Decrease of the central type benzodiazepine receptor in cortical tubers in a patient with tuberous sclerosis.

An 18-year-old man with tuberous sclerosis was studied with I-123 lomazenil SPECT and the findings were compared with those of MRI. In all cortical tubers detected with MRI, 1-123 iomazenil binding 180-191 minutes after intravenous administration was decreased significantly. This result indicates that the binding potential of 1-123 lomazenil is decreased in cortical tubers.