ProteinImmune Responses to Prion Protein Conformation Significantly

H. Hawke, Graham S. Jackson and John CollingeLinda Summers, Mourad Tayebi, Anthony R. Clarke, Simon Azadeh Khalili-Shirazi, Sonia Quaratino, Marco Londei,http://www.jimmunol.org/content/174/6/3256J Immunol€2005; 174:3256-3263; ;Referenceshttp://www.jimmunol.org/content/174/6/3256.full#ref-list-1This article cites 49 articles, 20 of which you can access for free at: Subscriptionshttp://jimmunol.org/subscriptionsInformation about subscribing to The Journal of Immunology is online at: Permissionshttp://www.aai.org/ji/copyright.htmlSubmit copyright permission requests at: Email Alertshttp://jimmunol.org/cgi/alerts/etocReceive free email-alerts when new articles cite this article. Sign up at:

[1]  R. Steinman.  Some interfaces of dendritic cell biology , 2003, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[2]  A. Aguzzi,et al.  A crucial role for B cells in neuroinvasive scrapie , 1997, Nature.

[3]  J. Collinge,et al.  Multiple folding pathways for heterologously expressed human prion protein. , 1999, Biochimica et biophysica acta.

[4]  Stanley B. Prusiner,et al.  Scrapie prion protein contains a phosphatidylinositol glycolipid , 1987, Cell.

[5]  E. Shevach,et al.  Role of phosphatidylinositol-anchored proteins in T cell activation. , 1990, Journal of immunology.

[6]  M. Shlomchik,et al.  Neuroinvasion by a Creutzfeldt–Jakob disease agent in the absence of B cells and follicular dendritic cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[7]  A. Kelso.  Th1 and Th2 subsets: paradigms lost? , 1995, Immunology today.

[8]  T. Mosmann,et al.  Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones , 1989, The Journal of experimental medicine.

[9]  R. Coffman,et al.  Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. , 1986, Journal of immunology.

[10]  D. Harris,et al.  A prion protein cycles between the cell surface and an endocytic compartment in cultured neuroblastoma cells. , 1993, The Journal of biological chemistry.

[11]  L. McShane,et al.  Further studies of blood infectivity in an experimental model of transmissible spongiform encephalopathy, with an explanation of why blood components do not transmit Creutzfeldt‐Jakob disease in humans , 1999, Transfusion.

[12]  S. Prusiner,et al.  Molecular biology of prion diseases , 1991, Science.

[13]  D. Porter,et al.  Failure to demonstrate a humoral immune response to scrapie infection in mice. , 1973, Journal of immunology.

[14]  K. Kristensson,et al.  Processing and Degradation of Exogenous Prion Protein by CD11c+ Myeloid Dendritic Cells In Vitro , 2002, Journal of Virology.

[15]  E. Wolf,et al.  Polyclonal Anti-PrP Auto-antibodies Induced with Dimeric PrP Interfere Efficiently with PrPSc Propagation in Prion-infected Cells* , 2003, The Journal of Biological Chemistry.

[16]  S. Prusiner.  Novel proteinaceous infectious particles cause scrapie. , 1982, Science.

[17]  D. Kingsbury,et al.  Evidence for Normal Cell-Mediated Immunity in Scrapie-Infected Mice , 1981, Infection and immunity.

[18]  A. Aguzzi,et al.  Mice devoid of PrP are resistant to scrapie , 1993, Cell.

[19]  N. Mabbott,et al.  T‐lymphocyte activation and the cellular form of the prion protein , 1997, Immunology.

[20]  J Collinge,et al.  Investigation of variant Creutzfeldt-Jakob disease and other human prion diseases with tonsil biopsy samples , 1999, The Lancet.

[21]  L. Hood,et al.  Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing. , 1993, Biochemistry.

[22]  C. V. Mering,et al.  Prion Protein Devoid of the Octapeptide Repeat Region Restores Susceptibility to Scrapie in PrP Knockout Mice , 2000, Neuron.

[23]  F. Mackay,et al.  Temporary inactivation of follicular dendritic cells delays neuroinvasion of scrapie , 2000, Nature Medicine.

[24]  J Collinge,et al.  Reversible conversion of monomeric human prion protein between native and fibrilogenic conformations. , 1999, Science.

[25]  Andrew F. Hill,et al.  Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD , 1996, Nature.

[26]  H. Fraser,et al.  Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells , 1999, Nature Medicine.

[27]  A. Abbas,et al.  Cytokine transcriptional events during helper T cell subset differentiation , 1996, The Journal of experimental medicine.

[28]  A. Pain,et al.  The normal cellular prion protein is strongly expressed by myeloid dendritic cells. , 2001, Blood.

[29]  A. Aguzzi,et al.  Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[30]  S. DeArmond,et al.  T Cells Infiltrate the Brain in Murine and Human Transmissible Spongiform Encephalopathies , 2003, Journal of Virology.

[31]  W. Paul,et al.  Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. , 1987, Science.

[32]  R. Coffman,et al.  TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. , 1989, Annual review of immunology.

[33]  A. Aguzzi,et al.  PrP‐dependent association of prions with splenic but not circulating lymphocytes of scrapie‐infected mice , 1999, The EMBO journal.

[34]  A. Aguzzi,et al.  Impaired prion replication in spleens of mice lacking functional follicular dendritic cells. , 2000, Science.

[35]  Patrick Couvreur,et al.  Role of spleen macrophages in the clearance of scrapie agent early in pathogenesis , 2000, The Journal of pathology.

[36]  J. Collinge,et al.  Structural mobility of the human prion protein probed by backbone hydrogen exchange , 1999, Nature Structural Biology.

[37]  M. Enari,et al.  Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[38]  N. Mabbott,et al.  Migrating intestinal dendritic cells transport PrP(Sc) from the gut. , 2002, The Journal of general virology.

[39]  Neil R. Cashman,et al.  Cellular isoform of the scrapie agent protein participates in lymphocyte activation , 1990, Cell.

[40]  Andrew F. Hill,et al.  The same prion strain causes vCJD and BSE , 1997, Nature.

[41]  M. Sy,et al.  The expression and potential function of cellular prion protein in human lymphocytes. , 2001, Cellular immunology.

[42]  S. Laboissiere,et al.  A prion protein epitope selective for the pathologically misfolded conformation , 2003, Nature Medicine.

[43]  A. Aguzzi,et al.  PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain , 1997, Nature.

[44]  R. L. Chandler.  Encephalopathy in mice produced by inoculation with scrapie brain material. , 1961, Lancet.

[45]  S. Cousens,et al.  Transmissions to mice indicate that ‘new variant’ CJD is caused by the BSE agent , 1997, Nature.

[46]  V. Manganelli,et al.  Prion protein is a component of the multimolecular signaling complex involved in T cell activation , 2004, FEBS letters.

[47]  E. Sigurdsson,et al.  Immunization delays the onset of prion disease in mice. , 2002, The American journal of pathology.

[48]  J. Collinge,et al.  Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay , 2001, The Lancet.