Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth.
暂无分享,去创建一个
L. Tran | T. Graeber | Shunyou Wang | Jiaoti Huang | Hong Wu | I. Garraway | D. Mulholland | Ashkan Morim | Houjian Cai | Yunfeng Li | S. Plaisier
[1] S. Horvath,et al. Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance , 2010, Nature Medicine.
[2] James C. Liao,et al. Trimming of mammalian transcriptional networks using network component analysis , 2010, BMC Bioinformatics.
[3] Jiaoti Huang,et al. Identification of a Cell of Origin for Human Prostate Cancer , 2010, Science.
[4] R. Taschereau,et al. Rank–rank hypergeometric overlap: identification of statistically significant overlap between gene-expression signatures , 2010, Nucleic acids research.
[5] C. Sander,et al. Integrative genomic profiling of human prostate cancer. , 2010, Cancer cell.
[6] Zhaohui S. Qin,et al. An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression. , 2010, Cancer cell.
[7] A. Malek,et al. ETS Transcription Factors Control Transcription of EZH2 and Epigenetic Silencing of the Tumor Suppressor Gene Nkx3.1 in Prostate Cancer , 2010, PloS one.
[8] J. Humm,et al. Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1–2 study , 2010, The Lancet.
[9] Huiqing Yuan,et al. Suppression of the androgen receptor function by quercetin through protein–protein interactions of Sp1, c-Jun, and the androgen receptor in human prostate cancer cells , 2010, Molecular and Cellular Biochemistry.
[10] Su Qu,et al. PI3K-AKT-mTOR Pathway is Dominant over Androgen Receptor Signaling in Prostate Cancer Cells , 2010, Cellular oncology : the official journal of the International Society for Cellular Oncology.
[11] S. Memarzadeh,et al. Basal epithelial stem cells are efficient targets for prostate cancer initiation , 2010, Proceedings of the National Academy of Sciences.
[12] Liewei Wang,et al. Emerging role of FKBP51 in AKT kinase/protein kinase B signaling , 2010, Cell cycle.
[13] C. Cooper,et al. Steroid hormone receptors in prostate cancer: a hard habit to break? , 2009, Cancer cell.
[14] O. Witte,et al. Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model. , 2009, Cancer research.
[15] N. Cho,et al. Pathological effects of prostate cancer correlate with neuroendocrine differentiation and PTEN expression after bicalutamide monotherapy. , 2009, The Journal of urology.
[16] V. Baron,et al. Is EGR1 a potential target for prostate cancer therapy? , 2009, Future oncology.
[17] P. Majumder,et al. Inhibition of tumor growth progression by antiandrogens and mTOR inhibitor in a Pten-deficient mouse model of prostate cancer. , 2009, Cancer research.
[18] Krishna R. Kalari,et al. FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. , 2009, Cancer cell.
[19] G. Attard,et al. Antitumor activity with CYP17 blockade indicates that castration-resistant prostate cancer frequently remains hormone driven. , 2009, Cancer research.
[20] H. Scher,et al. Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer , 2009, Science.
[21] R. Hill,et al. PTEN, Stem Cells, and Cancer Stem Cells* , 2009, Journal of Biological Chemistry.
[22] David Handelsman,et al. Androgen sensitivity of prostate epithelium is enhanced by postnatal androgen receptor inactivation. , 2009, American journal of physiology. Endocrinology and metabolism.
[23] W. Gerald,et al. Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model. , 2008, The Journal of clinical investigation.
[24] S. Yeh,et al. Targeting the stromal androgen receptor in primary prostate tumors at earlier stages , 2008, Proceedings of the National Academy of Sciences.
[25] Jorge Yao,et al. Androgen receptor is a tumor suppressor and proliferator in prostate cancer , 2008, Proceedings of the National Academy of Sciences.
[26] H. Scher,et al. Targeting the androgen receptor pathway in prostate cancer. , 2008, Current opinion in pharmacology.
[27] P. Nelson,et al. Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. , 2008, Cancer research.
[28] S. Yeh,et al. Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor , 2007, Proceedings of the National Academy of Sciences.
[29] Shunyou Wang,et al. Murine cell lines derived from Pten null prostate cancer show the critical role of PTEN in hormone refractory prostate cancer development. , 2007, Cancer research.
[30] P. Nelson,et al. Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer. , 2007, Cancer research.
[31] David Handelsman,et al. Disruption of prostate epithelial androgen receptor impedes prostate lobe-specific growth and function. , 2007, Endocrinology.
[32] A. Newton,et al. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. , 2007, Molecular cell.
[33] Z. Modrušan,et al. Expression profiling of the mouse prostate after castration and hormone replacement: implication of H-cadherin in prostate tumorigenesis. , 2007, Differentiation; research in biological diversity.
[34] M. Shen,et al. Emergence of androgen independence at early stages of prostate cancer progression in Nkx3.1; Pten mice. , 2006, Cancer research.
[35] M. Gleave,et al. NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss. , 2006, Cancer cell.
[36] S. Abdulkadir,et al. Enhanced EGR1 activity promotes the growth of prostate cancer cells in an androgen‐depleted environment , 2006, Journal of cellular biochemistry.
[37] A. Newton,et al. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. , 2005, Molecular cell.
[38] S. Horvath,et al. Antibody-Based Profiling of the Phosphoinositide 3-Kinase Pathway in Clinical Prostate Cancer , 2004, Clinical Cancer Research.
[39] Chawnshang Chang,et al. Regulation of androgen receptor signaling by PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor through distinct mechanisms in prostate cancer cells. , 2004, Molecular endocrinology.
[40] Shunyou Wang,et al. PTENless means more. , 2004, Developmental biology.
[41] M. Griswold,et al. Androgen-Regulated Genes in the Murine Epididymis1 , 2004, Biology of reproduction.
[42] Daniel J. Freeman,et al. PTEN Regulates Mdm2 Expression through the P1 Promoter* , 2004, Journal of Biological Chemistry.
[43] T. Golub,et al. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways , 2004, Nature Medicine.
[44] P. Carmeliet,et al. A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[45] R. Tibshirani,et al. Gene expression profiling identifies clinically relevant subtypes of prostate cancer. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[46] Chawnshang Chang,et al. Suppression Versus Induction of Androgen Receptor Functions by the Phosphatidylinositol 3-Kinase/Akt Pathway in Prostate Cancer LNCaP Cells with Different Passage Numbers* , 2003, Journal of Biological Chemistry.
[47] P. Nelson,et al. Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. , 2003, Cancer cell.
[48] T. Graeber,et al. Myc-driven murine prostate cancer shares molecular features with human prostate tumors. , 2003, Cancer cell.
[49] R. Minchin,et al. Immunophilin chaperones in steroid receptor signalling. , 2003, Current topics in medicinal chemistry.
[50] Hubert Vesselle,et al. Phenotypic heterogeneity of end-stage prostate carcinoma metastatic to bone. , 2003, Human pathology.
[51] S. Hayward,et al. Role of stroma in carcinogenesis of the prostate. , 2002, Differentiation; research in biological diversity.
[52] M. Loda,et al. The EZH2 polycomb transcriptional repressor--a marker or mover of metastatic prostate cancer? , 2002, Cancer cell.
[53] S. Dhanasekaran,et al. The polycomb group protein EZH2 is involved in progression of prostate cancer , 2002, Nature.
[54] Biaoyang Lin,et al. The program of androgen-responsive genes in neoplastic prostate epithelium , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[55] C. Sawyers,et al. The phosphatidylinositol 3-Kinase–AKT pathway in human cancer , 2002, Nature Reviews Cancer.
[56] P. Roy-Burman,et al. Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation , 2001, Mechanisms of Development.
[57] P. Humphrey,et al. Impaired prostate tumorigenesis in Egr1-deficient mice , 2001, Nature Medicine.
[58] J. Manola,et al. Immediate hormonal therapy compared with observation after radical prostatectomy and pelvic lymphadenectomy in men with node-positive prostate cancer. , 1999, The New England journal of medicine.
[59] M. Gleave,et al. Androgenic Induction of Prostate-specific Antigen Gene Is Repressed by Protein-Protein Interaction between the Androgen Receptor and AP-1/c-Jun in the Human Prostate Cancer Cell Line LNCaP* , 1997, The Journal of Biological Chemistry.
[60] M. Soloway,et al. Small cell carcinoma of the bladder and prostate. , 1995, Urology.
[61] R. Matusik,et al. Prostate cancer in a transgenic mouse. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[62] G. Cunha. Role of mesenchymal‐epithelial interactions in normal and abnormal development of the mammary gland and prostate , 1994, Cancer.
[63] C. Logothetis,et al. Small cell carcinoma of the prostate part I a clinicopathologic study of 20 cases , 1987, Cancer.
[64] L. Chung,et al. Stromal-epithelial interactions--I. Induction of prostatic phenotype in urothelium of testicular feminized (Tfm/y) mice. , 1981, Journal of steroid biochemistry.
[65] Miriam Scadeng,et al. Development of a novel mouse glioma model using lentiviral vectors , 2009, Nature Medicine.
[66] Jeffrey A. Magee,et al. Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element. , 2006, Endocrinology.