CYTOKINETIC AND CYTOGENETIC CHANGES IN CULTURED HUMAN LEUCOCYTES AND HELA CELLS INDUCED BY BENZENE
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Action of benzene on human leucocytes and on HeLa cells were examined from cytokinetic and cytogenetic points of view. Dose-response type analysis revealed that decreased DNA synthesis of cultured human leucocytes and of HeLa cells were re-markable in dose level of 2.2×10-3 M of benzene. As far as chromosome aberrations of cultured human leucocytes were concerned, gaps and breaks were observed in dose levels of both 2.2×10-3 M and 1.1×10-3 M of benzene.