Mechanisms of Airway Obstruction in Robin Sequence: Implications for Treatment

Though the problems associated with Robin sequence may be numerous, especially if the primary cause of the sequence is a multiple anomaly syndrome, the most acute problems in affected newborns Is upper airway obstruction. Until recently It has been tacitly assumed that glossoptosis is always the cause of the airway obstruction. More recent evidence has shown that the sources of airway obstruction are multiple and the cause of apnea heterogeneous. The purpose of this paper is to report the mechanisms of upper airway obstruction In 53 Infants with Robin sequence. The use of flexible fiber optic endoscopy to specify treatment is discussed in detail.

[1]  R. Shprintzen.  The implications of the diagnosis of Robin sequence. , 1992, The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association.

[2]  R. Argamaso.  Glossopexy for upper airway obstruction in Robin sequence. , 1992, The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association.

[3]  R. Shprintzen.  PIERRE ROBIN, MICROGNATHIA, AND AIRWAY OBSTRUCTION: THE DEPENDENCY OF TREATMENT ON ACCURATE DIAGNOSIS , 1988, International Anesthesiology Clinics.

[4]  R. Shprintzen,et al.  Endoscopic observations of obstructive sleep apnea in children with anomalous upper airways: predictive and therapeutic value. , 1986, International journal of pediatric otorhinolaryngology.

[5]  A. Pierro,et al.  Glossoptosis-apnea syndrome in infancy. , 1985, Pediatrics.

[6]  R. Dinwiddie,et al.  Nasopharyngeal airways in Pierre Robin syndrome , 1982, The Journal of pediatrics.

[7]  K. Togawa,et al.  Influence of upper airway obstruction by enlarged tonsils and adenoids upon recurrent infection of the lower airway in childhood , 1980, The Laryngoscope.

[8]  M. K. Freeman,et al.  Cor pulmonale and the Pierre Robin anomaly , 1980, Anaesthesia.

[9]  R. Shprintzen,et al.  Deletion of a portion of the long arm of chromosome 6. , 1980, American journal of medical genetics.

[10]  J. Mcfarlane,et al.  Neonatal respiratory distress , 1978, The Journal of Laryngology & Otology.

[11]  F. Cozzi.  GLOSSOPTOSIS AS CAUSE OF APNŒIC SPELLS IN INFANTS WITH CHOANAL ATRESIA , 1977, The Lancet.

[12]  J. Gershanik,et al.  Nasoesophageal Intubation in the Pierre Robin Syndrome , 1976 .

[13]  J. Cogswell,et al.  Cor pulmonale in the Pierre Robin syndrome. , 1974, Archives of disease in childhood.

[14]  E. Fonkalsrud,et al.  Management of by Prolonged: Pierre Robin Syndrome in Infancy Nasoesophageal Intubation , 1972 .

[15]  P. Farnsworth,et al.  Glossoptotic hypoxia and micrognathia--the Pierre Robin syndrome reviewed. Early recognition and prompt surgical treatment is important for survival. , 1971, Clinical pediatrics.

[16]  C. Blanchard,et al.  Pierre robin syndrome pathophysiology of obstructive episodes , 1969, The Laryngoscope.

[17]  W. Dennison.  The Pierre Robin syndrome. , 1965, Pediatrics.

[18]  S. Axtrup.  Treatment of Micrognathia , 1963, Acta paediatrica. Supplementum.

[19]  J. Bosma,et al.  Disability of Oral Function in an Infant Associated with Displacement of the Tongue Therapy by Feeding in Prone Position , 1960, Acta paediatrica. Supplementum.

[20]  R. Routledge.  The pierre-robin syndrome: A surgical emergency in the neonatal period , 1960 .

[21]  S. Pruzansky,et al.  Growth of mandible in infants with micrognathia; clinical implications. , 1954, A.M.A. American journal of diseases of children.

[22]  W. Kiskadden,et al.  REVIEW OF THE TREATMENT OF MICROGNATHIA , 1953, Plastic and reconstructive surgery.

[23]  S. Sjölin.  Hypoplasia of the Mandible as a Cause of Respiratory Difficulties in the Infant , 1950 .

[24]  B. Douglas.  Further report on the treatment of micrognathia with obstruction by a plastic procedure; results based on reports from 21 cities; 1948-1949. , 1950, Plastic and reconstructive surgery.

[25]  B. Douglas.  THE TREATMENT OF MICROGNATHIA ASSOCIATED WITH OBSTRUCTION BY A PLASTIC PROCEDURE , 1946, Plastic and reconstructive surgery.

[26]  P. Robin.  GLOSSOPTOSIS DUE TO ATRESIA AND HYPOTROPHY OF THE MANDIBLE , 1934 .