Bone Metastasis: Find Your Niche and Fit in.

[1]  Stephen T. C. Wong,et al.  The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability. , 2018, Cancer cell.

[2]  A. Speakman,et al.  Communication of prostate cancer cells with bone cells via extracellular vesicle RNA; a potential mechanism of metastasis , 2018, Oncogene.

[3]  A. Muthalib,et al.  Bone Metastasis in Advanced Breast Cancer: Analysis of Gene Expression Microarray , 2018, Clinical breast cancer.

[4]  C. Hudis,et al.  Phase II Study of Paclitaxel and Dasatinib in Metastatic Breast Cancer , 2018, Clinical Breast Cancer.

[5]  L. Tang,et al.  NPNT promotes early-stage bone metastases in breast cancer by regulation of the osteogenic niche , 2018, Journal of bone oncology.

[6]  Samuel E. Zimmerman,et al.  Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow , 2018, Nature Communications.

[7]  Yibin Kang,et al.  The Biology of Bone Metastasis. , 2018, Cold Spring Harbor perspectives in medicine.

[8]  I. Wistuba,et al.  Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFβRIII-p38MAPK-pS249/T252RB Pathway. , 2018, Cancer research.

[9]  Gustav Stålhammar,et al.  Evolutionary history of metastatic breast cancer reveals minimal seeding from axillary lymph nodes , 2018, The Journal of clinical investigation.

[10]  R. Gomis,et al.  MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer , 2018, Nature Cell Biology.

[11]  Catriona McLean,et al.  Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML , 2018, Cell stem cell.

[12]  J. Hong,et al.  Osteomacs interact with megakaryocytes and osteoblasts to regulate murine hematopoietic stem cell function. , 2017, Blood advances.

[13]  Yibin Kang,et al.  Therapeutic Antibody Targeting Tumor- and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to Chemotherapy. , 2017, Cancer cell.

[14]  Omar K. Yaghi,et al.  Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils , 2017, Science.

[15]  Elena Butturini,et al.  Metastatic Breast Cancer Cells Enter Into Dormant State and Express Cancer Stem Cells Phenotype Under Chronic Hypoxia , 2017, Journal of cellular biochemistry.

[16]  Aaron E. Chiou,et al.  Multiscale characterization of the mineral phase at skeletal sites of breast cancer metastasis , 2017, Proceedings of the National Academy of Sciences.

[17]  Shuiping Gao,et al.  Comparison of patterns and prognosis among distant metastatic breast cancer patients by age groups: a SEER population-based analysis , 2017, Scientific Reports.

[18]  O. Naveiras,et al.  Bone marrow adipocytes promote the regeneration of stem cells and hematopoiesis by secreting SCF , 2017, Nature Cell Biology.

[19]  Xiaoping Zhou,et al.  Endothelial-to-Osteoblast Conversion Generates Osteoblastic Metastasis of Prostate Cancer. , 2017, Developmental cell.

[20]  H. Takeyama,et al.  Usefulness of CTC and DTC-BM Detection for Adjuvant Therapy Effects and Prognosis Prediction in Early Breast Carcinoma: Results of 8–11 Years of Follow-up Evaluation , 2017, Annals of Surgical Oncology.

[21]  A. Mastro,et al.  Role of Megakaryocytes in Breast Cancer Metastasis to Bone. , 2017, Cancer research.

[22]  Thomas R. Cox,et al.  Pre-metastatic niches: organ-specific homes for metastases , 2017, Nature Reviews Cancer.

[23]  Nicolas F. Fernandez,et al.  Differential cytokine contributions of perivascular haematopoietic stem cell niches , 2017, Nature Cell Biology.

[24]  Rainer Spang,et al.  Early dissemination seeds metastasis in breast cancer , 2016, Nature.

[25]  J. Condeelis,et al.  Mechanism of early dissemination and metastasis in Her2+ mammary cancer , 2016, Nature.

[26]  S. Brooks,et al.  Breast cancer osteomimicry and its role in bone specific metastasis; an integrative, systematic review of preclinical evidence. , 2016, Breast.

[27]  Christopher A. Miller,et al.  Tumor Evolution in Two Patients with Basal-like Breast Cancer: A Retrospective Genomics Study of Multiple Metastases , 2016, PLoS medicine.

[28]  Younghun Jung,et al.  Axl is required for TGF-β2-induced dormancy of prostate cancer cells in the bone marrow , 2016, Scientific Reports.

[29]  D. Prockop,et al.  Cancer cells enter dormancy after cannibalizing mesenchymal stem/stromal cells (MSCs) , 2016, Proceedings of the National Academy of Sciences.

[30]  Steven J. Greco,et al.  Mesenchymal Stem Cell-Derived Exosomes Stimulate Cycling Quiescence and Early Breast Cancer Dormancy in Bone Marrow. , 2016, Cancer research.

[31]  K. Anderson,et al.  Osteoclasts promote immune suppressive microenvironment in multiple myeloma: therapeutic implication. , 2016, Blood.

[32]  O. Peyruchaud,et al.  Metastasis: new functional implications of platelets and megakaryocytes. , 2016, Blood.

[33]  C. McCall,et al.  Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone , 2016, Science Translational Medicine.

[34]  Charles P. Lin,et al.  Distinct bone marrow blood vessels differentially regulate hematopoiesis , 2016, Nature.

[35]  C. Edwards,et al.  The role of bone marrow adipocytes in bone metastasis , 2016, Journal of bone oncology.

[36]  Tae-Young Roh,et al.  CD82/KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages. , 2016, Cell stem cell.

[37]  Elisa de Stanchina,et al.  Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT , 2016, Cell.

[38]  C. D. Savci-Heijink,et al.  A novel gene expression signature for bone metastasis in breast carcinomas , 2016, Breast Cancer Research and Treatment.

[39]  J. Massagué,et al.  Metastatic colonization by circulating tumour cells , 2016, Nature.

[40]  W. Schiemann,et al.  Mesenchymal stem cells regulate melanoma cancer cells extravasation to bone and liver at their perivascular niche , 2016, International journal of cancer.

[41]  A. Zannettino,et al.  Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche , 2015, Nature Communications.

[42]  W. Maloney,et al.  Breast Cancer Cell Colonization of the Human Bone Marrow Adipose Tissue Niche1 , 2015, Neoplasia.

[43]  Gary K. Schwartz,et al.  Tumour exosome integrins determine organotropic metastasis , 2015, Nature.

[44]  K. Pienta,et al.  Bone marrow macrophages support prostate cancer growth in bone , 2015, Oncotarget.

[45]  J. Massagué,et al.  Surviving at a Distance: Organ-Specific Metastasis. , 2015, Trends in cancer.

[46]  S. Basu,et al.  Matrix rigidity regulates the transition of tumor cells to a bone-destructive phenotype through integrin β3 and TGF-β receptor type II. , 2015, Biomaterials.

[47]  Zhiyu Zhao,et al.  Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal , 2015, Nature.

[48]  R. Linding,et al.  The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase , 2015, Nature.

[49]  M. Nykter,et al.  The Evolutionary History of Lethal Metastatic Prostate Cancer , 2015, Nature.

[50]  Stephen T. C. Wong,et al.  The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells. , 2015, Cancer cell.

[51]  R. Greil,et al.  Zoledronic acid combined with adjuvant endocrine therapy of tamoxifen versus anastrozol plus ovarian function suppression in premenopausal early breast cancer: final analysis of the Austrian Breast and Colorectal Cancer Study Group Trial 12. , 2015, Annals of oncology : official journal of the European Society for Medical Oncology.

[52]  L. Zon,et al.  Hematopoietic Stem Cell Arrival Triggers Dynamic Remodeling of the Perivascular Niche , 2015, Cell.

[53]  G. Roodman,et al.  Acidic Extracellular Microenvironment in Myeloma-Colonized Bone Contributes to Bone Pain , 2014 .

[54]  I. Holen,et al.  Prostate Cancer Cells Preferentially Home to Osteoblast‐rich Areas in the Early Stages of Bone Metastasis: Evidence From In Vivo Models , 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[55]  K. Pantel,et al.  Bone marrow as a reservoir for disseminated tumor cells: a special source for liquid biopsy in cancer patients. , 2014, BoneKEy reports.

[56]  B. Naume,et al.  Clinical outcome with correlation to disseminated tumor cell (DTC) status after DTC-guided secondary adjuvant treatment with docetaxel in early breast cancer. , 2014, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[57]  J. Rivas,et al.  A gene signature of bone metastatic colonization sensitizes for tumor-induced osteolysis and predicts survival in lung cancer , 2014, Oncogene.

[58]  P. Bragado,et al.  Mechanisms of disseminated cancer cell dormancy: an awakening field , 2014, Nature Reviews Cancer.

[59]  S. Morrison,et al.  Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow. , 2014, Cell stem cell.

[60]  J. Charles,et al.  Osteoclasts: more than 'bone eaters'. , 2014, Trends in molecular medicine.

[61]  D. Cameron,et al.  Adjuvant zoledronic acid in patients with early breast cancer: final efficacy analysis of the AZURE (BIG 01/04) randomised open-label phase 3 trial. , 2014, The Lancet. Oncology.

[62]  G. Cline,et al.  Functional polarization of tumour-associated macrophages by tumour-derived lactic acid , 2014, Nature.

[63]  N. Kosaka,et al.  Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells , 2014, Science Signaling.

[64]  K. Junker,et al.  High calcium concentration in bones promotes bone metastasis in renal cell carcinomas expressing calcium-sensing receptor , 2014, Molecular Cancer.

[65]  A. Godwin,et al.  Bone sialoprotein and osteopontin in bone metastasis of osteotropic cancers. , 2014, Critical reviews in oncology/hematology.

[66]  S. Morrison,et al.  The bone marrow niche for haematopoietic stem cells , 2014, Nature.

[67]  A. Tutt,et al.  A novel model of dormancy for bone metastatic breast cancer cells. , 2013, Cancer research.

[68]  P. Bragado,et al.  TGFβ2 dictates disseminated tumour cell fate in target organs through TGFβ-RIII and p38α/β signalling , 2013, Nature Cell Biology.

[69]  A. Bergman,et al.  Arteriolar niches maintain haematopoietic stem cell quiescence , 2013, Nature.

[70]  K. Hess,et al.  Clinical relevance of cancer stem cells in bone marrow of early breast cancer patients. , 2013, Annals of oncology : official journal of the European Society for Medical Oncology.

[71]  J. Foekens,et al.  Selection of Bone Metastasis Seeds by Mesenchymal Signals in the Primary Tumor Stroma , 2013, Cell.

[72]  R. Azevedo,et al.  T Cells Induce Pre-Metastatic Osteolytic Disease and Help Bone Metastases Establishment in a Mouse Model of Metastatic Breast Cancer , 2013, PloS one.

[73]  I. Bruns,et al.  PDGFRα and CD51 mark human Nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion , 2013, The Journal of experimental medicine.

[74]  Mina J. Bissell,et al.  The perivascular niche regulates breast tumor dormancy , 2013, Nature Cell Biology.

[75]  F. Schuetz,et al.  Prognostic Value of Disseminated Tumor Cells in the Bone Marrow of Patients with Operable Primary Breast Cancer: A Long-term Follow-up Study , 2013, Annals of Surgical Oncology.

[76]  Zuozhang Yang,et al.  Genome-Wide Identification of Bone Metastasis-Related MicroRNAs in Lung Adenocarcinoma by High-Throughput Sequencing , 2013, PloS one.

[77]  P. Frenette,et al.  This niche is a maze; an amazing niche. , 2013, Cell stem cell.

[78]  A. Martner,et al.  Myeloid-Derived Suppressor Cells Regulate Growth of Multiple Myeloma by Inhibiting T Cells in Bone Marrow , 2013, The Journal of Immunology.

[79]  J. Forbes,et al.  Zoledronic acid (zoledronate) for postmenopausal women with early breast cancer receiving adjuvant letrozole (ZO-FAST study): final 60-month results. , 2013 .

[80]  S. Ponnazhagan,et al.  Myeloid-derived suppressor cells function as novel osteoclast progenitors enhancing bone loss in breast cancer. , 2013, Cancer research.

[81]  S. Morrison,et al.  Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches , 2013, Nature.

[82]  A. Weiss,et al.  Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function. , 2012, The Journal of clinical investigation.

[83]  D. Link,et al.  CXCL12 Production by Early Mesenchymal Progenitors is Required for Hematopoietic Stem Cell Maintenance , 2012, Nature.

[84]  G. Mundy,et al.  Osteoclasts in Multiple Myeloma Are Derived from Gr-1+CD11b+Myeloid-Derived Suppressor Cells , 2012, PloS one.

[85]  G. Siegal,et al.  Depletion of Plasmacytoid Dendritic Cells Inhibits Tumor Growth and Prevents Bone Metastasis of Breast Cancer Cells , 2012, The Journal of Immunology.

[86]  M. Gnant,et al.  The impact of menopause on bone, zoledronic acid, and implications for breast cancer growth and metastasis. , 2012 .

[87]  J. Lévesque,et al.  Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance , 2012, Nature Medicine.

[88]  A. Mildner,et al.  Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow , 2012, Nature Immunology.

[89]  A. Brivanlou,et al.  The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites , 2012, Cell.

[90]  Paul J Hertzog,et al.  Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape , 2012, Nature Medicine.

[91]  Gema Moreno-Bueno,et al.  Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET , 2012, Nature Medicine.

[92]  E. Sitnicka,et al.  Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow , 2012, The Journal of experimental medicine.

[93]  T. Sparwasser,et al.  Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer , 2012, Oncoimmunology.

[94]  X. Pei,et al.  Mesenchymal stem cells from primary breast cancer tissue promote cancer proliferation and enhance mammosphere formation partially via EGF/EGFR/Akt pathway , 2012, Breast Cancer Research and Treatment.

[95]  S. Casimiro,et al.  Analysis of a bone metastasis gene expression signature in patients with bone metastasis from solid tumors , 2012, Clinical & Experimental Metastasis.

[96]  F. Lecanda,et al.  Inhibition of Collagen Receptor Discoidin Domain Receptor-1 (DDR1) Reduces Cell Survival, Homing, and Colonization in Lung Cancer Bone Metastasis , 2012, Clinical Cancer Research.

[97]  Lei Ding,et al.  Endothelial and perivascular cells maintain haematopoietic stem cells , 2011, Nature.

[98]  J. Massagué,et al.  VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors. , 2011, Cancer cell.

[99]  D. Link,et al.  N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells. , 2011, Blood.

[100]  Huanbin Xu,et al.  Bone marrow and the control of immunity , 2011, Cellular and Molecular Immunology.

[101]  W. Gregory,et al.  Breast-cancer adjuvant therapy with zoledronic acid. , 2011, The New England journal of medicine.

[102]  K. Blackwell,et al.  Phase II Trial of Dasatinib in Patients with Metastatic Breast Cancer Using Real-Time Pharmacodynamic Tissue Biomarkers of Src Inhibition to Escalate Dosing , 2011, Clinical Cancer Research.

[103]  D. Piwnica-Worms,et al.  CD8+ T cells regulate bone tumor burden independent of osteoclast resorption. , 2011, Cancer research.

[104]  R. Greil,et al.  Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial. , 2011, The Lancet. Oncology.

[105]  T. Guise,et al.  Cancer to bone: a fatal attraction , 2011, Nature Reviews Cancer.

[106]  K. Pienta,et al.  Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow. , 2011, The Journal of clinical investigation.

[107]  T. Fehm,et al.  Persistence of Disseminated Tumor Cells in the Bone Marrow of Breast Cancer Patients Predicts Increased Risk for Relapse—A European Pooled Analysis , 2011, Clinical Cancer Research.

[108]  Steven J. Greco,et al.  Gap junction-mediated import of microRNA from bone marrow stromal cells can elicit cell cycle quiescence in breast cancer cells. , 2011, Cancer research.

[109]  M. Behmanesh,et al.  The detection of disseminated tumor cells in bone marrow and peripheral blood of gastric cancer patients by multimarker (CEA, CK20, TFF1 and MUC2) quantitative real-time PCR. , 2011, Clinical biochemistry.

[110]  Scott A. Guelcher,et al.  Matrix Rigidity Induces Osteolytic Gene Expression of Metastatic Breast Cancer Cells , 2010, PloS one.

[111]  P. Neven,et al.  Efficacy of zoledronic acid in postmenopausal women with early breast cancer receiving adjuvant letrozole: 36-month results of the ZO-FAST Study. , 2010, Annals of oncology : official journal of the European Society for Medical Oncology.

[112]  A. Sood,et al.  The sympathetic nervous system induces a metastatic switch in primary breast cancer. , 2010, Cancer research.

[113]  Ben D. MacArthur,et al.  Mesenchymal and haematopoietic stem cells form a unique bone marrow niche , 2010, Nature.

[114]  K. Pienta,et al.  Inhibitory Effects of Megakaryocytic Cells in Prostate Cancer Skeletal Metastasis , 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[115]  K. Vandyke,et al.  The tyrosine kinase inhibitor dasatinib dysregulates bone remodeling through inhibition of osteoclasts in vivo , 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[116]  Karen Gelmon,et al.  Metastatic behavior of breast cancer subtypes. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[117]  M. Piccart,et al.  The Src inhibitor dasatinib accelerates the differentiation of human bone marrow-derived mesenchymal stromal cells into osteoblasts , 2010, BMC Cancer.

[118]  Ian A. White,et al.  Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. , 2010, Cell stem cell.

[119]  Hans Clevers,et al.  Coexistence of Quiescent and Active Adult Stem Cells in Mammals , 2010, Science.

[120]  C. Fischbach,et al.  A Novel 3-D Mineralized Tumor Model to Study Breast Cancer Bone Metastasis , 2010, PloS one.

[121]  Matthew J. Craig,et al.  CCL2 and Interleukin-6 Promote Survival of Human CD11b+ Peripheral Blood Mononuclear Cells and Induce M2-type Macrophage Polarization* , 2009, The Journal of Biological Chemistry.

[122]  P. Musiani,et al.  Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway , 2009, Journal of cellular and molecular medicine.

[123]  Michael P. Sheetz,et al.  Differential Matrix Rigidity Response in Breast Cancer Cell Lines Correlates with the Tissue Tropism , 2009, PloS one.

[124]  C. Boudot,et al.  Extracellular calcium promotes the migration of breast cancer cells through the activation of the calcium sensing receptor. , 2009, Experimental cell research.

[125]  Larry Norton,et al.  Latent bone metastasis in breast cancer tied to Src-dependent survival signals. , 2009, Cancer cell.

[126]  Thomas J Mitchell,et al.  Src Family Kinase Activity Is Up-Regulated in Hormone-Refractory Prostate Cancer , 2009, Clinical Cancer Research.

[127]  T. Fehm,et al.  Disseminated Tumor Cells in Bone Marrow May Affect Prognosis of Patients With Gynecologic Malignancies , 2009, International Journal of Gynecologic Cancer.

[128]  S. Morrison,et al.  Hematopoietic stem cells do not depend on N-cadherin to regulate their maintenance. , 2009, Cell stem cell.

[129]  C. Shao,et al.  Human mesenchymal stem cells inhibit cancer cell proliferation by secreting DKK-1 , 2009, Leukemia.

[130]  N. Ibrahim,et al.  Phase II trial of dasatinib in triple-negative breast cancer: results of study CA180059. , 2009 .

[131]  J. Köllermann,et al.  Prognostic significance of disseminated tumor cells in the bone marrow of prostate cancer patients treated with neoadjuvant hormone treatment. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[132]  Michelle Collazo,et al.  Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice1 , 2008, The Journal of Immunology.

[133]  S. Badylak,et al.  A perivascular origin for mesenchymal stem cells in multiple human organs. , 2008, Cell stem cell.

[134]  K. Packman,et al.  Mesenchymal Stem Cells in Early Entry of Breast Cancer into Bone Marrow , 2008, PloS one.

[135]  J. Thiery,et al.  Disseminated Tumor Cells of Breast Cancer Patients: A Strong Prognostic Factor for Distant and Local Relapse , 2008, Clinical Cancer Research.

[136]  R. Eils,et al.  Systemic spread is an early step in breast cancer. , 2008, Cancer cell.

[137]  A. Cope,et al.  Treg cells suppress osteoclast formation: a new link between the immune system and bone. , 2007, Arthritis and rheumatism.

[138]  J. Aguirre-Ghiso,et al.  Models, mechanisms and clinical evidence for cancer dormancy , 2007, Nature Reviews Cancer.

[139]  J. Chirgwin,et al.  Molecular Biology of Bone Metastasis , 2007, Molecular Cancer Therapeutics.

[140]  E. Morgan,et al.  Disruption of CXCR4 enhances osteoclastogenesis and tumor growth in bone , 2007, Proceedings of the National Academy of Sciences.

[141]  S. Morrison,et al.  Lack of evidence that hematopoietic stem cells depend on N-cadherin-mediated adhesion to osteoblasts for their maintenance. , 2007, Cell stem cell.

[142]  T. Yoneda,et al.  Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer. , 2007, Cancer research.

[143]  M. Rogers,et al.  Molecular Mechanisms of Action of Bisphosphonates: Current Status , 2006, Clinical Cancer Research.

[144]  R. Coleman.  Clinical Features of Metastatic Bone Disease and Risk of Skeletal Morbidity , 2006, Clinical Cancer Research.

[145]  A. Giuliano,et al.  Most Early Disseminated Cancer Cells Detected in Bone Marrow of Breast Cancer Patients Have a Putative Breast Cancer Stem Cell Phenotype , 2006, Clinical Cancer Research.

[146]  A. Schneider,et al.  Extracellular calcium as a candidate mediator of prostate cancer skeletal metastasis. , 2006, Cancer research.

[147]  Yongchang Chen,et al.  Mesenchymal stem cells derived from bone marrow favor tumor cell growth in vivo. , 2006, Experimental and molecular pathology.

[148]  Yi Zhang,et al.  Genes associated with breast cancer metastatic to bone. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[149]  T. Fehm,et al.  A pooled analysis of bone marrow micrometastasis in breast cancer. , 2005, The New England journal of medicine.

[150]  S. Morrison,et al.  Supplemental Experimental Procedures , 2022 .

[151]  Xunbin Wei,et al.  In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment , 2005, Nature.

[152]  P. Clézardin,et al.  Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer. , 2004, The Journal of clinical investigation.

[153]  A. Zallone,et al.  T cells support osteoclastogenesis in an in vitro model derived from human multiple myeloma bone disease: the role of the OPG/TRAIL interaction. , 2004, Blood.

[154]  Keisuke Ito,et al.  Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche , 2004, Cell.

[155]  W. Ma,et al.  Bone sialoprotein promotes bone metastasis of a non-bone-seeking clone of human breast cancer cells. , 2004, Anticancer research.

[156]  E. Keller,et al.  Prostate cancer bone metastases promote both osteolytic and osteoblastic activity , 2004, Journal of cellular biochemistry.

[157]  M. Tomasson,et al.  Platelet and osteoclast β3 integrins are critical for bone metastasis , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[158]  D. Scadden,et al.  Osteoblastic cells regulate the haematopoietic stem cell niche , 2003, Nature.

[159]  Haiyang Huang,et al.  Identification of the haematopoietic stem cell niche and control of the niche size , 2003, Nature.

[160]  G Kvalheim,et al.  Detection of isolated tumor cells in bone marrow is an independent prognostic factor in breast cancer. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[161]  C. Cordon-Cardo,et al.  A multigenic program mediating breast cancer metastasis to bone. , 2003, Cancer cell.

[162]  I. Fidler,et al.  The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited , 2003, Nature Reviews Cancer.

[163]  Y. Jung,et al.  Clinical significance of bone marrow micrometastasis detected by nested rt-PCR for keratin-19 in breast cancer patients. , 2003, Japanese journal of clinical oncology.

[164]  Chi-Wai Wong,et al.  Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[165]  N. Kieffer,et al.  Integrin αvβ3 expression confers on tumor cells a greater propensity to metastasize to bone , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[166]  G. Mundy.  Metastasis: Metastasis to bone: causes, consequences and therapeutic opportunities , 2002, Nature Reviews Cancer.

[167]  Evan T Keller,et al.  Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. , 2002, Cancer research.

[168]  D. G. Osmond,et al.  Basement membrane of mouse bone marrow sinusoids shows distinctive structure and proteoglycan composition: A high resolution ultrastructural study , 2001, The Anatomical record.

[169]  M. Morgan,et al.  Calcium hydroxyapatite promotes mitogenesis and matrix metalloproteinase expression in human breast cancer cell lines , 2001, Molecular carcinogenesis.

[170]  D. Feldman,et al.  The development of androgen-independent prostate cancer , 2001, Nature Reviews Cancer.

[171]  G. Bastert,et al.  Enrichment of memory T cells and other profound immunological changes in the bone marrow from untreated breast cancer patients , 2001, International journal of cancer.

[172]  E. Brown,et al.  Extracellular calcium-sensing receptor expression and its potential role in regulating parathyroid hormone-related peptide secretion in human breast cancer cell lines. , 2000, Endocrinology.

[173]  R. Gamagami,et al.  An orthotopic mouse model of remetastasis of human colon cancer liver metastasis. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

[174]  H. Moch,et al.  Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients. , 2000, Human pathology.

[175]  D A Hilton,et al.  Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. , 1999, Cancer research.

[176]  L. Chung,et al.  Osteomimetic properties of prostate cancer cells: A hypothesis supporting the predilection of prostate cancer metastasis and growth in the bone environment , 1999, The Prostate.

[177]  R Wieser,et al.  TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. , 1999, The Journal of clinical investigation.

[178]  S. Gillies,et al.  Natural Killer Cell–Mediated Eradication of Neuroblastoma Metastases to Bone Marrow by Targeted Interleukin-2 Therapy , 1998 .

[179]  K. Pienta,et al.  Preferential adhesion of prostate cancer cells to a human bone marrow endothelial cell line. , 1998, Journal of the National Cancer Institute.

[180]  S. Nilsson,et al.  Potential and distribution of transplanted hematopoietic stem cells in a nonablated mouse model. , 1997, Blood.

[181]  G. Hortobagyi,et al.  Long-term follow-up of patients with complete remission following combination chemotherapy for metastatic breast cancer. , 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[182]  M. Neumaier,et al.  Immunocytological detection of micrometastatic cells: Comparative evaluation of findings in the peritoneal cavity and the bone marrow of gastric, colorectal and pancreatic cancer patients , 1994, International journal of cancer.

[183]  G. Passeri,et al.  Interleukin-11: a new cytokine critical for osteoclast development. , 1994, The Journal of clinical investigation.

[184]  D. Bushinsky,et al.  Acidosis inhibits osteoblastic and stimulates osteoclastic activity in vitro. , 1992, The American journal of physiology.

[185]  J. Hainsworth,et al.  Metastatic breast cancer confined to the skeletal system: An indolent disease☆ , 1986 .

[186]  Yeu‐Tsu N. Lee,et al.  Breast carcinoma: Pattern of metastasis at autopsy , 1983, Journal of surgical oncology.

[187]  A. Ketcham,et al.  Metastasis of metastases. , 1975, American journal of surgery.

[188]  F. Jakob,et al.  A Subpopulation of Stromal Cells Controls Cancer Cell Homing to the Bone Marrow. , 2018, Cancer research.

[189]  T. Guise,et al.  TGF-β in cancer and bone: implications for treatment of bone metastases. , 2011, Bone.

[190]  C. Agrati,et al.  In vivo effects of zoledronic acid on peripheral γδ T lymphocytes in early breast cancer patients , 2008, Cancer Immunology and Immunotherapy.

[191]  C. Logothetis,et al.  Osteoblasts in prostate cancer metastasis to bone , 2005, Nature Reviews Cancer.

[192]  M. Karin,et al.  Potentiation of estrogen receptor activation function 1 (AF-1) by Src/JNK through a serine 118-independent pathway. , 2001, Molecular endocrinology.