Proteopedia: a status report on the collaborative, 3D web-encyclopedia of proteins and other biomolecules.

Proteopedia is a collaborative, 3D web-encyclopedia of protein, nucleic acid and other biomolecule structures. Created as a means for communicating biomolecule structures to a diverse scientific audience, Proteopedia (http://www.proteopedia.org) presents structural annotation in an intuitive, interactive format and allows members of the scientific community to easily contribute their own annotations. Here, we provide a status report on Proteopedia by describing advances in the web resource since its inception three and a half years ago, focusing on features of potential direct use to the scientific community. We discuss its progress as a collaborative 3D-encyclopedia of structures as well as its use as a complement to scientific publications and PowerPoint presentations. We also describe Proteopedia's use for 3D visualization in structure-related pedagogy.

[1]  Hans Neurath,et al.  The Kinemage: A tool for scientific communication , 1996 .

[2]  Itay Mayrose,et al.  ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures , 2005, Nucleic Acids Res..

[3]  Alexander Grahn,et al.  Leaving the structural ivory tower, assisted by interactive 3D PDF. , 2010, Trends in biochemical sciences.

[4]  M. Gerstein,et al.  The morph server: a standardized system for analyzing and visualizing macromolecular motions in a database framework. , 2000, Nucleic acids research.

[5]  J. Kendrew,et al.  A Three-Dimensional Model of the Myoglobin Molecule Obtained by X-Ray Analysis , 1958, Nature.

[6]  Ruben Abagyan,et al.  SGC - Structural Biology and Human Health: A New Approach to Publishing Structural Biology Results , 2009, PloS one.

[7]  Mark Gerstein,et al.  The Database of Macromolecular Motions: new features added at the decade mark , 2005, Nucleic Acids Res..

[8]  J. Igarashi,et al.  A hydrogen-bonding network formed by the B10–E7–E11 residues of a truncated hemoglobin from Tetrahymena pyriformis is critical for stability of bound oxygen and nitric oxide detoxification , 2011, JBIC Journal of Biological Inorganic Chemistry.

[9]  Karl Oberholser,et al.  Proteopedia entry: Ramachandran plots , 2010, Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology.

[10]  O. Dym,et al.  Crystal structure of the Agrobacterium virulence complex VirE1-VirE2 reveals a flexible protein that can accommodate different partners , 2008, Proceedings of the National Academy of Sciences.

[11]  M. Lewis,et al.  lac repressor: crystallization of intact tetramer and its complexes with inducer and operator DNA. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[12]  Jaime Prilusky,et al.  Proteopedia - a scientific 'wiki' bridging the rift between three-dimensional structure and function of biomacromolecules , 2008, Genome Biology.

[13]  Fei Wang,et al.  Scavenger receptor WC1 contributes to the γδ T cell response to Leptospira. , 2011, Molecular immunology.

[14]  Michael Sheetz,et al.  Molecules in motion , 1994, Nature.

[15]  David Canner Proteopedia entry: HMG‐CoA reductase , 2011, Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology.

[16]  Robert M. Hanson,et al.  A toolkit for publishing enhanced figures , 2008, Journal of applied crystallography.

[17]  T. Hahn International tables for crystallography , 2002 .

[18]  A. Antson,et al.  Structural investigation of transcriptional regulator HlyIIR: Influence of a disordered region on protein fold and dimerization , 2010, Proteins.

[19]  Robert M. Hanson,et al.  Jmol – a paradigm shift in crystallographic visualization , 2010 .

[20]  Arthur G. Palmer,et al.  Interactive graphics return to protein science , 2009 .

[21]  Jaime Prilusky,et al.  The Protein Data Bank at Brookhaven , 2006 .

[22]  Haruki Nakamura,et al.  The worldwide Protein Data Bank (wwPDB): ensuring a single, uniform archive of PDB data , 2006, Nucleic Acids Res..

[23]  R. Kaptein,et al.  Structure and Flexibility Adaptation in Nonspecific and Specific Protein-DNA Complexes , 2004, Science.

[24]  T. G. Cowling,et al.  Molecules in Motion , 1950 .

[25]  Andreas Ziegler,et al.  Grasping molecular structures through publication-integrated 3D models. , 2008, Trends in biochemical sciences.

[26]  Wayne A. Decatur Proteopedia entry: The large ribosomal subunit of Haloarcula marismortui , 2010, Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology.

[27]  Ruben Abagyan,et al.  Disseminating structural genomics data to the public: from a data dump to an animated story. , 2006, Trends in biochemical sciences.

[28]  Ivano Bertini,et al.  Sco proteins are involved in electron transfer processes , 2011, JBIC Journal of Biological Inorganic Chemistry.