Synthesis and Structure−Activity Relationship Investigation of Adenosine-Containing Inhibitors of Histone Methyltransferase DOT1L
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Yuan Yao | Pinhong Chen | Hong Jiang | Yongcheng Song | Yuan Yao | Hong Jiang | Pinhong Chen | Yongcheng Song | Zhen Liu | Justin L Anglin | Gang Cheng | S. Dong | Zhen Liu | Gang Cheng | Lisheng Deng | Shuo Dong | Guobin Cai | L. Deng | J. Anglin | G. Cai
[1] S. Pang,et al. Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1). , 2009, Bioorganic & medicinal chemistry letters.
[2] R. Blumenthal,et al. Many paths to methyltransfer: a chronicle of convergence. , 2003, Trends in biochemical sciences.
[3] Robert E Collins,et al. Structural and sequence motifs of protein (histone) methylation enzymes. , 2005, Annual review of biophysics and biomolecular structure.
[4] Yonghong Xiao,et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. , 2011, Cancer cell.
[5] Kevin Struhl,et al. Methylation of H3-Lysine 79 Is Mediated by a New Family of HMTases without a SET Domain , 2002, Current Biology.
[6] N. Heerema,et al. Analysis of prognostic factors of acute lymphoblastic leukemia in infants: report on CCG 1953 from the Children's Oncology Group. , 2006, Blood.
[7] Feng Liu,et al. A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. , 2011, Nature chemical biology.
[8] Scott A. Armstrong,et al. MLL translocations, histone modifications and leukaemia stem-cell development , 2007, Nature Reviews Cancer.
[9] S. Pang,et al. Pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1). , 2008, Bioorganic & medicinal chemistry letters.
[10] Robert A. Copeland,et al. Protein methyltransferases as a target class for drug discovery , 2009, Nature Reviews Drug Discovery.
[11] E. De Clercq,et al. New neplanocin analogues. 7. Synthesis and antiviral activity of 2-halo derivatives of neplanocin A. , 1996, Journal of medicinal chemistry.
[12] Yuan Yao,et al. Selective inhibitors of histone methyltransferase DOT1L: design, synthesis, and crystallographic studies. , 2011, Journal of the American Chemical Society.
[13] Yi Zhang,et al. hDOT1L Links Histone Methylation to Leukemogenesis , 2005, Cell.
[14] Eric Therrien,et al. N-Benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1). , 2009, Bioorganic & medicinal chemistry letters.
[15] S. Yajima,et al. Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes. , 2011, ACS medicinal chemistry letters.
[16] T. Kouzarides. Chromatin Modifications and Their Function , 2007, Cell.
[17] B. Blagg,et al. E. coli MEP synthase: steady-state kinetic analysis and substrate binding. , 2002, Biochemistry.
[18] Yi Zhang,et al. Structure of the Catalytic Domain of Human DOT1L, a Non-SET Domain Nucleosomal Histone Methyltransferase , 2003, Cell.
[19] Axel Imhof,et al. Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9 , 2005, Nature chemical biology.
[20] Xiaobo Xia,et al. H3K79 methylation profiles define murine and human MLL-AF4 leukemias. , 2008, Cancer cell.
[21] Peter A. Jones,et al. The Epigenomics of Cancer , 2007, Cell.
[22] K. O. Elliston,et al. Chemogenetic Analysis of Human Protein Methyltransferases , 2011, Chemical biology & drug design.
[23] S. Frye,et al. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. , 2011, Journal of medicinal chemistry.
[24] Karl Mechtler,et al. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. , 2007, Molecular cell.
[25] T. Palzkill,et al. Thermodynamic Investigation of Inhibitor Binding to 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase. , 2012, ACS medicinal chemistry letters.
[26] P. Cole,et al. Chemical probes for histone-modifying enzymes. , 2008, Nature chemical biology.
[27] Anton Simeonov,et al. Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. , 2010, Journal of medicinal chemistry.
[28] Anton Simeonov,et al. Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. , 2009, Journal of medicinal chemistry.
[29] R. Coulombe,et al. Pharmacokinetics of the antiviral agent 3-deazaneplanocin A , 1995, European Journal of Drug Metabolism and Pharmacokinetics.