Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene.

Insulin-like growth factor I (IGF-I) mediates the majority of the growth-promoting effects of growth hormone (GH) after birth.1 In the prenatal period, GH does not appear to have a major influence on fetal growth, whereas IGF-I does. Infants with congenital GH deficiency and defects in the GH-receptor gene have only mild retardation of growth at birth,2–4 whereas transgenic mice with a homozygous defect of the IGF-I gene (IGF-I knockout mice) have profound embryonic and postnatal growth retardation.5–7 Although there is no direct evidence that IGF-I has a prominent role in human fetal growth, fetal tissues express IGF-I from . . .

[1]  S. Chua,et al.  Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse , 1996, Nature Genetics.

[2]  T. Clackson,et al.  Mutations of the growth hormone receptor in children with idiopathic short stature. The Growth Hormone Insensitivity Study Group. , 1995, The New England journal of medicine.

[3]  A. Clark,et al.  The molecular pathology of pituitary hormone deficiency and resistance. , 1995, Bailliere's clinical endocrinology and metabolism.

[4]  T J Cole,et al.  Cross sectional stature and weight reference curves for the UK, 1990. , 1995, Archives of disease in childhood.

[5]  L. Giudice,et al.  Insulin-like growth factors and their binding proteins in the term and preterm human fetus and neonate with normal and extremes of intrauterine growth. , 1995, The Journal of clinical endocrinology and metabolism.

[6]  S. Chew,et al.  An alternatively spliced human insulin-like growth factor-I transcript with hepatic tissue expression that diverts away from the mitogenic IBE1 peptide. , 1995, Endocrinology.

[7]  F. Hefti,et al.  Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons , 1995, Neuron.

[8]  J. Guevara-Aguirre,et al.  Growth hormone (GH) insensitivity due to primary GH receptor deficiency. , 1994, Endocrine reviews.

[9]  R. Baxter,et al.  The composition and distribution of insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) in the serum of growth hormone receptor-deficient patients: effects of IGF-I therapy on IGFBP-3. , 1993, The Journal of clinical endocrinology and metabolism.

[10]  L. Powell-Braxton,et al.  IGF-I is required for normal embryonic growth in mice. , 1993, Genes & development.

[11]  M. Preece,et al.  Clinical features and endocrine status in patients with growth hormone insensitivity (Laron syndrome). , 1993, The Journal of clinical endocrinology and metabolism.

[12]  J. Baker,et al.  Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r) , 1993, Cell.

[13]  Elizabeth J. Robertson,et al.  Role of insulin-like growth factors in embryonic and postnatal growth , 1993, Cell.

[14]  A. D'ercole.  Expression of Insulin‐like Growth Factor‐I in Transgenic Mice a , 1993, Annals of the New York Academy of Sciences.

[15]  A. Gunn,et al.  Congenital idiopathic growth hormone deficiency associated with prenatal and early postnatal growth failure. The International Board of the Kabi Pharmacia International Growth Study. , 1992, The Journal of pediatrics.

[16]  M. Binoux,et al.  Serum Insulin-Like Growth Factors and Insulin-Like Growth Factor Binding Proteins in the Human Fetus. Relationships with Growth in Normal Subjects and in Subjects with Intrauterine Growth Retardation , 1991, Pediatric Research.

[17]  R. Baxter,et al.  Circulating levels and molecular distribution of the acid-labile (alpha) subunit of the high molecular weight insulin-like growth factor-binding protein complex. , 1990, The Journal of clinical endocrinology and metabolism.

[18]  Y. Le Bouc,et al.  Molecular forms of serum insulin-like growth factor (IGF)-binding proteins in man: relationships with growth hormone and IGFs and physiological significance. , 1989, The Journal of clinical endocrinology and metabolism.

[19]  G. Novelli,et al.  Laron dwarfism and mutations of the growth hormone-receptor gene. , 1989, The New England journal of medicine.

[20]  M. Preece,et al.  A monoclonal antibody to human insulin-like growth factor-I: characterization, use in radioimmunoassay and effect on the biological activities of the growth factor. , 1989, Journal of molecular endocrinology.

[21]  E. Froesch,et al.  Recombinant human insulin-like growth factor I induces its own specific carrier protein in hypophysectomized and diabetic rats. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[22]  M. Ranke,et al.  A specific radioimmunoassay for insulin-like growth factor II: the interference of IGF binding proteins can be blocked by excess IGF-I. , 1988, Acta endocrinologica.

[23]  V. Han,et al.  Expression of somatomedin/insulin-like growth factor messenger ribonucleic acids in the human fetus: identification, characterization, and tissue distribution. , 1988, The Journal of clinical endocrinology and metabolism.

[24]  A. Lindahl,et al.  Mechanism of the stimulatory effect of growth hormone on longitudinal bone growth. , 1987, Endocrine reviews.

[25]  R. Naeye.  Do placental weights have clinical significance? , 1987, Human pathology.

[26]  M. Binoux,et al.  Analysis of serum insulin-like growth factor binding proteins using western blotting: use of the method for titration of the binding proteins and competitive binding studies. , 1986, Analytical biochemistry.

[27]  A. Ullrich,et al.  Human chromosomal mapping of genes for insulin-like growth factors I and II and epidermal growth factor , 1984, Nature.

[28]  N. Cameron,et al.  The Methods of Auxological Anthropometry , 1978 .