University of Groningen Markers of fibroblast-rich tumor stroma and perivascular cells in serous ovarian cancer Corvigno,

Interand intra-patient variations in tumor microenvironment of serous ovarian cancer are largely unexplored. We aimed to explore potential co-regulation of tumor stroma characteristics, analyze their concordance in primary and metastatic lesions, and study their impact on survival. A tissue microarray (TMA) with 186 tumors and 91 matched metastases was subjected to immunohistochemistry double staining with endothelial cell marker CD34 and fibroblast and pericyte markers a-SMA, PDGFβR and desmin. Images were digitally analyzed to yield “metrics” related to vasculature and

[1]  G. Shapiro,et al.  Homologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian Cancer. , 2015, Cancer discovery.

[2]  M. Birrer,et al.  Calcium Dependent FAK/CREB/TNNC1 Signaling Mediates the Effect of Stromal MFAP5 on Ovarian Cancer Metastatic Potential , 2014, Nature Communications.

[3]  Umar Mahmood,et al.  Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. , 2014, Cancer cell.

[4]  Stephen A. Sastra,et al.  Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. , 2014, Cancer cell.

[5]  Janna Paulsson,et al.  Prognostic relevance of cancer-associated fibroblasts in human cancer. , 2014, Seminars in cancer biology.

[6]  Najeeb M. Halabi,et al.  Mesenchymal cell interaction with ovarian cancer cells induces a background dependent pro-metastatic transcriptomic profile , 2014, Journal of Translational Medicine.

[7]  Fiona M. Watt,et al.  Distinct fibroblast lineages determine dermal architecture in skin development and repair , 2013, Nature.

[8]  E. Sonnhammer,et al.  Prognostic significance in breast cancer of a gene signature capturing stromal PDGF signaling. , 2013, The American journal of pathology.

[9]  Benjamin Haibe-Kains,et al.  curatedOvarianData: clinically annotated data for the ovarian cancer transcriptome , 2013, Database J. Biol. Databases Curation.

[10]  T. Sjöblom,et al.  STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer. , 2013, Cancer research.

[11]  G. Eberl,et al.  Lineage tracing and genetic ablation of ADAM12+ perivascular cells identify a major source of profibrotic cells during acute tissue injury , 2012, Nature Medicine.

[12]  R. Ozols,et al.  Reclassification of serous ovarian carcinoma by a 2‐tier system , 2012, Cancer.

[13]  Zainab N. Khan,et al.  Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway. , 2012, Cancer cell.

[14]  Tatsuhiko Tsunoda,et al.  High-Risk Ovarian Cancer Based on 126-Gene Expression Signature Is Uniquely Characterized by Downregulation of Antigen Presentation Pathway , 2012, Clinical Cancer Research.

[15]  J. Mora,et al.  Identification of tumoral glial precursor cells in neuroblastoma. , 2011, Cancer letters.

[16]  R. Kalluri,et al.  Blockade of PDGF receptor signaling reduces myofibroblast number and attenuates renal fibrosis. , 2011, Kidney international.

[17]  D. Hanahan,et al.  Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression. , 2011, Blood.

[18]  S. H. van der Burg,et al.  Tumor-infiltrating Cytotoxic T Lymphocytes as Independent Prognostic Factor in Epithelial Ovarian Cancer With Wilms Tumor Protein 1 Overexpression , 2011, Journal of immunotherapy.

[19]  Benjamin J. Raphael,et al.  Integrated Genomic Analyses of Ovarian Carcinoma , 2011, Nature.

[20]  A. Sood,et al.  Cancer-associated fibroblasts and their putative role in potentiating the initiation and development of epithelial ovarian cancer. , 2011, Neoplasia.

[21]  Yuan Zhang,et al.  Ovarian cancer-associated fibroblasts contribute to epithelial ovarian carcinoma metastasis by promoting angiogenesis, lymphangiogenesis and tumor cell invasion. , 2011, Cancer Letters.

[22]  James O. Jones,et al.  Suppression of Antitumor Immunity by Stromal Cells Expressing , 2022 .

[23]  M. Nowak,et al.  Distant Metastasis Occurs Late during the Genetic Evolution of Pancreatic Cancer , 2010, Nature.

[24]  Andrew H. Beck,et al.  Variations in stromal signatures in breast and colorectal cancer metastases , 2010, The Journal of pathology.

[25]  P. Stattin,et al.  Stromal PDGFRβ Expression in Prostate Tumors and Non-Malignant Prostate Tissue Predicts Prostate Cancer Survival , 2010, PloS one.

[26]  Kristian Pietras,et al.  Hallmarks of cancer: interactions with the tumor stroma. , 2010, Experimental cell research.

[27]  D. Schadendorf,et al.  Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma , 2010, The Journal of Experimental Medicine.

[28]  M. Wei,et al.  CLIC4 mediates TGF-beta1-induced fibroblast-to-myofibroblast transdifferentiation in ovarian cancer. , 2009, Oncology reports.

[29]  C. Kuo,et al.  Cellular source and amount of vascular endothelial growth factor and platelet-derived growth factor in tumors determine response to angiogenesis inhibitors. , 2009, Cancer research.

[30]  C. Betsholtz,et al.  Endothelial-mural cell signaling in vascular development and angiogenesis. , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[31]  Yurii B. Shvetsov,et al.  Incidence of Ovarian, Peritoneal, and Fallopian Tube Carcinomas in the United States, 1995-2004 , 2009, Cancer Epidemiology Biomarkers & Prevention.

[32]  R. Tothill,et al.  Novel Molecular Subtypes of Serous and Endometrioid Ovarian Cancer Linked to Clinical Outcome , 2008, Clinical Cancer Research.

[33]  Johanna Andrae,et al.  Role of platelet-derived growth factors in physiology and medicine. , 2008, Genes & development.

[34]  K. Oktay,et al.  The Ovary , 2008, Annals of the New York Academy of Sciences.

[35]  Bin Tean Teh,et al.  Two Distinct Types of Blood Vessels in Clear Cell Renal Cell Carcinoma Have Contrasting Prognostic Implications , 2007, Clinical Cancer Research.

[36]  W. Cliby,et al.  Aggressive Surgical Effort and Improved Survival in Advanced-Stage Ovarian Cancer , 2006, Obstetrics and gynecology.

[37]  C. Enke,et al.  Effect of platelet-derived growth factor receptor-beta inhibition with STI571 on radioimmunotherapy. , 2005, Cancer research.

[38]  Kristian Pietras,et al.  A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[39]  Michael T Deavers,et al.  Grading Ovarian Serous Carcinoma Using a Two-Tier System , 2004, The American journal of surgical pathology.

[40]  Hys Ngan,et al.  Carcinoma of the Ovary , 2003, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

[41]  Holger Gerhardt,et al.  Endothelial-pericyte interactions in angiogenesis , 2003, Cell and Tissue Research.

[42]  Tobias Sjöblom,et al.  Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy. , 2002, Cancer research.

[43]  W. S. Lee,et al.  Effect of Bone Morphogenetic Protein-7 on Folliculogenesis and Ovulation in the Rat1 , 2001, Biology of reproduction.

[44]  D G Altman,et al.  A prognostic model for ovarian cancer , 2001, British Journal of Cancer.

[45]  C. Heldin,et al.  Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors. , 2001, Cancer research.

[46]  E. Keshet,et al.  A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. , 1998, Development.

[47]  C. Heldin,et al.  Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[48]  R. Arceci.  Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing , 2012 .

[49]  P. Cirri,et al.  Cancer associated fibroblasts: the dark side of the coin. , 2011, American journal of cancer research.

[50]  Yan Wu,et al.  Platelet-derived growth factor receptor-beta constitutive activity promotes angiogenesis in vivo and in vitro. , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[51]  W. Böcker.  [WHO classification of breast tumors and tumors of the female genital organs: pathology and genetics]. , 2002, Verhandlungen der Deutschen Gesellschaft fur Pathologie.

[52]  A. Skubitz,et al.  CD44 and beta1 integrin mediate ovarian carcinoma cell adhesion to peritoneal mesothelial cells. , 1999, The American journal of pathology.