Tumour-stroma interactions in pancreatic ductal adenocarcinoma: rationale and current evidence for new therapeutic strategies.
暂无分享,去创建一个
M. Ychou | M. Reni | D. Richel | M. Ducreux | V. Heinemann | T. Macarulla
[1] F Levi,et al. European cancer mortality predictions for the year 2014. , 2014, Annals of oncology : official journal of the European Society for Medical Oncology.
[2] I. Reis,et al. A Phase II Trial of nab-Paclitaxel as Second-line Therapy in Patients With Advanced Pancreatic Cancer , 2013, American journal of clinical oncology.
[3] M. Hidalgo,et al. Randomized phase III study of weekly nab-paclitaxel plus gemcitabine versus gemcitabine alone in patients with metastatic adenocarcinoma of the pancreas (MPACT). , 2013 .
[4] V. Heinemann,et al. Systemic treatment of advanced pancreatic cancer. , 2012, Cancer treatment reviews.
[5] Edward J. Kim,et al. Abstract A40: Cancer stem cells (CSC) and inhibition of hedgehog (Hh) pathway signaling in advanced pancreatic cancer: GDC-0449 in combination with gemcitabine (Gem). , 2012 .
[6] M. Di Marco,et al. Hedgehog signaling: from the cuirass to the heart of pancreatic cancer. , 2012, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].
[7] M. Hidalgo,et al. Antitumor activity of nab-paclitaxel and gemcitabine in resectable pancreatic cancer. , 2012 .
[8] M. Borad,et al. Targeting hyaluronan (HA) in tumor stroma: A phase I study to evaluate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of pegylated hyaluronidase (PEGPH20) in patients with solid tumors. , 2012 .
[9] F Levi,et al. European cancer mortality predictions for the year 2012. , 2012, Annals of oncology : official journal of the European Society for Medical Oncology.
[10] S. Temple,et al. Molecular Characterisation of Transport Mechanisms at the Developing Mouse Blood–CSF Interface: A Transcriptome Approach , 2012, PloS one.
[11] Carlos Cuevas,et al. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. , 2012, Cancer cell.
[12] Ahmedin Jemal,et al. Cancers with increasing incidence trends in the United States: 1999 through 2008 , 2012, CA: a cancer journal for clinicians.
[13] D. Tuveson,et al. nab-Paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer. , 2012, Cancer discovery.
[14] H. Friess,et al. The impact of the activated stroma on pancreatic ductal adenocarcinoma biology and therapy resistance. , 2012, Current molecular medicine.
[15] C. Fuchs,et al. A phase Ib trial of IPI-926, a hedgehog pathway inhibitor, plus gemcitabine in patients with metastatic pancreatic cancer. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[16] K. Behrns. FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer , 2012 .
[17] A. Tsao. Weekly nab-Paclitaxel in Combination With Carboplatin Versus Solvent-Based Paclitaxel Plus Carboplatin as First-Line Therapy in Patients With Advanced Non–Small-Cell Lung Cancer: Final Results of a Phase III Trial , 2012 .
[18] A. Jemal,et al. Cancer statistics, 2012 , 2012, CA: a cancer journal for clinicians.
[19] S. Kakolyris,et al. Docetaxel plus gemcitabine in combination with capecitabine as treatment for inoperable pancreatic cancer: a phase II study , 2012, Cancer Chemotherapy and Pharmacology.
[20] A. Maitra,et al. Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[21] S. Temple,et al. SPARC/osteonectin, an endogenous mechanism for targeting albumin to the blood–cerebrospinal fluid interface during brain development , 2011, European Journal of Neuroscience.
[22] A. Ko. FOLFIRINOX: a small step or a great leap forward? , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[23] Qiwei Yang,et al. Secreted Protein Acidic and Rich in Cysteine Is a Matrix Scavenger Chaperone , 2011, PloS one.
[24] L. Diaz,et al. A multicenter analysis of GTX chemotherapy in patients with locally advanced and metastatic pancreatic adenocarcinoma , 2011, Cancer Chemotherapy and Pharmacology.
[25] M. Zavoral,et al. Molecular biology of pancreatic cancer. , 2011, World journal of gastroenterology.
[26] M. Borad,et al. Phase I trial erlotinib, gemcitabine, and the hedgehog inhibitor, GDC-0449. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[27] A. El-Khoueiry,et al. A phase I study of two different schedules of nab-paclitaxel (nab-P) with ascending doses of vandetanib (V) with expansion in patients (Pts) with pancreatic cancer (PC). , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[28] J. Bachet,et al. Treatment of Pancreatic Cancer: What Can We Really Predict Today? , 2011, Cancers.
[29] M. Willson,et al. CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans , 2011 .
[30] A. Jemal,et al. Global Cancer Statistics , 2011 .
[31] M. Reni,et al. A randomized phase II trial of two different 4-drug combinations in advanced pancreatic adenocarcinoma: cisplatin, capecitabine, gemcitabine plus either epirubicin or docetaxel (PEXG or PDXG regimen) , 2011, Cancer Chemotherapy and Pharmacology.
[32] D. Mavroudis,et al. Second-line chemotherapy with Capecitabine (Xeloda) and Docetaxel (Taxotere) in previously treated, unresectable adenocarcinoma of pancreas: the final results of a phase II trial , 2011, Cancer Chemotherapy and Pharmacology.
[33] J. Kleeff,et al. Tumor microenvironment and progression of pancreatic cancer. , 2010, Experimental oncology.
[34] Muhammad Wasif Saif,et al. Docetaxel second-line therapy in patients with advanced pancreatic cancer: a retrospective study. , 2010, Anticancer research.
[35] G. Hostetter,et al. Radiosensitization and Stromal Imaging Response Correlates for the HIF-1 Inhibitor PX-478 Given with or without Chemotherapy in Pancreatic Cancer , 2010, Molecular Cancer Therapeutics.
[36] S. Anant,et al. Cancer stem cells: a novel paradigm for cancer prevention and treatment. , 2010, Mini reviews in medicinal chemistry.
[37] M. Falconi,et al. Pancreatic cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. , 2010, Annals of oncology : official journal of the European Society for Medical Oncology.
[38] Tibor Schuster,et al. Preoperative/Neoadjuvant Therapy in Pancreatic Cancer: A Systematic Review and Meta-analysis of Response and Resection Percentages , 2010, PLoS medicine.
[39] Julien Reyal. Arterial flow focalization could increase tissue oxygen partial pressure, or trigger endothelial shear stress - a new concept to overcome cancer hypoxia-induced radiotherapy resistance, or stimulate liver regeneration during fulminant hepatitis. , 2010, Medical hypotheses.
[40] L. Jian-hua,et al. Phase III Randomized Comparison of Gemcitabine Versus Gemcitabine plus Capecitabine in Patients with Advanced Pancreatic Cancer , 2010 .
[41] R. Goldberg,et al. Randomized phase II study of gemcitabine administered at a fixed dose rate or in combination with cisplatin, docetaxel, or irinotecan in patients with metastatic pancreatic cancer: CALGB 89904. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[42] A. Maitra,et al. The hedgehog pathway and pancreatic cancer. , 2009, The New England journal of medicine.
[43] Rolf A. Brekken,et al. SPARC: a matricellular regulator of tumorigenesis , 2009, Journal of Cell Communication and Signaling.
[44] A. Bradshaw. The role of SPARC in extracellular matrix assembly , 2009, Journal of Cell Communication and Signaling.
[45] M. Reni,et al. Carbohydrate antigen 19‐9 change during chemotherapy for advanced pancreatic adenocarcinoma , 2009, Cancer.
[46] David Allard,et al. Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer , 2009, Science.
[47] Helmut Friess,et al. Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma. , 2009, Neoplasia.
[48] G. Feldmann,et al. A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development , 2009, Molecular Cancer Therapeutics.
[49] N. Desai,et al. Nab Technology : A Drug Delivery Platform Utilising Endothelial gp 60 Receptor-based Transport and Tumour-derived SPARC for Targeting I , 2009 .
[50] F. Rödel,et al. Stromal SPARC expression and patient survival after chemoradiation for non-resectable pancreatic adenocarcinoma , 2008, Cancer biology & therapy.
[51] G. Parmigiani,et al. Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses , 2008, Science.
[52] M. Mullendore,et al. Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer , 2008, Gut.
[53] C. Heeschen,et al. Metastatic cancer stem cells: A new target for anti-cancer therapy? , 2008, Cell cycle.
[54] R. Labianca,et al. Meta-analysis of randomized trials: evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer , 2008, BMC Cancer.
[55] D. Tuveson,et al. Dynamics of the immune reaction to pancreatic cancer from inception to invasion. , 2007, Cancer research.
[56] C. Heeschen,et al. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. , 2007, Cell stem cell.
[57] Helmut Friess,et al. Pancreatic cancer microenvironment , 2007, International journal of cancer.
[58] P. Murawa,et al. Erlotinib Plus Gemcitabine Compared With Gemcitabine Alone in Patients With Advanced Pancreatic Cancer: A Phase III Trial of the National Cancer Institute of Canada Clinical Trials Group , 2023, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[59] D. V. Von Hoff,et al. Tumor-stroma interactions in pancreatic ductal adenocarcinoma , 2007, Molecular Cancer Therapeutics.
[60] C. Iacobuzio-Donahue,et al. Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[61] M. Omary,et al. The pancreatic stellate cell: a star on the rise in pancreatic diseases. , 2007, The Journal of clinical investigation.
[62] P. Dalerba,et al. Identification of pancreatic cancer stem cells. , 2006, Cancer research.
[63] M. Desai,et al. The gemcitabine, docetaxel, and capecitabine (GTX) regimen for metastatic pancreatic cancer: a retrospective analysis , 2007, Cancer Chemotherapy and Pharmacology.
[64] H. Einsele,et al. Randomized phase III trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[65] A. Jimeno,et al. Molecular biomarkers: their increasing role in the diagnosis, characterization, and therapy guidance in pancreatic cancer , 2006, Molecular Cancer Therapeutics.
[66] Kenji Yokoi,et al. Simultaneous inhibition of EGFR, VEGFR, and platelet-derived growth factor receptor signaling combined with gemcitabine produces therapy of human pancreatic carcinoma and prolongs survival in an orthotopic nude mouse model. , 2005, Cancer research.
[67] Michael Hawkins,et al. Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[68] J. Furuse,et al. Primary tumor of pancreatic cancer as a measurable target lesion in chemotherapy trials. , 2005, Japanese journal of clinical oncology.
[69] H. Friess,et al. Osteonectin Influences Growth and Invasion of Pancreatic Cancer Cells , 2005, Annals of surgery.
[70] Ireland,et al. Guidelines for the management of patients with pancreatic cancer periampullary and ampullary carcinomas. , 2005 .
[71] M. Reni,et al. Gemcitabine versus cisplatin, epirubicin, fluorouracil, and gemcitabine in advanced pancreatic cancer: a randomised controlled multicentre phase III trial. , 2005, The Lancet. Oncology.
[72] R. Labianca,et al. Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[73] S Pancreatic,et al. Guidelines for the management of patients with pancreatic cancer periampullary and ampullary carcinomas , 2005, Gut.
[74] P. Soon-Shiong,et al. SPARC expression in breast tumors may correlate to increased tumor distribution of nanoparticle albumin-bound paclitaxel (ABI-007) vs taxol , 2005 .
[75] Robert Jaster,et al. Molecular regulation of pancreatic stellate cell function , 2004, Molecular Cancer.
[76] K. Kinzler,et al. Cancer genes and the pathways they control , 2004, Nature Medicine.
[77] R. Brekken,et al. SPARC regulates TGF‐beta1‐dependent signaling in primary glomerular mesangial cells , 2004, Journal of cellular biochemistry.
[78] C. Bucana,et al. Inhibition of platelet-derived growth factor receptor phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.
[79] T. Fujita,et al. SPARC stimulates the synthesis of OPG/OCIF, MMP-2 and DNA in human periodontal ligament cells. , 2002, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.
[80] R. Ross,et al. Inhibition of PDGF‐stimulated and matrix‐mediated proliferation of human vascular smooth muscle cells by SPARC is independent of changes in cell shape or cyclin‐dependent kinase inhibitors , 2002, Journal of cellular biochemistry.
[81] M. Ducreux,et al. A phase II study: docetaxel as first-line chemotherapy for advanced pancreatic adenocarcinoma. , 2000, European journal of cancer.
[82] E. Sage,et al. Primary mesenchymal cells isolated from SPARC-null mice exhibit altered morphology and rates of proliferation. , 1999, Molecular biology of the cell.
[83] E. Sage,et al. SPARC (BM-40, Osteonectin) Inhibits the Mitogenic Effect of Vascular Endothelial Growth Factor on Microvascular Endothelial Cells* , 1998, The Journal of Biological Chemistry.
[84] R. Timpl,et al. Crystal structure and mapping by site‐directed mutagenesis of the collagen‐binding epitope of an activated form of BM‐40/SPARC/osteonectin , 1998, The EMBO journal.
[85] D. V. Von Hoff,et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. , 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[86] E. Sage,et al. SPARC antagonizes the effect of basic fibroblast growth factor on the igration of bovine aortic endothelial cells , 1992, Journal of cellular biochemistry.
[87] E. A. Everitt,et al. SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix , 1989, The Journal of cell biology.
[88] P. Bornstein,et al. Characterization of a novel serum albumin-binding glycoprotein secreted by endothelial cells in culture. , 1984, The Journal of biological chemistry.