Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.

The two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues.

[1]  J. Luban,et al.  A Dual Task for the Xbp1-responsive OS-9 Variants in the Mammalian Endoplasmic Reticulum , 2008, Journal of Biological Chemistry.

[2]  Jung‐Ja P. Kim,et al.  Structural Insights into the Mechanism of pH-dependent Ligand Binding and Release by the Cation-dependent Mannose 6-Phosphate Receptor* , 2008, Journal of Biological Chemistry.

[3]  M. Hulett,et al.  Cell Surface-expressed Cation-independent Mannose 6-Phosphate Receptor (CD222) Binds Enzymatically Active Heparanase Independently of Mannose 6-Phosphate to Promote Extracellular Matrix Degradation* , 2008, Journal of Biological Chemistry.

[4]  T. Shaler,et al.  OS-9 and GRP94 deliver mutant α1-antitrypsin to the Hrd1–SEL1L ubiquitin ligase complex for ERAD , 2008, Nature Cell Biology.

[5]  J. Wallace,et al.  Structure and functional analysis of the IGF‐II/IGF2R interaction , 2008, The EMBO journal.

[6]  D. Sleat,et al.  Proteomics Analysis of Serum from Mutant Mice Reveals Lysosomal Proteins Selectively Transported by Each of the Two Mannose 6-Phosphate Receptors*S , 2008, Molecular & Cellular Proteomics.

[7]  M. Gary‐Bobo,et al.  Mannose 6-phosphate receptor targeting and its applications in human diseases. , 2007, Current medicinal chemistry.

[8]  N. Dahms,et al.  Domain 5 of the cation-independent mannose 6-phosphate receptor preferentially binds phosphodiesters (mannose 6-phosphate N-acetylglucosamine ester). , 2007, Biochemistry.

[9]  P. Vogel,et al.  Murine UDP-GlcNAc:Lysosomal Enzyme N-Acetylglucosamine-1-phosphotransferase Lacking the γ-Subunit Retains Substantial Activity toward Acid Hydrolases* , 2007, Journal of Biological Chemistry.

[10]  C. V. Jongeneel,et al.  The M-Coffee web server: a meta-method for computing multiple sequence alignments by combining alternative alignment methods , 2007, Nucleic Acids Res..

[11]  A. Hasilik,et al.  The cation‐independent mannose 6‐phosphate receptor is involved in lysosomal delivery of serglycin , 2007, Journal of leukocyte biology.

[12]  D. Sleat,et al.  The human urine mannose 6-phosphate glycoproteome. , 2007, Biochimica et biophysica acta.

[13]  C. Morales,et al.  The sorting and trafficking of lysosomal proteins. , 2006, Histology and histopathology.

[14]  C. Cruciat,et al.  The MRH Protein Erlectin Is a Member of the Endoplasmic Reticulum Synexpression Group and Functions in N-Glycan Recognition* , 2006, Journal of Biological Chemistry.

[15]  Iain M. Wallace,et al.  M-Coffee: combining multiple sequence alignment methods with T-Coffee , 2006, Nucleic acids research.

[16]  W. Canfield,et al.  Mucolipidosis II (I-cell disease) and mucolipidosis IIIA (classical pseudo-hurler polydystrophy) are caused by mutations in the GlcNAc-phosphotransferase alpha / beta -subunits precursor gene. , 2006, American journal of human genetics.

[17]  Atul Mehta,et al.  Lysosomal Storage Disorders , 2005 .

[18]  R. Brady.  Enzyme replacement for lysosomal diseases. , 2006, Annual review of medicine.

[19]  C. Czupalla,et al.  Proteomic Analysis of Lysosomal Acid Hydrolases Secreted by Osteoclasts , 2006, Molecular & Cellular Proteomics.

[20]  R. Jirtle,et al.  Mannose 6-phosphate receptors in an ancient vertebrate, zebrafish , 2006, Development Genes and Evolution.

[21]  Hongtao Zhao,et al.  Identification of residues essential for carbohydrate recognition and cation dependence of the 46-kDa mannose 6-phosphate receptor. , 2005, Glycobiology.

[22]  S. Kornfeld,et al.  Identification of the Minimal Lysosomal Enzyme Recognition Domain in Cathepsin D* , 2005, Journal of Biological Chemistry.

[23]  J. Weissman,et al.  Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen. , 2005, Molecular cell.

[24]  Woong Kim,et al.  Yos9p detects and targets misfolded glycoproteins for ER-associated degradation. , 2005, Molecular cell.

[25]  M. Nita-Lazar,et al.  Yos9 protein is essential for degradation of misfolded glycoproteins and may function as lectin in ERAD. , 2005, Molecular cell.

[26]  C. Cromme,et al.  The Novel Drosophila Lysosomal Enzyme Receptor Protein Mediates Lysosomal Sorting in Mammalian Cells and Binds Mammalian and Drosophila GGA Adaptors* , 2005, Journal of Biological Chemistry.

[27]  Hong Li,et al.  The human brain mannose 6‐phosphate glycoproteome: A complex mixture composed of multiple isoforms of many soluble lysosomal proteins , 2005, Proteomics.

[28]  M. Gershon,et al.  Mannose 6-Phosphate Receptor Dependence of Varicella Zoster Virus Infection In Vitro and in the Epidermis during Varicella and Zoster , 2004, Cell.

[29]  S. Koduru,et al.  Biochemical and immunological characterization of a glycosylated alpha-fucosidase from the invertebrate Unio: interaction of the enzyme with its in vivo binding partners. , 2004, Protein expression and purification.

[30]  Sreelatha T. Reddy,et al.  Identification of a Low Affinity Mannose 6-Phosphate-binding Site in Domain 5 of the Cation-independent Mannose 6-Phosphate Receptor* , 2004, Journal of Biological Chemistry.

[31]  Jung‐Ja P. Kim,et al.  The N-terminal Carbohydrate Recognition Site of the Cation-independent Mannose 6-Phosphate Receptor* , 2004, Journal of Biological Chemistry.

[32]  Anthony H. Futerman,et al.  The cell biology of lysosomal storage disorders , 2004, Nature Reviews Molecular Cell Biology.

[33]  Jung‐Ja P. Kim,et al.  Structure of uPAR, plasminogen, and sugar‐binding sites of the 300 kDa mannose 6‐phosphate receptor , 2004, The EMBO journal.

[34]  C. Scriver,et al.  The Metabolic and Molecular Bases of Inherited Disease, 8th Edition 2001 , 2001, Journal of Inherited Metabolic Disease.

[35]  K. Figura,et al.  I-cell disease-like phenotype in mice deficient in mannose 6-phosphate receptors , 1998, Transgenic Research.

[36]  H. Freeze.  Modifications of lysosomal enzymes in Dictyostelium discoideum , 1986, Molecular and Cellular Biochemistry.

[37]  S. Kornfeld,et al.  The GGA proteins: key players in protein sorting at the trans-Golgi network. , 2004, European journal of cell biology.

[38]  J. Bonifacino.  The GGA proteins: adaptors on the move , 2004, Nature Reviews Molecular Cell Biology.

[39]  P. Meikle,et al.  Lysosomal storage disorders: emerging therapeutic options require early diagnosis , 2003, European Journal of Pediatrics.

[40]  P. Saftig,et al.  Deficiency of mannose 6‐phosphate receptors and lysosomal storage: a morphometric analysis of hepatocytes of neonatal mice , 2003, Cell biology international.

[41]  G. Gill,et al.  The secreted glycoprotein CREG inhibits cell growth dependent on the mannose-6-phosphate/insulin-like growth factor II receptor , 2003, Oncogene.

[42]  J. Byrd,et al.  Binding of Urokinase-type Plasminogen Activator Receptor (uPAR) to the Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor , 2003, Journal of Biological Chemistry.

[43]  S. Kornfeld,et al.  Mannose 6-phosphate receptors: new twists in the tale , 2003, Nature Reviews Molecular Cell Biology.

[44]  G. Sheldrick,et al.  Locating the anomalous scatterer substructures in halide and sulfur phasing. , 2003, Acta crystallographica. Section D, Biological crystallography.

[45]  M. Hancock,et al.  Localization of the Carbohydrate Recognition Sites of the Insulin-like Growth Factor II/Mannose 6-Phosphate Receptor to Domains 3 and 9 of the Extracytoplasmic Region* , 2002, The Journal of Biological Chemistry.

[46]  K. Figura,et al.  Identification of the putative mannose 6-phosphate receptor (MPR 46) protein in the invertebrate mollusc. , 2002 .

[47]  Craig J. Thalhauser,et al.  Role of N-Linked Oligosaccharide Flexibility in Mannose Phosphorylation of Lysosomal Enzyme Cathepsin L* , 2002, The Journal of Biological Chemistry.

[48]  V. Leksa,et al.  The N Terminus of Mannose 6-Phosphate/Insulin-like Growth Factor 2 Receptor in Regulation of Fibrinolysis and Cell Migration* , 2002, The Journal of Biological Chemistry.

[49]  M. Hancock,et al.  I-type lectins. , 2002 .

[50]  S. Kornfeld,et al.  Human Mannose 6-Phosphate-uncovering Enzyme Is Synthesized as a Proenzyme That Is Activated by the Endoprotease Furin* , 2002, The Journal of Biological Chemistry.

[51]  J. Garin,et al.  Proteomic analysis of human lysosomes: Application to monocytic and breast cancer cells , 2002, Proteomics.

[52]  M. Hancock,et al.  Identification of Residues Essential for Carbohydrate Recognition by the Insulin-like Growth Factor II/Mannose 6-Phosphate Receptor* , 2002, The Journal of Biological Chemistry.

[53]  Jung‐Ja P. Kim,et al.  Twists and Turns of the Cation-dependent Mannose 6-Phosphate Receptor , 2002, The Journal of Biological Chemistry.

[54]  R. Esnouf,et al.  Structure of a functional IGF2R fragment determined from the anomalous scattering of sulfur , 2002, The EMBO journal.

[55]  M. Hancock,et al.  P-type lectins. , 2002, Biochimica et biophysica acta.

[56]  K. von Figura,et al.  Identification of the Putative Mannose 6-Phosphate Receptor (MPR 46) Protein in the Invertebrate Mollusc , 2002, Bioscience reports.

[57]  G. Payne,et al.  Intracellular Cycling of Lysosomal Enzyme Receptors Cytoplasmic Tails' Tales , 2001, Cell.

[58]  S. Munro.  The MRH domain suggests a shared ancestry for the mannose 6-phosphate receptors and other N-glycan-recognising proteins , 2001, Current Biology.

[59]  S. Munro,et al.  A yeast homolog of the mammalian mannose 6-phosphate receptors contributes to the sorting of vacuolar hydrolases , 2001, Current Biology.

[60]  Jane Linnell,et al.  Real Time Kinetics of Insulin-like Growth Factor II (IGF-II) Interaction with the IGF-II/Mannose 6-Phosphate Receptor , 2001, The Journal of Biological Chemistry.

[61]  J. Rohrer,et al.  Lysosomal hydrolase mannose 6-phosphate uncovering enzyme resides in the trans-Golgi network. , 2001, Molecular biology of the cell.

[62]  K. Drickamer,et al.  Lectin-like proteins in model organisms: implications for evolution of carbohydrate-binding activity. , 2001, Glycobiology.

[63]  J. Bonifacino,et al.  The molecular machinery for lysosome biogenesis * , 2001, BioEssays : news and reviews in molecular, cellular and developmental biology.

[64]  J. Garin,et al.  Towards a human repertoire of monocytic lysosomal proteins , 2000, Electrophoresis.

[65]  S. Iwata,et al.  Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cell activation. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[66]  M. Hancock,et al.  Recognition of Dictyostelium discoideum lysosomal enzymes is conferred by the amino-terminal carbohydrate binding site of the insulin-like growth factor II/mannose 6-phosphate receptor. , 2000, Biochemistry.

[67]  S. Iwata,et al.  Internalization of CD 26 by mannose 6-phosphate y insulin-like growth factor II receptor contributes to T cell activation , 2000 .

[68]  M. Hancock,et al.  Mutational Analysis of the Binding Site Residues of the Bovine Cation-dependent Mannose 6-Phosphate Receptor* , 1999, The Journal of Biological Chemistry.

[69]  Jian Zhang,et al.  Structural Basis for Recognition of Phosphorylated High Mannose Oligosaccharides by the Cation-dependent Mannose 6-Phosphate Receptor* , 1999, The Journal of Biological Chemistry.

[70]  K. Drickamer.  C-type lectin-like domains. , 1999, Current opinion in structural biology.

[71]  K. von Figura,et al.  Identification of the Putative Mannose 6-phosphate Receptor Protein (MPR 300) in the Invertebrate unio , 1999, Bioscience reports.

[72]  B. Hoflack,et al.  Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor Mediates Internalization and Degradation of Leukemia Inhibitory Factor but Not Signal Transduction* , 1999, The Journal of Biological Chemistry.

[73]  J. Mottram,et al.  Protease Trafficking in Two Primitive Eukaryotes Is Mediated by a Prodomain Protein Motif* , 1999, The Journal of Biological Chemistry.

[74]  S. Godár,et al.  M6P/IGFII‐receptor complexes urokinase receptor and plasminogen for activation of transforming growth factor‐β1 , 1999 .

[75]  S. Godár,et al.  M6P/IGFII‐receptor complexes urokinase receptor and plasminogen for activation of transforming growth factor‐β1 , 1999 .

[76]  G. Devi,et al.  An insulin-like growth factor II (IGF-II) affinity-enhancing domain localized within extracytoplasmic repeat 13 of the IGF-II/mannose 6-phosphate receptor. , 1998, Molecular endocrinology.

[77]  B. Hoflack,et al.  Protein transport from the secretory to the endocytic pathway in mammalian cells. , 1998, Biochimica et biophysica acta.

[78]  J. Moreau,et al.  The Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor Is a Nanomolar Affinity Receptor for Glycosylated Human Leukemia Inhibitory Factor* , 1998, The Journal of Biological Chemistry.

[79]  D. Weix,et al.  Molecular Basis of Lysosomal Enzyme Recognition: Three-Dimensional Structure of the Cation-Dependent Mannose 6-Phosphate Receptor , 1998, Cell.

[80]  H. Vorum,et al.  Mannose 6-Phosphate/Insulin-like Growth Factor–II Receptor Targets the Urokinase Receptor to Lysosomes via a Novel Binding Interaction , 1998, The Journal of cell biology.

[81]  M. Yamada,et al.  Cloning and characterization of three isoforms of OS-9 cDNA and expression of the OS-9 gene in various human tumor cell lines. , 1998, Journal of biochemistry.

[82]  D. Sleat,et al.  Mouse mutants lacking the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor are impaired in lysosomal enzyme transport: comparison of cation-independent and cation-dependent mannose 6-phosphate receptor-deficient mice. , 1998, The Biochemical journal.

[83]  A. Leaf,et al.  Mannose-6-phosphate/insulin-like growth factor-II receptor is a receptor for retinoic acid. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[84]  A. Danser,et al.  Mannose 6-phosphate receptor-mediated internalization and activation of prorenin by cardiac cells. , 1997, Hypertension.

[85]  P. Breuer,et al.  Serine phosphorylation site of the 46-kDa mannose 6-phosphate receptor is required for transport to the plasma membrane in Madin-Darby canine kidney and mouse fibroblast cells. , 1997, Molecular biology of the cell.

[86]  D. Sleat,et al.  Ligand Binding Specificities of the Two Mannose 6-Phosphate Receptors* , 1997, The Journal of Biological Chemistry.

[87]  K. von Figura,et al.  Neither type of mannose 6-phosphate receptor is sufficient for targeting of lysosomal enzymes along intracellular routes , 1996, The Journal of cell biology.

[88]  T. Ludwig,et al.  Mouse mutants lacking the type 2 IGF receptor (IGF2R) are rescued from perinatal lethality in Igf2 and Igf1r null backgrounds. , 1996, Developmental biology.

[89]  H. Munier-Lehmann,et al.  Re-expression of the Mannose 6-Phosphate Receptors in Receptor-deficient Fibroblasts , 1996, The Journal of Biological Chemistry.

[90]  K. von Figura,et al.  The Two Mannose 6-Phosphate Receptors Transport Distinct Complements of Lysosomal Proteins (*) , 1995, The Journal of Biological Chemistry.

[91]  J. Rohrer,et al.  A determinant in the cytoplasmic tail of the cation-dependent mannose 6- phosphate receptor prevents trafficking to lysosomes , 1995, The Journal of cell biology.

[92]  C. Clayton,et al.  Protein trafficking in kinetoplastid protozoa. , 1995, Microbiological reviews.

[93]  K. von Figura,et al.  Localization of the Insulin-like Growth Factor II Binding Site to Amino Acids 1508–1566 in Repeat 11 of the Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor (*) , 1995, The Journal of Biological Chemistry.

[94]  H. Munier-Lehmann,et al.  Differential sorting of lysosomal enzymes in mannose 6‐phosphate receptor‐deficient fibroblasts. , 1994, The EMBO journal.

[95]  P. Aeed,et al.  Glycosylation of recombinant prorenin in insect cells: the insect cell line Sf9 does not express the mannose 6-phosphate recognition signal. , 1994, Biochemistry.

[96]  F. Masiarz,et al.  Herpes simplex virus glycoprotein D acquires mannose 6-phosphate residues and binds to mannose 6-phosphate receptors. , 1994, Journal of Biological Chemistry.

[97]  N. Dahms,et al.  The bovine mannose 6-phosphate/insulin-like growth factor II receptor. Localization of the insulin-like growth factor II binding site to domains 5-11. , 1994, The Journal of biological chemistry.

[98]  G. Griffiths,et al.  Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor , 1993, The Journal of cell biology.

[99]  B. Hoflack,et al.  Phosphorylation of the cation-independent mannose 6-phosphate receptor is closely associated with its exit from the trans-Golgi network , 1993, The Journal of cell biology.

[100]  T. Braulke,et al.  Role of protein phosphatases in insulin-like growth factor II (IGF II)-stimulated mannose 6-phosphate/IGF II receptor redistribution. , 1992, The Journal of biological chemistry.

[101]  S. Kornfeld,et al.  Characterization of the signal for rapid internalization of the bovine mannose 6-phosphate/insulin-like growth factor-II receptor. , 1992, The Journal of biological chemistry.

[102]  A. Udvardy,et al.  Purification of a lysosomal DNase from Drosophila melanogaster. , 1991, Biochemical and biophysical research communications.

[103]  O. Hindsgaul,et al.  The binding specificity of high and low molecular weight phosphomannosyl receptors from bovine testes. Inhibition studies with chemically synthesized 6-O-phosphorylated oligomannosides. , 1991, The Journal of biological chemistry.

[104]  H. Tomoda,et al.  Binding specificity of D-mannose 6-phosphate receptor of rabbit alveolar macrophages. , 1991, Carbohydrate research.

[105]  K. von Figura,et al.  Mutational analysis of disulfide bridges in the Mr 46,000 mannose 6-phosphate receptor. Localization and role for ligand binding. , 1991, The Journal of biological chemistry.

[106]  K. von Figura,et al.  Mr 46,000 mannose 6-phosphate receptor. The role of histidine and arginine residues for binding of ligand. , 1991, The Journal of biological chemistry.

[107]  D. Rifkin,et al.  Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[108]  E. Neufeld,et al.  Lysosomal storage diseases. , 1991, Annual review of biochemistry.

[109]  J. Grubb,et al.  The overexpressed human 46-kDa mannose 6-phosphate receptor mediates endocytosis and sorting of beta-glucuronidase. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[110]  S. Kornfeld,et al.  Lysosomal enzyme targeting. , 1990, Biochemical Society transactions.

[111]  D. Sherman,et al.  Varicella-zoster virus glycoprotein oligosaccharides are phosphorylated during posttranslational maturation , 1989, Journal of virology.

[112]  S. Kornfeld,et al.  Ligand interactions of the cation-independent mannose 6-phosphate receptor. The stoichiometry of mannose 6-phosphate binding. , 1989, The Journal of biological chemistry.

[113]  S. Kornfeld,et al.  Ligand interactions of the cation-dependent mannose 6-phosphate receptor. Comparison with the cation-independent mannose 6-phosphate receptor. , 1989, The Journal of biological chemistry.

[114]  A. Brunner,et al.  Identification of mannose 6-phosphate in two asparagine-linked sugar chains of recombinant transforming growth factor-beta 1 precursor. , 1988, The Journal of biological chemistry.

[115]  C. Gabel,et al.  Biosynthesis of the mannose 6-phosphate recognition marker in transport-impaired mouse lymphoma cells. Demonstration of a two-step phosphorylation. , 1988, The Journal of biological chemistry.

[116]  D. Nathans,et al.  Proliferin secreted by cultured cells binds to mannose 6-phosphate receptors. , 1988, The Journal of biological chemistry.

[117]  J. Chirgwin,et al.  Renin, a secretory glycoprotein, acquires phosphomannosyl residues , 1987, The Journal of cell biology.

[118]  H. Geuze,et al.  Mr 46,000 mannose 6‐phosphate specific receptor: its role in targeting of lysosomal enzymes. , 1987, The EMBO journal.

[119]  S. Kornfeld,et al.  The interaction of phosphorylated oligosaccharides and lysosomal enzymes with bovine liver cation-dependent mannose 6-phosphate receptor. , 1987, The Journal of biological chemistry.

[120]  R. Brady,et al.  Lysosomal Storage Diseases , 1986, The Lancet.

[121]  S. Kornfeld,et al.  Glycoprotein phosphorylation in simple eucaryotic organisms. Identification of UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase activity and analysis of substrate specificity. , 1986, The Journal of biological chemistry.

[122]  S. Kornfeld,et al.  Lysosomal enzyme binding to mouse P388D1 macrophage membranes lacking the 215-kDa mannose 6-phosphate receptor: evidence for the existence of a second mannose 6-phosphate receptor. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[123]  C. Gabel,et al.  Identification of methylphosphomannosyl residues as components of the high mannose oligosaccharides of Dictyostelium discoideum glycoproteins. , 1984, The Journal of biological chemistry.

[124]  K. von Figura,et al.  Biosynthesis and transport of lysosomal enzymes in human monocytes and macrophages. Effects of ammonium chloride, zymosan and tunicamycin. , 1983, The Biochemical journal.

[125]  A. Varki,et al.  Demonstration of the enzymatic mechanisms of α-N-acetyl-d-glucosamine-1-phosphodiester N-acetylglucosaminidase (formerly called α-N-acetylglucosaminylphosphodiesterase) and lysosomal α-N-acetylglucosaminidase , 1983 .

[126]  A. Varki,et al.  Demonstration of the enzymatic mechanisms of alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase (formerly called alpha-N-acetylglucosaminylphosphodiesterase) and lysosomal alpha-N-acetylglucosaminidase. , 1983, Archives of biochemistry and biophysics.

[127]  K. von Figura,et al.  UDP-N-acetylglucosamine:lysosomal enzyme precursor N-acetylglucosamine-1-phosphotransferase. Partial purification and characterization of the rat liver Golgi enzyme. , 1982, The Journal of biological chemistry.

[128]  K. von Figura,et al.  Synthesis of phosphorylated recognition marker in lysosomal enzymes is located in the cis part of Golgi apparatus. , 1982, The Journal of biological chemistry.

[129]  M. Reitman,et al.  Lysosomal enzyme targeting. N-Acetylglucosaminylphosphotransferase selectively phosphorylates native lysosomal enzymes. , 1981, The Journal of biological chemistry.

[130]  A. Varki,et al.  Purification and characterization of rat liver alpha-N-acetylglucosaminyl phosphodiesterase. , 1981, The Journal of biological chemistry.

[131]  K. von Figura,et al.  Processing of the phosphorylated recognition marker in lysosomal enzymes. Characterization and partial purification of a microsomal alpha-N-acetylglucosaminyl phosphodiesterase. , 1981, The Journal of biological chemistry.

[132]  K. von Figura,et al.  Phosphorylated oligosaccharides in lysosomal enzymes: identification of alpha-N-acetylglucosamine(1)phospho(6)mannose diester groups. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[133]  A. Varki,et al.  Structural studies of phosphorylated high mannose-type oligosaccharides. , 1980, The Journal of biological chemistry.

[134]  S. Kornfeld,et al.  Biosynthetic intermediates of beta-glucuronidase contain high mannose oligosaccharides with blocked phosphate residues. , 1980, The Journal of biological chemistry.

[135]  O. H. Lowry,et al.  Enzymatic identification of mannose 6-phosphate on the recognition marker for receptor-mediated pinocytosis of beta-glucuronidase by human fibroblasts. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[136]  G. Sahagian,et al.  Identification of mannose 6-phosphate in glycoproteins that inhibit the assimilation of beta-galactosidase by fibroblasts. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[137]  W. Sly,et al.  Phosphohexosyl components of a lysosomal enzyme are recognized by pinocytosis receptors on human fibroblasts. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[138]  E. Neufeld,et al.  A hypothesis for I-cell disease: defective hydrolases that do not enter lysosomes. , 1972, Biochemical and biophysical research communications.