Osteocyte Remodeling of the Perilacunar and Pericanalicular Matrix

With additional functions of osteocytes being identified, the concept that osteocytes are just “static lacunar‐dwelling cells” is no longer accepted. We reviewed most of the relevant literature on osteocyte's function in the direct remodeling of the perilucunar matrix, discussing the advantages and disadvantages. Special attention was paid to how the negative researchers argue about the “osteocytic osteolysis” principle, and how the positive side addressed the arguments. We also discussed the newly found data of osteocytic remodeling function from our group. With more biotechnology in hand, there is increased excitement in the prospect of now being able to answer the two important questions: do osteocytes have the capability to remove mineral from the perilacunar matrix and if so what are the molecular and cellular mechanisms? do osteocytes have the capability to deposit new mineral on the perilacunar matrix and if so what are the cellular and molecular mechanisms?

[1]  B. Nico,et al.  Osteoplastic activity of mature osteocytes evaluated by H-proline incorporation. , 1982, Basic and applied histochemistry.

[2]  J. Wergedal,et al.  Bone formation by osteocytes. , 1971, The American journal of physiology.

[3]  Jason R. Stubbs,et al.  Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D. , 2006, Journal of the American Society of Nephrology : JASN.

[4]  Daniel P Nicolella,et al.  Osteocyte lacunae tissue strain in cortical bone. , 2006, Journal of biomechanics.

[5]  R. Mercer,et al.  The role of osteocytes in bone resorption during lactation: morphometric observations. , 1985, Bone.

[6]  A. van der Plas,et al.  Characteristics and properties of osteocytes in culture , 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[7]  Parfitt Am,et al.  The cellular basis of bone turnover and bone loss: a rebuttal of the osteocytic resorption--bone flow theory. , 1977 .

[8]  A. Walser,et al.  Structure and functions of osteocytes in normal conditions and under the influence of parathyroid extract , 1968 .

[9]  L. Bélanger.  Osteocytic osteolysis , 2005, Calcified Tissue Research.

[10]  M. Bouxsein,et al.  Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes , 2008, PloS one.

[11]  C. Baud.  MORPHOLOGIE ET STRUCTURE INFRAMICROSCOPIQUE DES OSTÉOCYTES , 1962 .

[12]  B. B. Migicovsky,et al.  HISTOCHEMICAL EVIDENCE OF PROTEOLYSIS IN BONE: THE INFLUENCE OF PARATHORMONE , 1963 .

[13]  L. Bélanger,et al.  PARATHORMONE-INDUCED OSTEOLYSIS IN DOGS. A MICRORADIOGRAPHIC AND ALPHARADIOGRAPHIC SURVEY. , 1964, The Journal of bone and joint surgery. American volume.

[14]  E. Bonucci,et al.  Histochemical and electron microscope investigations on medullary bone , 1975, Cell and Tissue Research.

[15]  Xi Jiang,et al.  Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene. , 2004, Bone.

[16]  L. Bélanger,et al.  Technical approaches leading to the concept of osteocytic osteolysis. , 1967, Clinical orthopaedics and related research.

[17]  L. Bonewald,et al.  Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism , 2006, Nature Genetics.

[18]  L. Bonewald,et al.  Establishment of an Osteocyte‐like Cell Line, MLO‐Y4 , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[19]  Qing Chen,et al.  Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis , 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[20]  G. Marotti,et al.  Quantitative evaluation on osteocyte canalicular density in human secondary osteons. , 1995, Bone.

[21]  M. Balooch,et al.  Glucocorticoid‐Treated Mice Have Localized Changes in Trabecular Bone Material Properties and Osteocyte Lacunar Size That Are Not Observed in Placebo‐Treated or Estrogen‐Deficient Mice , 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[22]  C A Baud,et al.  Submicroscopic structure and functional aspects of the osteocyte. , 1968, Clinical orthopaedics and related research.

[23]  Y Wang,et al.  Effects of nanomechanical bone tissue properties on bone tissue strain: implications for osteocyte mechanotransduction. , 2008, Journal of musculoskeletal & neuronal interactions.

[24]  S. Toyosawa,et al.  Eccentric Localization of Osteocytes Expressing Enzymatic Activities, Protein, and mRNA Signals for Type 5 Tartrate-resistant Acid Phosphatase (TRAP) , 2004, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[25]  H. Donahue,et al.  Gap Junctions and Biophysical Regulation of Bone Cells , 2010, Clinical reviews in bone and mineral metabolism.

[26]  M. Zimny,et al.  Effects of Hibernation on Interradicular Alveolar Bone , 1977, Journal of dental research.

[27]  L. Bélanger,et al.  Osteolysis in the frog. The effects of parathormone. , 1966, Canadian Journal of Physiology and Pharmacology.

[28]  M. HELLER-STEINBERG,et al.  Ground substance, bone salts, and cellular activity in bone formation and destruction. , 1951, The American journal of anatomy.

[29]  F. Recklinghausen,et al.  Untersuchungen über Rachitis und Osteomalacie , 1910 .

[30]  E. Bonucci,et al.  Bone changes in hemodialyzed uremic subjects , 1976, Virchows Archiv A.

[31]  H. Jüppner,et al.  Receptors specific for the carboxyl-terminal region of parathyroid hormone on bone-derived cells: determinants of ligand binding and bioactivity. , 2005, Endocrinology.

[32]  C. Baud,et al.  Structural changes of the periosteocytic area inVipera aspis (L.) (Ophidia, viperidae) bone tissue in various physiological conditions , 2007, Calcified Tissue International.

[33]  E. B. Ruth.  Basophilic islands in osseous tissue and their relation to resorption , 1961, The Anatomical record.

[34]  A. Teti,et al.  Mature osteocytes behaviour in a repletion period: the occurrence of osteoplastic activity. , 1983, Basic and applied histochemistry.

[35]  H. Donahue,et al.  Gap junctions and biophysical regulation of bone cell differentiation. , 2000, Bone.

[36]  J. Wergedal,et al.  DISTRIBUTION OF ACID AND ALKALINE PHOSPHATASE ACTIVITY IN UNDEMINERALIZED SECTIONS OF THE RAT TIBIAL DIAPHYSIS , 1969, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[37]  A. Boyde,et al.  Estimation of the size of resorption lacunae in mammalian calcified tissues using SEM stereophotogrammetry. , 1979, Scanning electron microscopy.

[38]  A. Parfitt,et al.  The cellular basis of bone turnover and bone loss: a rebuttal of the osteocytic resorption--bone flow theory. , 1977, Clinical orthopaedics and related research.