Loss of p63 leads to increased cell migration and up-regulation of genes involved in invasion and metastasis.
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Christopher E Barbieri | J. Pietenpol | C. Barbieri | Luojia Tang | Luo Jia Tang | Jennifer A Pietenpol | Kimberly A Brown | K. Brown
[1] M. Nagayama,et al. Downregulation of Wnt4 and upregulation of Wnt5a expression by epithelialmesenchymal transition in human squamous carcinoma cells , 2003, Cancer science.
[2] H. Vogel,et al. p63 is a p53 homologue required for limb and epidermal morphogenesis , 1999, Nature.
[3] P. Hall,et al. Characterization of the expression pattern of p63 alpha and delta Np63 alpha in benign and malignant oral epithelial lesions. , 2000, International journal of cancer.
[4] Philip Lijnzaad,et al. An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas , 2005, Nature Genetics.
[5] O. Ishikawa,et al. Hyaluronan synthase 3 regulates hyaluronan synthesis in cultured human keratinocytes. , 2002, The Journal of investigative dermatology.
[6] J. Capdevila,et al. Epoxyeicosatrienoic Acids Activate Transglutaminases in Situ and Induce Cornification of Epidermal Keratinocytes* , 2003, Journal of Biological Chemistry.
[7] C. Cordon-Cardo,et al. p63 expression profiles in human normal and tumor tissues. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.
[8] M. Augustin,et al. Cloning and chromosomal mapping of the human p53-related KET gene to Chromosome 3q27 and its murine homolog Ket to mouse Chromosome 16 , 1998, Mammalian Genome.
[9] C. Cordon-Cardo,et al. Loss of p63 expression is associated with tumor progression in bladder cancer. , 2002, The American journal of pathology.
[10] P. Altevogt,et al. L1, a novel target of β-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers , 2005, The Journal of cell biology.
[11] R. Hazan,et al. Cadherin Switch in Tumor Progression , 2004, Annals of the New York Academy of Sciences.
[12] Guojun Wu,et al. DeltaNp63alpha up-regulates the Hsp70 gene in human cancer. , 2005, Cancer research.
[13] R. Dellavalle,et al. CUSP/p63 expression in rat and human tissues. , 2001, Journal of dermatological science.
[14] L. Ellisen,et al. p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis. , 2006, Cancer cell.
[15] J. Pietenpol,et al. p53 Regulation of G2 Checkpoint Is Retinoblastoma Protein Dependent , 2000, Molecular and Cellular Biology.
[16] S. Chi,et al. Frequent alteration of p63 expression in human primary bladder carcinomas. , 2000, Cancer research.
[17] D. Ponzin,et al. p63 identifies keratinocyte stem cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[18] B. Trink,et al. p53 associates with and targets Delta Np63 into a protein degradation pathway. , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[19] A. Yang,et al. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. , 1998, Molecular cell.
[20] J. Jen,et al. Frequent gain of the p40/p51/p63 gene locus in primary head and neck squamous cell carcinoma , 2000, International journal of cancer.
[21] L. D. White,et al. Reactivation of developmentally expressed p63 isoforms predisposes to tumor development and progression. , 2006, Cancer research.
[22] Y. Allory,et al. The L1 cell adhesion molecule is induced in renal cancer cells and correlates with metastasis in clear cell carcinomas. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.
[23] C. Arteaga,et al. Autocrine Transforming Growth Factor-β Signaling Mediates Smad-independent Motility in Human Cancer Cells* , 2003, The Journal of Biological Chemistry.
[24] Ming-Rong Wang,et al. Elevated expression of p63 protein in human esophageal squamous cell carcinomas , 2002, International journal of cancer.
[25] A. Yang,et al. Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family. , 2005, Cancer cell.
[26] S. Nomoto,et al. DeltaNp63 induces beta-catenin nuclear accumulation and signaling. , 2002, Cancer cell.
[27] J. Pietenpol,et al. Delta Np63 alpha expression is regulated by the phosphoinositide 3-kinase pathway. , 2003, The Journal of biological chemistry.
[28] K. Kihara,et al. Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of the bladder. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.
[29] J. Jen,et al. AIS is an oncogene amplified in squamous cell carcinoma. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[30] Christopher P. Crum,et al. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development , 1999, Nature.
[31] D. Billheimer,et al. IGFBP-3 is a direct target of transcriptional regulation by DeltaNp63alpha in squamous epithelium. , 2005, Cancer research.
[32] J. Pietenpol,et al. The ΔNp63α Phosphoprotein Binds the p21 and 14-3-3σ Promoters In Vivo and Has Transcriptional Repressor Activity That Is Reduced by Hay-Wells Syndrome-Derived Mutations , 2003, Molecular and Cellular Biology.
[33] Guojun Wu,et al. ΔNp63α Up-Regulates the Hsp70 Gene in Human Cancer , 2005, Cancer Research.
[34] M. Hild,et al. Zebrafish DeltaNp63 is a direct target of Bmp signaling and encodes a transcriptional repressor blocking neural specification in the ventral ectoderm. , 2002, Developmental cell.
[35] Ryan M. Anderson,et al. Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. , 2004, Cancer cell.
[36] C. Bamberger,et al. Identification and tissue distribution of novel KET/p63 splice variants , 2001, FEBS letters.
[37] T. Tokino,et al. deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes. , 2003, Oncogene.
[38] H. Brunner,et al. The p63 gene in EEC and other syndromes , 2002, Journal of medical genetics.
[39] U. Cavallaro. N-cadherin as an invasion promoter: a novel target for antitumor therapy? , 2004, Current opinion in investigational drugs.
[40] Chikashi Ishioka,et al. Cloning and functional analysis of human p51, which structurally and functionally resembles p53 , 1998, Nature Medicine.
[41] A. Mills,et al. p63 is the molecular switch for initiation of an epithelial stratification program. , 2004, Genes & development.
[42] P. Hainaut,et al. TP53 mutations, amplification of P63 and expression of cell cycle proteins in squamous cell carcinoma of the oesophagus from a low incidence area in Western Europe , 2001, British Journal of Cancer.
[43] K. Tsai,et al. p63 and p73 are required for p53-dependent apoptosis in response to DNA damage , 2002, Nature.
[44] R. Bernards,et al. A System for Stable Expression of Short Interfering RNAs in Mammalian Cells , 2002, Science.
[45] Yu Shyr,et al. Significance of p63 amplification and overexpression in lung cancer development and prognosis. , 2003, Cancer research.
[46] T. Tokino,et al. ΔNp63α functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes , 2003, Oncogene.
[47] P. Steinert,et al. Bricks and mortar of the epidermal barrier , 1999, Experimental & Molecular Medicine.
[48] X. Chen,et al. The common and distinct target genes of the p53 family transcription factors , 2004, Cellular and Molecular Life Sciences CMLS.
[49] D. Kimelman,et al. A dominant-negative form of p63 is required for epidermal proliferation in zebrafish. , 2002, Developmental cell.
[50] D. Billheimer,et al. IGFBP-3 Is a Direct Target of Transcriptional Regulation by ΔNp63α in Squamous Epithelium , 2005 .
[51] J. Hornung,et al. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line , 1988, The Journal of cell biology.
[52] M. Schachner,et al. Overexpression of the cell adhesion molecule L1 is associated with metastasis in cutaneous malignant melanoma. , 2002, European journal of cancer.
[53] S. Nomoto,et al. ΔNp63 induces β-catenin nuclear accumulation and signaling , 2002 .
[54] S. Lowe,et al. p63 deficiency activates a program of cellular senescence and leads to accelerated aging. , 2005, Genes & development.
[55] B. Trink,et al. p53 associates with and targets ΔNp63 into a protein degradation pathway , 2001 .
[56] P. Hall,et al. Characterization of the expression pattern of p63α and δnp63α in benign and malignant oral epithelial lesions , 2000 .
[57] A. Yang,et al. p63 and p73: p53 mimics, menaces and more , 2000, Nature Reviews Molecular Cell Biology.
[58] J. Pietenpol,et al. ΔNp63α Expression Is Regulated by the Phosphoinositide 3-Kinase Pathway* , 2003, Journal of Biological Chemistry.