Biomolecules. , 2016, Chemical reviews.

[172]  Marc Parrilla,et al.  Wearable Electrochemical Sensors for the Monitoring and Screening of Drugs. , 2020, ACS sensors.

[173]  H. Maurer,et al.  Determination of amphetamine, methamphetamine and amphetamine-derived designer drugs or medicaments in blood and urine. , 1998, Journal of chromatography. B, Biomedical sciences and applications.

[174]  Y. Yagcı,et al.  Polypeptide with electroactive endgroups as sensing platform for the abused drug 'methamphetamine' by bioelectrochemical method. , 2016, Talanta.

[175]  Marc Parrilla,et al.  The opportunity of 6-monoacetylmorphine to selectively detect heroin at preanodized screen printed electrodes. , 2021, Talanta.

[176]  Hua Zhang,et al.  Nanomaterial-based aptamer sensors for analysis of illicit drugs and evaluation of drugs consumption for wastewater-based epidemiology , 2020, TrAC Trends in Analytical Chemistry.

[177]  A. Oliveira‐Brett,et al.  Electrochemical oxidation of amphetamine-like drugs and application to electroanalysis of ecstasy in human serum. , 2010, Bioelectrochemistry.

[178]  Marc Parrilla,et al.  Wearable potentiometric ion sensors , 2019, TrAC Trends in Analytical Chemistry.

[179]  Yu-Ying Chao,et al.  Using ambient mass spectrometry and LC–MS/MS for the rapid detection and identification of multiple illicit street drugs , 2018, Journal of food and drug analysis.

[180]  Serge Rudaz,et al.  Dispersive liquid-liquid microextraction combined with capillary electrophoresis and time-of-flight mass spectrometry for urine analysis. , 2013, Journal of pharmaceutical and biomedical analysis.

[181]  S. Fanali,et al.  Analysis of drugs of forensic interest with capillary zone electrophoresis/time‐of‐flight mass spectrometry based on the use of non‐volatile buffers , 2012, Electrophoresis.

[182]  R. Venkataramanan,et al.  Newly Emerging Drugs of Abuse and Their Detection Methods: An ACLPS Critical Review. , 2018, American journal of clinical pathology.

[183]  J. Legros,et al.  Selective monomethylation of primary amines with simple electrophiles. , 2014, Chemical Communications.

[184]  G. Demets,et al.  Developing electrodes chemically modified with cucurbit(6)uril to detect 3,4-methylenedioxymethamphetamine (MDMA) by voltammetry , 2014 .

[185]  K. L. Peters,et al.  Infrared and Raman screening of seized novel psychoactive substances: a large scale study of >200 samples. , 2016, The Analyst.

[186]  Archana Jain,et al.  Recent advances in applications of single-drop microextraction: a review. , 2011, Analytica chimica acta.

[187]  Katharina M. Rentsch,et al.  Knowing the unknown – State of the art of LCMS in toxicology , 2016 .

[188]  H. Pontes,et al.  Toxicity of amphetamines: an update , 2012, Archives of Toxicology.

[189]  Calum Morrison,et al.  Determination and long-term stability of twenty-nine cathinones and amphetamine-type stimulants (ATS) in urine using gas chromatography-mass spectrometry. , 2018, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[190]  Jerome P. Smith,et al.  Enhanced Performance of Methamphetamine Lateral Flow Cassettes Using an Electronic Lateral Flow Reader , 2015, Journal of occupational and environmental hygiene.

[191]  J. Tettey,et al.  United Nations Office on Drugs and Crime: Recommended methods for the Identification and Analysis of Synthetic Cannabinoid Receptor Agonists in Seized Materials , 2021, Forensic science international. Synergy.

[192]  D. Pan,et al.  Discrimination of Fluoroamphetamine Regioisomers by Raman Spectroscopy , 2016 .

[193]  Susana Campuzano,et al.  Electrochemical sensors based on magnetic molecularly imprinted polymers: A review. , 2017, Analytica chimica acta.

[194]  N. Mdege,et al.  Screening instruments for detecting illicit drug use/abuse that could be useful in general hospital wards: a systematic review. , 2011, Addictive behaviors.

[195]  D. Jasinski,et al.  Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man , 1971, Clinical pharmacology and therapeutics.

[196]  Richard E. Tontarski,et al.  Objective Method for Presumptive Field-Testing of Illicit Drug Possession Using Centrifugal Microdevices and Smartphone Analysis. , 2016, Analytical chemistry.

[197]  A. Smilde,et al.  Revealing hidden information in GC–MS spectra from isomeric drugs: Chemometrics based identification from 15 eV and 70 eV EI mass spectra , 2020, Forensic Chemistry.

[198]  P. Andersson,et al.  Methodologies for assessment of limit of detection and limit of identification using surface-enhanced Raman spectroscopy , 2015 .

[199]  Abdelhamid Errachid,et al.  Sensitive Potentiometric Determination of Amphetamine with an All-Solid-State Micro Ion-Selective Electrode , 2018 .

[200]  M. Ganjali,et al.  Ultra-trace detection of methamphetamine in biological samples using FFT-square wave voltammetry and nano-sized imprinted polymer/MWCNTs -modified electrode. , 2019, Talanta.

[201]  A. M. García-Campaña,et al.  Capillary electrophoresis for the analysis of drugs of abuse in biological specimens of forensic interest , 2012 .

[202]  A. Carta,et al.  Determination of amphetamine-derived designer drugs in human urine by SPE extraction and capillary electrophoresis with mass spectrometry detection. , 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[203]  L. Andersson,et al.  Molecularly imprinted polymer-sol-gel tablet toward micro-solid phase extraction: II. Determination of amphetamine in human urine samples by liquid chromatography-tandem mass spectrometry. , 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[204]  S. Cherkaoui,et al.  Simultaneous analysis of some amphetamine derivatives in urine by nonaqueous capillary electrophoresis coupled to electrospray ionization mass spectrometry. , 2000, Journal of chromatography. A.

[205]  P. Schoenmakers,et al.  Distinguishing drug isomers in the forensic laboratory: GC-VUV in addition to GC-MS for orthogonal selectivity and the use of library match scores as a new source of information. , 2019, Forensic science international.

[206]  M. Ostacher,et al.  Stimulants: Amphetamine, Cocaine, and Synthetic Cathinones , 2014 .

[207]  B. McCord,et al.  MDMA Electrochemical Determination and Behavior at Carbon Screen‐printed Electrodes: Cheap Tools for Forensic Applications , 2020 .

[208]  Z. Zdravkovski,et al.  Rapid and simple method for direct determination of several amphetamines in seized tablets by GC--FID. , 2005, Forensic science international.

[209]  Jing Liu,et al.  Portable kit for identification and detection of drugs in human urine using surface-enhanced Raman spectroscopy. , 2015, Analytical chemistry.

[210]  C. Moore,et al.  Analysis of Drugs in Oral Fluid Using LC-MS/MS. , 2018, Methods in molecular biology.

[211]  F. Tagliaro,et al.  Hair analysis for illicit drugs by using capillary zone electrophoresis-electrospray ionization-ion trap mass spectrometry. , 2007, Journal of chromatography. A.

[212]  E. Vuori,et al.  Performance of immunoassays in screening for opiates, cannabinoids and amphetamines in post-mortem blood. , 2003, Forensic science international.

[213]  A. Salomone,et al.  On‐site identification of psychoactive drugs by portable Raman spectroscopy during drug‐checking service in electronic music events , 2019, Drug and alcohol review.

[214]  David E. Williams.  Electrochemical sensors for environmental gas analysis , 2020 .

[215]  M. Thevis,et al.  Determination of 74 new psychoactive substances in serum using automated in-line solid-phase extraction-liquid chromatography-tandem mass spectrometry. , 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[216]  M. Roushani,et al.  A highly selective and sensitive cocaine aptasensor based on covalent attachment of the aptamer-functionalized AuNPs onto nanocomposite as the support platform. , 2015, Analytica chimica acta.

[217]  Luke Clark,et al.  Profile of Executive and Memory Function Associated with Amphetamine and Opiate Dependence , 2006, Neuropsychopharmacology.

[218]  J. Namieśnik,et al.  Application of gas chromatography–tandem mass spectrometry for the determination of amphetamine‐type stimulants in blood and urine , 2018, Journal of pharmaceutical and biomedical analysis.

[219]  A. Heeger,et al.  An electronic, aptamer-based small-molecule sensor for the rapid, label-free detection of cocaine in adulterated samples and biological fluids. , 2006, Journal of the American Chemical Society.

[220]  Landulfo Silveira,et al.  Raman spectroscopy in forensic analysis: identification of cocaine and other illegal drugs of abuse , 2016 .

[221]  D. Nutt,et al.  Amphetamine, past and present – a pharmacological and clinical perspective , 2013, Journal of psychopharmacology.

[222]  Joseph Wang.  Electrochemical glucose biosensors. , 2008, Chemical reviews.

[223]  L. Langman,et al.  Introduction to Drugs of Abuse , 2019, Critical Issues in Alcohol and Drugs of Abuse Testing.

[224]  Ž. D. Mijin,et al.  The use of a gold electrode for the determination of amphetamine derivatives and application to their analysis in human urine , 2013 .

[225]  J. Tytgat,et al.  The use of presumptive color tests for new psychoactive substances. , 2016, Drug testing and analysis.

[226]  Manel del Valle,et al.  Voltammetric Electronic Tongue for the Simultaneous Determination of Three Benzodiazepines , 2019, Sensors.

[227]  L. Murphy,et al.  Disposable screen printed sensor for the electrochemical detection of methamphetamine in undiluted saliva , 2016, Chemistry Central Journal.