A muscle specific protein “myoferlin” modulates IL-6/STAT3 signaling by chaperoning activated STAT3 to nucleus

[1]  T. Teknos,et al.  High expression of myoferlin is associated with poor outcome in oropharyngeal squamous cell carcinoma patients and is inversely associated with HPV-status , 2016, Oncotarget.

[2]  Nai-jun Fan,et al.  Identification of Differentially Expressed Proteins of Normal and Cancerous Human Colorectal Tissues by Liquid Chromatograph-Mass Spectrometer Based on iTRAQ Approach , 2015, Cancer investigation.

[3]  Xuebin Wang,et al.  Decreased expression and prognostic role of EHD2 in human breast carcinoma: correlation with E-cadherin , 2015, Journal of Molecular Histology.

[4]  A. Yadav,et al.  Suberoylanilide hydroxamic acid (SAHA) reverses chemoresistance in head and neck cancer cells by targeting cancer stem cells via the downregulation of nanog , 2015, Genes & cancer.

[5]  Xiaojing Yang,et al.  Role of EHD2 in migration and invasion of human breast cancer cells , 2015, Tumor Biology.

[6]  P. Delvenne,et al.  Myoferlin is a key regulator of EGFR activity in breast cancer. , 2013, Cancer research.

[7]  P. Hojman,et al.  The role of intratumoral and systemic IL-6 in breast cancer , 2013, Breast Cancer Research and Treatment.

[8]  Song He,et al.  Effects of EHD2 interference on migration of esophageal squamous cell carcinoma , 2013, Medical Oncology.

[9]  S. Ghadiali,et al.  Myoferlin Depletion in Breast Cancer Cells Promotes Mesenchymal to Epithelial Shape Change and Stalls Invasion , 2012, PloS one.

[10]  Avner Friedman,et al.  Mechanistic modeling of the effects of myoferlin on tumor cell invasion , 2011, Proceedings of the National Academy of Sciences.

[11]  J. Datta,et al.  IL-6 Promotes Head and Neck Tumor Metastasis by Inducing Epithelial–Mesenchymal Transition via the JAK-STAT3-SNAIL Signaling Pathway , 2011, Molecular Cancer Research.

[12]  P. Delvenne,et al.  Identification of novel accessible proteins bearing diagnostic and therapeutic potential in human pancreatic ductal adenocarcinoma. , 2011, Journal of proteome research.

[13]  Soraya Utokaparch,et al.  Myoferlin gene silencing decreases Tie-2 expression in vitro and angiogenesis in vivo. , 2011, Vascular pharmacology.

[14]  N. Fusenig,et al.  IL‐6 promotes malignant growth of skin SCCs by regulating a network of autocrine and paracrine cytokines , 2011, International journal of cancer.

[15]  Gabriel Wong,et al.  Stem Cell Marker (Nanog) and Stat-3 Signaling Promote MicroRNA-21 Expression and Chemoresistance in Hyaluronan/CD44-activated Head and Neck Squamous Cell Carcinoma Cells , 2011, Oncogene.

[16]  Shizuo Akira,et al.  Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. , 2011, Cancer cell.

[17]  U. Cortes,et al.  STAT3 is essential for the maintenance of neurosphere‐initiating tumor cells in patients with glioblastomas: A potential for targeted therapy? , 2011, International journal of cancer.

[18]  M. Rout,et al.  The nuclear pore complex and nuclear transport. , 2010, Cold Spring Harbor perspectives in biology.

[19]  E. Svensson,et al.  Myoferlin regulation by NFAT in muscle injury, regeneration and repair , 2010, Journal of Cell Science.

[20]  T. Carey,et al.  Genotyping of 73 UM‐SCC head and neck squamous cell carcinoma cell lines , 2009, Head & neck.

[21]  W. Sessa,et al.  Myoferlin is critical for endocytosis in endothelial cells. , 2009, American journal of physiology. Cell physiology.

[22]  G. Wolf,et al.  Interleukin‐6 predicts recurrence and survival among head and neck cancer patients , 2008, Cancer.

[23]  Gregory Q. Wallace,et al.  The Endocytic Recycling Protein EHD2 Interacts with Myoferlin to Regulate Myoblast Fusion* , 2008, Journal of Biological Chemistry.

[24]  Yu Ning,et al.  Endothelial cells expressing Bcl-2 promotes tumor metastasis by enhancing tumor angiogenesis, blood vessel leakiness and tumor invasion , 2008, Laboratory Investigation.

[25]  A. Ruddell,et al.  Lymph node mapping in the mouse. , 2008, Journal of immunological methods.

[26]  Zhongxin Lu,et al.  Phosphorylation and nuclear translocation of STAT3 regulated by the Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma. , 2008, International journal of molecular medicine.

[27]  C. Fernández-Hernando,et al.  Myoferlin Regulates Vascular Endothelial Growth Factor Receptor-2 Stability and Function* , 2007, Journal of Biological Chemistry.

[28]  J. L. Jimenez,et al.  In silico functional and structural characterisation of ferlin proteins by mapping disease-causing mutations and evolutionary information onto three-dimensional models of their C2 domains , 2007, Journal of the Neurological Sciences.

[29]  P. Avan,et al.  Otoferlin, Defective in a Human Deafness Form, Is Essential for Exocytosis at the Auditory Ribbon Synapse , 2006, Cell.

[30]  T. Kishimoto.  Interleukin-6: discovery of a pleiotropic cytokine , 2006, Arthritis research & therapy.

[31]  D. Davis,et al.  Normal myoblast fusion requires myoferlin , 2005, Development.

[32]  Karl Hörmann,et al.  Serum levels of interleukin-6 in patients with primary head and neck squamous cell carcinoma. , 2005, Anticancer research.

[33]  Kevin M. McBride,et al.  STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[34]  Claudia Fischbach,et al.  Combination treatment significantly enhances the efficacy of antitumor therapy by preferentially targeting angiogenesis , 2005, Laboratory Investigation.

[35]  Martín C Abba,et al.  Gene expression signature of estrogen receptor α status in breast cancer , 2005, BMC Genomics.

[36]  H. Auer,et al.  Tissue-Wide Expression Profiling Using cDNA Subtraction and Microarrays to Identify Tumor-Specific Genes , 2004, Cancer Research.

[37]  W. Foulkes,et al.  E6/E7 proteins of HPV type 16 and ErbB-2 cooperate to induce neoplastic transformation of primary normal oral epithelial cells , 2004, Oncogene.

[38]  K. Sayama,et al.  Nuclear Translocation of Phosphorylated STAT3 Is Essential for Vascular Endothelial Growth Factor-induced Human Dermal Microvascular Endothelial Cell Migration and Tube Formation* , 2003, Journal of Biological Chemistry.

[39]  M. Pacyna‐Gengelbach,et al.  Gene expression profiles in human non-small and small-cell lung cancers. , 2003, European journal of cancer.

[40]  Pierre Legrain,et al.  Comprehensive Proteomic Analysis of Breast Cancer Cell Membranes Reveals Unique Proteins with Potential Roles in Clinical Cancer* 210 , 2003, The Journal of Biological Chemistry.

[41]  T. Smithgall,et al.  Activation of STAT3 by the Src Family Kinase Hck Requires a Functional SH3 Domain* , 2002, The Journal of Biological Chemistry.

[42]  P. Real,et al.  Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells , 2002, Oncogene.

[43]  D. Davis,et al.  Calcium-sensitive Phospholipid Binding Properties of Normal and Mutant Ferlin C2 Domains* , 2002, The Journal of Biological Chemistry.

[44]  Yudong D. He,et al.  Gene expression profiling predicts clinical outcome of breast cancer , 2002, Nature.

[45]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[46]  Y. Horiguchi,et al.  Serum interleukin 6 as a prognostic factor in patients with prostate cancer. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

[47]  D. DeFranco.  Role of molecular chaperones in subnuclear trafficking of glucocorticoid receptors. , 2000, Kidney international.

[48]  D. Davis,et al.  Myoferlin, a candidate gene and potential modifier of muscular dystrophy. , 2000, Human molecular genetics.

[49]  Pieter J. de Jong,et al.  Dysferlin, a novel skeletal muscle gene, is mutated in Miyoshi myopathy and limb girdle muscular dystrophy , 1998, Nature Genetics.

[50]  P. Heinrich,et al.  Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. , 1998, The Biochemical journal.

[51]  J. Darnell,et al.  Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. , 1994, Science.

[52]  K. Yasukawa,et al.  IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. , 1993, Science.

[53]  T. Hirano,et al.  Molecular cloning and expression of an IL-6 signal transducer, gp130 , 1990, Cell.

[54]  T. Südhof,et al.  Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C , 1990, Nature.

[55]  T. Hirano,et al.  Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130 , 1989, Cell.

[56]  T. Taniguchi,et al.  Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor. , 1988, Science.

[57]  P. Lamb,et al.  Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor. , 1994, Blood.