Expression of p 63 in primary diffuse large B-cell lymphoma of the uterine cervix mimicking low differentiated squamous cell carcinoma

Diffuse large B-cell lymphoma (DLBCL), a common type of non-Hodgkin lymphoma, is usually presenting in lymph nodes or extranodal sites. The most common extranodal site is the gastrointestinal tract. The occurrence in the uterine cervix is exceptional rare. Histologically, this tumor is characterized by a diffuse proliferation of large atypical B-cells. Occasionally the neoplastic cells are display features of signet ring cells. P63 was considered as commonly useful epithelial markers to distinguish carcinoma from lymphoma, but the expression of P63 had also been seen in some lymphoma. Herein, we present a case of DLBCL in a 64-year-old Chinese female. The tumor was predominantly composed of abundant large atypical B-cells with P63-positive and scattered T-cells and histiocytes, focally signet ring-like cells are presented reminiscent of low differentiated squamous cell carcinoma.

[1]  D. Biau,et al.  Primary bone diffuse large B-cell lymphoma: a retrospective evaluation on 76 cases from French institutional and LYSA studies , 2016, Leukemia & lymphoma.

[2]  Zhong-wen Lv,et al.  Primary diffuse large B-cell lymphoma of the dura with skull and scalp involvement: A case report and brief review of the literature , 2016, Oncology letters.

[3]  M. Joks,et al.  Diffuse large B-cell lymphoma of the breast: prognostic factors and treatment outcomes , 2016, OncoTargets and therapy.

[4]  Xiangming Zhu,et al.  Ultrasonographic features of aggressive primary thyroid diffuse B-cell lymphoma: A report of two cases. , 2016, Oncology letters.

[5]  W. Choi,et al.  p63 expression confers significantly better survival outcomes in high-risk diffuse large B-cell lymphoma and demonstrates p53-like and p53-independent tumor suppressor function , 2016, Aging.

[6]  S. Aksoy,et al.  Primary testicular lymphoma: Two case reports and review of the literature. , 2016, Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica.

[7]  E. Villatoro,et al.  Spontaneous rupture of the spleen as a result of primary splenic lymphoma , 2016, Journal of surgical case reports.

[8]  L. Medeiros,et al.  High levels of regulatory T cells in blood are a poor prognostic factor in patients with diffuse large B-cell lymphoma. , 2015, American journal of clinical pathology.

[9]  P. Das,et al.  Primary hepatic lymphoma. , 2015, Tropical gastroenterology : official journal of the Digestive Diseases Foundation.

[10]  K. Yamazaki,et al.  Primary uterine diffuse large B-cell lymphoma involving the urinary bladder with urinary cytology mimicking carcinomas: A case report , 2015, Journal of cytology.

[11]  Shuan-Shuan Guo,et al.  Primary renal diffuse large B-cell lymphoma with central nervous system involvement: a rare case report and literature review. , 2015, International journal of clinical and experimental pathology.

[12]  N. Komatsu,et al.  Diffuse large B-cell lymphoma solely involving bilateral adrenal glands and stomach: report of an extremely rare case with review of the literature. , 2014, International journal of clinical and experimental pathology.

[13]  P. Jayalakshmi,et al.  Waldeyer Ring Lymphoma: A Case Series , 2014, Ear, nose, & throat journal.

[14]  V. White,et al.  Orbital signet-ring cell lymphoma of diffuse, large, B-cell type. , 2013, Canadian journal of ophthalmology. Journal canadien d'ophtalmologie.

[15]  S. Bener,et al.  Prognostic Significance of Bcl-2 and p53 Protein Expressions and Ki67 Proliferative Index in Diffuse Large B-cell Lymphoma , 2013, Turkish journal of haematology : official journal of Turkish Society of Haematology.

[16]  J. F. Magee,et al.  Calretinin Staining Facilitates Differentiation of Olfactory Neuroblastoma From Other Small Round Blue Cell Tumors in the Sinonasal Tract , 2011, The American journal of surgical pathology.

[17]  B. Vojtesek,et al.  The role of P63 in cancer, stem cells and cancer stem cells , 2011, Cellular & Molecular Biology Letters.

[18]  D. de Jong,et al.  Commentary on the WHO classification of tumors of lymphoid tissues (2008): aggressive B-cell lymphomas , 2009, Journal of hematopathology.

[19]  J. Pereira,et al.  p63 Protein expression in high risk diffuse large B-cell lymphoma , 2008, Journal of Clinical Pathology.

[20]  Z. Kojs,et al.  [Primary diffuse large B-cell lymphoma of the uterine cervix - case report]. , 2016, Ginekologia polska.

[21]  T. Terada.  Primary diffuse large B-cell lymphoma of the submandibular gland. , 2012, International journal of clinical and experimental pathology.

[22]  Sang Hyuk Park,et al.  A rare case of diffuse large B cell lymphoma-associated hemophagocytic syndrome initially present in the bone marrow with a favorable clinical course , 2016, Blood research.