Visual short-term memory deficits in REM sleep behaviour disorder mirror those in Parkinson’s disease

Individuals with REM sleep behaviour disorder (RBD) are at high risk of Parkinson’s disease. Rolinski, Zokaei et al. show that they also display the same pattern of visual short-term memory deficits as patients with Parkinson’s disease, and suggest that this ‘fingerprint’ of memory impairment could be a prodromal disease marker.

[1]  B. Boeve REM sleep behavior disorder , 2010, Annals of the New York Academy of Sciences.

[2]  S. Cappa,et al.  Neuropsychological assessment in idiopathic REM sleep behavior disorder (RBD) , 2004, Neurology.

[3]  Paul M Bays,et al.  The precision of visual working memory is set by allocation of a shared resource. , 2009, Journal of vision.

[4]  P. Goldman-Rakic,et al.  D1 dopamine receptors in prefrontal cortex: involvement in working memory , 1991, Science.

[5]  Carlos H Schenck,et al.  Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series. , 2013, Sleep medicine.

[6]  M. Hasselmo,et al.  Modes and Models of Forebrain Cholinergic Neuromodulation of Cognition , 2011, Neuropsychopharmacology.

[7]  Wendy J Adams,et al.  Highlights, disparity, and perceived gloss with convex and concave surfaces. , 2013, Journal of vision.

[8]  Nikos Gorgoraptis,et al.  Working memory recall precision is a more sensitive index than span. , 2015, Journal of neuropsychology.

[9]  R. Postuma,et al.  Markers of neurodegeneration in idiopathic rapid eye movement sleep behaviour disorder and Parkinson's disease. , 2009, Brain : a journal of neurology.

[10]  M. Vendette,et al.  Executive dysfunction and memory impairment in idiopathic REM sleep behavior disorder , 2008, Neurology.

[11]  Timothy F. Brady,et al.  Modeling visual working memory with the MemToolbox. , 2013, Journal of vision.

[12]  Angie A. Kehagia,et al.  Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson's disease , 2010, The Lancet Neurology.

[13]  T Revesz,et al.  A clinico-pathological study of subtypes in Parkinson's disease. , 2009, Brain : a journal of neurology.

[14]  Ipek Oruc,et al.  Improved face discrimination after face adaptation , 2009 .

[15]  J. Hughes,et al.  Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. , 1992, Journal of neurology, neurosurgery, and psychiatry.

[16]  S. Cappa,et al.  Longitudinal study of cognitive function in idiopathic REM sleep behavior disorder. , 2011, Sleep.

[17]  Christos Proukakis,et al.  Visual short-term memory deficits associated with GBA mutation and Parkinson’s disease , 2014, Brain : a journal of neurology.

[18]  J. Heinrich,et al.  The C105fs114X Is the Prevalent Thyrotropin Beta-Subunit Gene Mutation in Argentinean Patients with Congenital Central Hypothyroidism , 2004, Hormone Research in Paediatrics.

[19]  Jacques Montplaisir,et al.  Polysomnographic features of REM sleep behavior disorder , 1992, Neurology.

[20]  Simona Luzzi,et al.  Short-term memory binding deficits in Alzheimer's disease. , 2008, Brain : a journal of neurology.

[21]  Yoav Ben-Shlomo,et al.  REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson's disease , 2013, Journal of Neurology, Neurosurgery & Psychiatry.

[22]  R. Postuma,et al.  Parkinson risk in idiopathic REM sleep behavior disorder , 2015, Neurology.

[23]  V. Sossi,et al.  Cholinergic and striatal dopaminergic dysfunction using pet as a risk marker for developing a neurodegenerative disease in patients with idiopathic rapid eye movement sleep behaviour disorder , 2013 .

[24]  R. Postuma,et al.  Rapid eye movement sleep behavior disorder and risk of dementia in Parkinson's disease: A prospective study , 2012, Movement disorders : official journal of the Movement Disorder Society.

[25]  E. Sinforiani,et al.  Cognitive performance in REM sleep behaviour disorder: a possible early marker of neurodegenerative disease? , 2008, Sleep medicine.

[26]  A. Singleton,et al.  Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease. , 2009, Brain : a journal of neurology.

[27]  V. Pankratz,et al.  Probable rapid eye movement sleep behavior disorder increases risk for mild cognitive impairment and Parkinson disease: A population‐based study , 2012, Annals of neurology.

[28]  J. Stockman Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease , 2011 .

[29]  Robert J Summers,et al.  Neuronal convergence in early contrast vision: binocular summation is followed by response nonlinearity and area summation. , 2009, Journal of vision.

[30]  J. Seamans,et al.  Dopamine Modulates Persistent Synaptic Activity and Enhances the Signal-to-Noise Ratio in the Prefrontal Cortex , 2009, PloS one.

[31]  Jonathan M. Schott,et al.  Binding deficits in memory following medial temporal lobe damage in patients with voltage-gated potassium channel complex antibody-associated limbic encephalitis , 2013, Brain : a journal of neurology.

[32]  W. Poewe,et al.  Defining at‐risk populations for Parkinson's disease: Lessons from ongoing studies , 2012, Movement disorders : official journal of the Movement Disorder Society.

[33]  W. Ma,et al.  Changing concepts of working memory , 2014, Nature Neuroscience.