Toward modeling the bone marrow niche using scaffold-based 3D culture systems.

[1]  Andreas Trumpp,et al.  Targeting leukemic stem cells by breaking their dormancy , 2010, Molecular oncology.

[2]  Jian Ling,et al.  Reconstitution of marrow-derived extracellular matrix ex vivo: a robust culture system for expanding large-scale highly functional human mesenchymal stem cells. , 2010, Stem cells and development.

[3]  S. Thrun,et al.  Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture , 2010, Science.

[4]  Ben D. MacArthur,et al.  Mesenchymal and haematopoietic stem cells form a unique bone marrow niche , 2010, Nature.

[5]  A. Trumpp,et al.  Awakening dormant haematopoietic stem cells , 2010, Nature Reviews Immunology.

[6]  Jean A. Niles,et al.  In vitro analog of human bone marrow from 3D scaffolds with biomimetic inverted colloidal crystal geometry. , 2009, Biomaterials.

[7]  D. Wendt,et al.  Computational evaluation of oxygen and shear stress distributions in 3D perfusion culture systems: macro-scale and micro-structured models. , 2008, Journal of biomechanics.

[8]  I. Weissman,et al.  Stems Cells and the Pathways to Aging and Cancer , 2008, Cell.

[9]  T. Suda,et al.  Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. , 2007, Cell stem cell.

[10]  Satoshi Tanaka,et al.  Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region , 2007, Nature Biotechnology.

[11]  H. Clevers,et al.  Identification of stem cells in small intestine and colon by marker gene Lgr5 , 2007, Nature.

[12]  S. Sharkis,et al.  A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. , 2007, Blood.

[13]  Ross Tubo,et al.  Mesenchymal stem cells within tumour stroma promote breast cancer metastasis , 2007, Nature.

[14]  Sangeeta N Bhatia,et al.  High-throughput analysis of signals regulating stem cell fate and function. , 2007, Current opinion in chemical biology.

[15]  Ivan Martin,et al.  Three‐Dimensional Perfusion Culture of Human Adipose Tissue‐Derived Endothelial and Osteoblastic Progenitors Generates Osteogenic Constructs with Intrinsic Vascularization Capacity , 2007, Stem cells.

[16]  K. Parmar,et al.  Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia , 2007, Proceedings of the National Academy of Sciences.

[17]  Krishnendu Roy,et al.  Influence of scaffold physical properties and stromal cell coculture on hematopoietic differentiation of mouse embryonic stem cells. , 2006, Biomaterials.

[18]  M. Cleary,et al.  Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. , 2006, Cancer cell.

[19]  T. Golub,et al.  Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9 , 2006, Nature.

[20]  Yang Liu,et al.  Ex vivo expansion of hematopoietic stem cells derived from umbilical cord blood in rotating wall vessel. , 2006, Journal of biotechnology.

[21]  K. Leong,et al.  Surface-immobilization of adhesion peptides on substrate for ex vivo expansion of cryopreserved umbilical cord blood CD34+ cells. , 2006, Biomaterials.

[22]  E. Brown,et al.  Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor , 2006, Nature.

[23]  A. Trumpp,et al.  Bone-marrow haematopoietic-stem-cell niches , 2006, Nature Reviews Immunology.

[24]  Ivan Martin,et al.  Three‐Dimensional Perfusion Culture of Human Bone Marrow Cells and Generation of Osteoinductive Grafts , 2005, Stem cells.

[25]  B. Williams,et al.  Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells. , 2005, Blood.

[26]  M. Nogami,et al.  Macroporous calcium phosphate glass-ceramic prepared by two-step pressing technique and using sucrose as a pore former , 2005, Journal of materials science. Materials in medicine.

[27]  E. Pettersen,et al.  Pericellular oxygen depletion during ordinary tissue culturing, measured with oxygen microsensors , 2005, Cell proliferation.

[28]  Y. Ko,et al.  Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size , 2005, The Journal of experimental medicine.

[29]  Tannishtha Reya,et al.  Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance , 2005, Nature Immunology.

[30]  G. Sauvageau,et al.  In vitro and in vivo expansion of hematopoietic stem cells , 2004, Oncogene.

[31]  Keisuke Ito,et al.  Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche , 2004, Cell.

[32]  E. Fuchs,et al.  Defining the Epithelial Stem Cell Niche in Skin , 2004, Science.

[33]  Haiyang Huang,et al.  Identification of the haematopoietic stem cell niche and control of the niche size , 2003, Nature.

[34]  D. Scadden,et al.  Osteoblastic cells regulate the haematopoietic stem cell niche , 2003, Nature.

[35]  D. Wendt,et al.  Oscillating perfusion of cell suspensions through three‐dimensional scaffolds enhances cell seeding efficiency and uniformity , 2003, Biotechnology and bioengineering.

[36]  M. Simon,et al.  Expansion of human SCID-repopulating cells under hypoxic conditions. , 2003, The Journal of clinical investigation.

[37]  K. Lau,et al.  Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways. , 2003, Bone.

[38]  W. Piacibello,et al.  Ex vivo expansion of human adult stem cells capable of primary and secondary hemopoietic reconstitution. , 2003, Experimental hematology.

[39]  Antonios G. Mikos,et al.  Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[40]  J. Rodríguez-Frade,et al.  The Chemokine Stromal Cell-Derived Factor-1α Modulates α4β7 Integrin-Mediated Lymphocyte Adhesion to Mucosal Addressin Cell Adhesion Molecule-1 and Fibronectin1 , 2002, The Journal of Immunology.

[41]  J. Wagner,et al.  Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. , 2001, The New England journal of medicine.

[42]  T. Ma,et al.  Thermal compression and characterization of three-dimensional nonwoven PET matrices as tissue engineering scaffolds. , 2001, Biomaterials.

[43]  V. Praloran,et al.  Primitive human HPCs are better maintained and expanded in vitro at 1 percent oxygen than at 20 percent , 2000, Transfusion.

[44]  Mutsumi Takagi,et al.  The construction of an in vitro three-dimensional hematopoietic microenvironment for mouse bone marrow cells employing porous carriers , 2000, Cytotechnology.

[45]  D. Bryder,et al.  Interleukin-3 supports expansion of long-term multilineage repopulating activity after multiple stem cell divisions in vitro , 2000 .

[46]  Manfred Biselli,et al.  Development of a fixed bed bioreactor for the expansion of human hematopoietic progenitor cells , 1999, Cytotechnology.

[47]  Daniel A. Lim,et al.  Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain , 1999, Cell.

[48]  P. Zandstra,et al.  Concentration-dependent internalization of a cytokine/cytokine receptor complex in human hematopoietic cells. , 1999, Biotechnology and bioengineering.

[49]  R. Hoffman,et al.  Progress in the development of systems for in vitro expansion of human hematopoietic stem cells. , 1999, Current opinion in hematology.

[50]  E. Papoutsakis,et al.  Increased agitation intensity increases CD13 receptor surface content and mRNA levels, and alters the metabolism of HL60 cells cultured in stirred tank bioreactors. , 1998, Biotechnology and bioengineering.

[51]  E. Papoutsakis,et al.  Oxygen tension alters the effects of cytokines on the megakaryocyte, erythrocyte, and granulocyte lineages. , 1998, Experimental hematology.

[52]  M. Koller,et al.  Clinical-scale human umbilical cord blood cell expansion in a novel automated perfusion culture system , 1998, Bone Marrow Transplantation.

[53]  M. Pykett,et al.  Enhanced maintenance and retroviral transduction of primitive hematopoietic progenitor cells using a novel three-dimensional culture system , 1997, Gene Therapy.

[54]  C. Verfaillie,et al.  A clinically suitable ex vivo expansion culture system for LTC-IC and CFC using stroma-conditioned medium. , 1997, Experimental hematology.

[55]  E. Papoutsakis,et al.  Variations in culture pH affect the cloning efficiency and differentiation of progenitor cells in ex vivo haemopoiesis , 1997, British journal of haematology.

[56]  J. Barker.  Early transplantation to a normal microenvironment prevents the development of Steel hematopoietic stem cell defects. , 1997, Experimental hematology.

[57]  J M Piret,et al.  Cytokine manipulation of primitive human hematopoietic cell self-renewal. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[58]  F. Hirayama,et al.  Interleukin 3 or interleukin 1 abrogates the reconstituting ability of hematopoietic stem cells. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[59]  M. Koller,et al.  Long-term culture-initiating cell expansion is dependent on frequent medium exchange combined with stromal and other accessory cell effects. , 1995, Blood.

[60]  P. Simmons,et al.  Use of hematopoietic growth factors for in vitro expansion of precursor cell populations , 1995, Current opinion in hematology.

[61]  J. Barker.  Sl/Sld hematopoietic progenitors are deficient in situ. , 1994, Experimental hematology.

[62]  Bernhard O. Palsson,et al.  Large-scale Expansion of Human Stem and Progenitor Cells From Bone Marrow Mononuclear Cells in Continuous Perfusion Cultures , 1993 .

[63]  L. To,et al.  Ex vivo expansion and maturation of peripheral blood CD34+ cells into the myeloid lineage. , 1992, Blood.

[64]  C. Eaves,et al.  Proliferation of totipotent hematopoietic stem cells in vitro with retention of long-term competitive in vivo reconstituting ability. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[65]  Connie,et al.  Expansion in vitro of retrovirally marked totipotent hematopoietic stem cells. , 1990, Blood.

[66]  H. Broxmeyer,et al.  The Effects of Oxidizing Species Derived from Molecular Oxygen on the Proliferation In Vitro of Human Granulocyte‐Macrophage Progenitor Cells a , 1989, Annals of the New York Academy of Sciences.

[67]  D. Wright,et al.  An analysis of the multilineage production of human hematopoietic progenitors in long-term bone marrow culture: evidence that reactive oxygen intermediates derived from mature phagocytic cells have a role in limiting progenitor cell self-renewal. , 1988, Blood.

[68]  H. Blau,et al.  Perturbation of single hematopoietic stem cell fates in artificial niches. , 2009, Integrative biology : quantitative biosciences from nano to macro.

[69]  K. McCloskey,et al.  Can shear stress direct stem cell fate? , 2009, Biotechnology progress.

[70]  A. Wagers,et al.  No place like home: anatomy and function of the stem cell niche , 2008, Nature Reviews Molecular Cell Biology.

[71]  D. Wendt,et al.  Uniform tissues engineered by seeding and culturing cells in 3D scaffolds under perfusion at defined oxygen tensions. , 2006, Biorheology.

[72]  C. Wandrey,et al.  Cultivation of hematopoietic stem and progenitor cells: biochemical engineering aspects. , 2002, Advances in biochemical engineering/biotechnology.

[73]  L. Nielsen,et al.  Bioreactors for hematopoietic cell culture. , 1999, Annual review of biomedical engineering.

[74]  T. Dexter,et al.  Long-term marrow culture: an overview of techniques and experience. , 1984, Kroc Foundation series.

[75]  R. Schofield.  The relationship between the spleen colony-forming cell and the haemopoietic stem cell. , 1978, Blood cells.

[76]  E. Braunwald.  Harrison's Principles of Internal Medicine , 1950 .