Breast-Conserving Therapy for Breast Cancer: Targets for Investigation to Improve Results

Molecular characteristics of breast tumors are linked to their clinical behavior, with estrogen and progesterone receptor (ER/PR) expressing tumors, showing a less aggressive pattern of growth and metastasis, while ER/PR negative tumors behave in a more aggressive biologic fashion [1]. Expression of the EGF receptor-like moiety HER2-neu is also associated with adverse clinical behavior. The definition of tumor molecular signatures and clinical phenotype is undergoing redefinition with the description of luminal and basal-like categories [2]. Characteristic clinical behaviors and responsiveness to hormonal and chemotherapeutic definitions is predictable based on these features and continued definition of molecular targets for therapy is an important ongoing area of investigation. As the molecular pathways that govern tumor initiation, growth and metastasis are defined, it is certain that new effective targeted therapies will be developed to fundamentally direct our methods for treating breast cancer.

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