The current status of 3D bioprinting for neural tissue models

Neurological disease is one of the devastating diseases worldwide. Limited regeneration capability of central nervous system has greatly hindered the functional recovery of neural tissues. Bioprinting, offers a promising method to deposit cells, materials and instructive biomolecules in a precise arrangement simultaneously, which is possible to achieve the construction of multicellular functional neural tissues. In this review, we have 1) identified the essential design parameters of neural tissue constructs based on native tissue contexts 2) reviewed the updated studies of bioprinting for neural tissue applications 3) discussed the challenges and prospects of bioprinting for neural tissue development.

[1]  Gabor Forgacs,et al.  Biofabrication and testing of a fully cellular nerve graft , 2013, Biofabrication.

[2]  O. Hermanson,et al.  Inkjet printing of macromolecules on hydrogels to steer neural stem cell differentiation. , 2007, Biomaterials.

[3]  Michael C. McAlpine,et al.  3D Printed Anatomical Nerve Regeneration Pathways , 2015, Advanced functional materials.

[4]  Patrick J. Smith,et al.  Inkjet printing Schwann cells and neuronal analogue NG108-15 cells , 2016, Biofabrication.

[5]  Diane Hoffman-Kim,et al.  Three-Dimensional Neural Spheroid Culture: An In Vitro Model for Cortical Studies. , 2015, Tissue engineering. Part C, Methods.

[6]  David L Kaplan,et al.  Bioengineered functional brain-like cortical tissue , 2014, Proceedings of the National Academy of Sciences.

[7]  S. Hsu,et al.  3D bioprinting of neural stem cell-laden thermoresponsive biodegradable polyurethane hydrogel and potential in central nervous system repair. , 2015, Biomaterials.

[8]  Shoji Takeuchi,et al.  Millimeter‐Sized Neural Building Blocks for 3D Heterogeneous Neural Network Assembly , 2013, Advanced healthcare materials.

[9]  Wonhye Lee,et al.  Bio-printing of collagen and VEGF-releasing fibrin gel scaffolds for neural stem cell culture , 2010, Experimental Neurology.

[10]  D. Kaplan,et al.  3D in vitro modeling of the central nervous system , 2015, Progress in Neurobiology.

[11]  Katsuhiko Ariga,et al.  A graphene-polyurethane composite hydrogel as a potential bioink for 3D bioprinting and differentiation of neural stem cells. , 2017, Journal of materials chemistry. B.

[12]  Chee Kai Chua,et al.  3D neural tissue models: From spheroids to bioprinting. , 2018, Biomaterials.

[13]  Daniel R Weinberger,et al.  Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons. , 2016, Cell stem cell.

[14]  Young Hye Kim,et al.  Alzheimer's in 3D culture: Challenges and perspectives , 2015, BioEssays : news and reviews in molecular, cellular and developmental biology.

[15]  Xuan Zhou,et al.  Three-Dimensional-Bioprinted Dopamine-Based Matrix for Promoting Neural Regeneration. , 2018, ACS applied materials & interfaces.

[16]  X. Wen,et al.  Engineering neural stem cell fates with hydrogel design for central nervous system regeneration , 2012 .

[17]  Gordon G Wallace,et al.  3D Bioprinting Human Induced Pluripotent Stem Cell Constructs for In Situ Cell Proliferation and Successive Multilineage Differentiation , 2017, Advanced healthcare materials.

[18]  Tao Xu,et al.  Viability and electrophysiology of neural cell structures generated by the inkjet printing method. , 2006, Biomaterials.

[19]  Elise M. Stewart,et al.  3D printing of layered brain-like structures using peptide modified gellan gum substrates. , 2015, Biomaterials.

[20]  Gordon G Wallace,et al.  Functional 3D Neural Mini‐Tissues from Printed Gel‐Based Bioink and Human Neural Stem Cells , 2016, Advanced healthcare materials.

[21]  Wei Zhu,et al.  Gelatin methacrylamide hydrogel with graphene nanoplatelets for neural cell-laden 3D bioprinting , 2016, 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[22]  Anthony Atala,et al.  3D bioprinting of tissues and organs , 2014, Nature Biotechnology.