Spontaneous resolution of cutaneous Langerhans cell histiocytosis in an infant

Langerhans cell histiocytosis (LCH) is a rare proliferative disorder, characterised by an accumulation of cells sharing the major phenotypic features of cutaneous Langerhans cells. Given its variable evolution, ranging from self-healing to multisystemic forms with poor prognosis, it is debated whether it is a neoplastic or an inflammatory disease [1]. Recent genomic data support a possible common origin of the disease in the bone marrow. Whole-exome sequencing revealed a high frequency of activating [...]

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