Visfatin/PBEF/Nampt: structure, regulation and potential function of a novel adipokine.

Over the last few years, it has become obvious that obesity and insulin resistance are linked by a variety of proteins secreted by adipocytes. Visfatin/PBEF (pre-B-cell colony-enhancing factor) has recently been identified as a novel adipokine with insulin-mimetic effects. Furthermore, an enzymatic function has been reported that reveals visfatin/PBEF as Nampt (nicotinamide phosphoribosyltransferase; EC 2.4.2.12.). Moreover, reports on the structure and hormonal regulation of visfatin/PBEF/Nampt have given further insights into its potential physiological role. The present review summarizes studies on visfatin/PBEF/Nampt as a novel adipokine.

[1]  M. Blüher,et al.  Molecular characteristics of serum visfatin and differential detection by immunoassays. , 2007, The Journal of clinical endocrinology and metabolism.

[2]  N. Kohno,et al.  Circulating visfatin level is correlated with inflammation, but not with insulin resistance , 2007, Clinical endocrinology.

[3]  R. Nazar,et al.  Borrowing from Biology , 2007, Science.

[4]  D. Grattan,et al.  Fasting-induced adipose factor identified as a key adipokine that is up-regulated in white adipose tissue during pregnancy and lactation in the rat. , 2007, The Journal of endocrinology.

[5]  E. Tsai,et al.  Increased plasma visfatin concentrations in women with polycystic ovary syndrome. , 2007, Fertility and sterility.

[6]  M. Matsuda,et al.  Visfatin is released from 3T3-L1 adipocytes via a non-classical pathway. , 2007, Biochemical and biophysical research communications.

[7]  Daniel P Morse,et al.  Direct selection of RNA beacon aptamers. , 2007, Biochemical and biophysical research communications.

[8]  M. Rauh,et al.  Preanalytical influences on the measurement of visfatin by enzyme immuno assay. , 2007, Clinica chimica acta; international journal of clinical chemistry.

[9]  K. Cianflone,et al.  Visfatin expression is hormonally regulated by metabolic and sex hormones in 3T3‐L1 pre‐adipocytes and adipocytes , 2007, Diabetes, obesity & metabolism.

[10]  H. J. Yoo,et al.  Effect of PPAR-δ agonist on the expression of visfatin, adiponectin, and resistin in rat adipose tissue and 3T3-L1 adipocytes , 2007 .

[11]  S. Cregan,et al.  Extension of Human Cell Lifespan by Nicotinamide Phosphoribosyltransferase* , 2007, Journal of Biological Chemistry.

[12]  H. Randeva,et al.  Elevated serum levels of visfatin in gestational diabetes: a comparative study across various degrees of glucose tolerance , 2007, Diabetologia.

[13]  M. Fasshauer,et al.  Differential regulation of visfatin and adiponectin in pregnancies with normal and abnormal placental function , 2007, Clinical endocrinology.

[14]  S. Tonstad,et al.  Increased Expression of Visfatin in Macrophages of Human Unstable Carotid and Coronary Atherosclerosis: Possible Role in Inflammation and Plaque Destabilization , 2007, Circulation.

[15]  J. Carrero,et al.  Circulating levels of visfatin/pre-B-cell colony-enhancing factor 1 in relation to genotype, GFR, body composition, and survival in patients with CKD. , 2007, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[16]  W. Ricart,et al.  Effect of massive weight loss on inflammatory adipocytokines and the innate immune system in morbidly obese women. , 2007, The Journal of clinical endocrinology and metabolism.

[17]  Bounleut Phanavanh,et al.  Human visfatin expression: relationship to insulin sensitivity, intramyocellular lipids, and inflammation. , 2007, The Journal of clinical endocrinology and metabolism.

[18]  H. Tilg,et al.  Visfatin , an Adipocytokine with Proinflammatory and Immunomodulating Properties 1 , 2007 .

[19]  W. Qian.  Plasma visfatin levels in patients with newly diagnosed and untreated type 2 diabetes mellitus and impaired glucose tolerance , 2007 .

[20]  B. Pedersen,et al.  Visfatin mRNA expression in human subcutaneous adipose tissue is regulated by exercise. , 2007, American journal of physiology. Endocrinology and metabolism.

[21]  Joe G. N. Garcia,et al.  Genomic insights into acute inflammatory lung injury. , 2006, American journal of physiology. Lung cellular and molecular physiology.

[22]  H. Randeva,et al.  Increased visfatin messenger ribonucleic acid and protein levels in adipose tissue and adipocytes in women with polycystic ovary syndrome: parallel increase in plasma visfatin. , 2006, The Journal of clinical endocrinology and metabolism.

[23]  G. Schernthaner,et al.  Increase in Visfatin after Weight Loss Induced by Gastroplastic Surgery , 2006, Obesity.

[24]  M. Wolzt,et al.  Exercise training lowers plasma visfatin concentrations in patients with type 1 diabetes. , 2006, The Journal of clinical endocrinology and metabolism.

[25]  M. Wolzt,et al.  Free fatty acids normalize a rosiglitazone-induced visfatin release. , 2006, American journal of physiology. Endocrinology and metabolism.

[26]  M. Matsuda,et al.  Visfatin in adipocytes is upregulated by hypoxia through HIF1alpha-dependent mechanism. , 2006, Biochemical and biophysical research communications.

[27]  K. Cianflone,et al.  Effects of fatty acid regulation on visfatin gene expression in adipocytes. , 2006, Chinese medical journal.

[28]  M. Wolzt,et al.  The Adipokine Visfatin is Markedly Elevated in Obese Children , 2006, Journal of pediatric gastroenterology and nutrition.

[29]  J. Fernández-Real,et al.  Serum Visfatin Increases With Progressive β-Cell Deterioration , 2006, Diabetes.

[30]  S. Eom,et al.  Crystal structure of visfatin/pre-B cell colony-enhancing factor 1/nicotinamide phosphoribosyltransferase, free and in complex with the anti-cancer agent FK-866. , 2006, Journal of molecular biology.

[31]  T. Forst,et al.  Comment on: Haider DG, Schaller G, Kapiotis S, Maier C, Luger A, Wolzt M (2006) The release of the adipocytokine visfatin is regulated by glucose and insulin. Diabetologia 49:1909–1914 , 2006, Diabetologia.

[32]  R. Vettor,et al.  Reduced plasma visfatin/pre-B cell colony-enhancing factor in obesity is not related to insulin resistance in humans. , 2006, The Journal of clinical endocrinology and metabolism.

[33]  M. Yoo,et al.  Hypoxic induction of human visfatin gene is directly mediated by hypoxia‐inducible factor‐1 , 2006, FEBS letters.

[34]  C. Fielding,et al.  Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 trans-signaling: implications in the pathogenesis of rheumatoid arthritis. , 2006, Arthritis and rheumatism.

[35]  E. Tsai,et al.  Decreased Plsma Visfatin Concentrations in Women With Gestational Diabetes Mellitus , 2006, The Journal of the Society for Gynecologic Investigation: JSGI.

[36]  C. Wolberger,et al.  Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme , 2006, Nature Structural &Molecular Biology.

[37]  G. Schernthaner,et al.  Increased visfatin concentrations in women with gestational diabetes mellitus. , 2006, Clinical science.

[38]  M. Wolzt,et al.  Increased plasma visfatin concentrations in morbidly obese subjects are reduced after gastric banding. , 2006, The Journal of clinical endocrinology and metabolism.

[39]  M. Laakso,et al.  Visfatin is an adipokine, but it is not regulated by thiazolidinediones. , 2006, The Journal of clinical endocrinology and metabolism.

[40]  R. Busse,et al.  Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and visfatin , 2006, Diabetologia.

[41]  J. Gómez-Reino,et al.  Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis , 2006, Annals of the rheumatic diseases.

[42]  Shyi-Jang Shin,et al.  Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus. , 2006, The Journal of clinical endocrinology and metabolism.

[43]  Yohei Hayashi,et al.  Rhythmic messenger ribonucleic acid expression of clock genes and adipocytokines in mouse visceral adipose tissue. , 2005, Endocrinology.

[44]  S. Ye,et al.  Pre-B-cell-colony-enhancing factor is critically involved in thrombin-induced lung endothelial cell barrier dysregulation. , 2005, Microvascular research.

[45]  K. Choi,et al.  Effect of PPAR-α and -γ agonist on the expression of visfatin, adiponectin, and TNF-α in visceral fat of OLETF rats☆ , 2005 .

[46]  M. Fasshauer,et al.  Plasma visfatin concentrations and fat depot-specific mRNA expression in humans. , 2005, Diabetes.

[47]  R. Paschke,et al.  Interleukin-6 is a negative regulator of visfatin gene expression in 3T3-L1 adipocytes. , 2005, American journal of physiology. Endocrinology and metabolism.

[48]  M. Matsuda,et al.  Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. , 2005, Science.

[49]  Reinhard Guthke,et al.  Gene expression profiling of peripheral blood mononuclear leukocytes from psoriasis patients identifies new immune regulatory molecules. , 2005, European journal of dermatology : EJD.

[50]  N. Klöting,et al.  Visfatin: gene expression in isolated adipocytes and sequence analysis in obese WOKW rats compared with lean control rats. , 2005, Biochemical and biophysical research communications.

[51]  J. Pickering,et al.  Pre–B-Cell Colony–Enhancing Factor Regulates NAD+-Dependent Protein Deacetylase Activity and Promotes Vascular Smooth Muscle Cell Maturation , 2005, Circulation research.

[52]  R. Paschke,et al.  Hormonal regulation of the novel adipocytokine visfatin in 3T3-L1 adipocytes. , 2005, The Journal of endocrinology.

[53]  S. Imai,et al.  The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells* , 2004, Journal of Biological Chemistry.

[54]  J. Marshall,et al.  Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. , 2004, The Journal of clinical investigation.

[55]  J. Capeau,et al.  Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone. , 2003, Biochemical and biophysical research communications.

[56]  H. Fujisawa,et al.  Growth phase‐dependent changes in the subcellular localization of pre‐B‐cell colony‐enhancing factor 1 , 2003, FEBS letters.

[57]  D. Gigot,et al.  Pre‐B‐cell colony‐enhancing factor, whose expression is up‐regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis , 2002, European journal of immunology.

[58]  S. Ognjanovic,et al.  Genomic organization of the gene coding for human pre-B-cell colony enhancing factor and expression in human fetal membranes. , 2001, Journal of molecular endocrinology.

[59]  J. Després,et al.  Obesity and Insulin Resistance , 1999 .

[60]  B. Spiegelman,et al.  Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling. , 1997, The Journal of clinical investigation.

[61]  S. Snyder,et al.  Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. , 1994, Science.

[62]  I McNiece,et al.  Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor , 1994, Molecular and cellular biology.